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Cholesterol in GPCR Structures: Prevalence and Relevance

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Abstract

Bound cholesterol molecules are emerging as important hallmarks of GPCR structures. In this commentary, we analyze their statistical prevalence and biological relevance.

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Acknowledgements

Work in A.C.’s laboratory has been funded by Department of Biotechnology, Govt. of India, Council of Scientific and Industrial Research, Indo-French Centre for the Promotion of Advanced Research, Life Sciences Research Board (India), University of Melbourne (IRRTF grant), and Science & Engineering Research Board, Department of Science and Technology, Govt. of India. A.C. gratefully acknowledges SERB Distinguished Fellowship (SERB, DST, Govt. of India). P.S. was supported as a Senior Project Associate by a CSIR FBR grant to A.C. We thank members of the Chattopadhyay laboratory for critically reading the manuscript.

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    Parijat Sarkar & Amitabha Chattopadhyay

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  1. Parijat Sarkar
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Correspondence to Amitabha Chattopadhyay.

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Sarkar, P., Chattopadhyay, A. Cholesterol in GPCR Structures: Prevalence and Relevance. J Membrane Biol 255, 99–106 (2022). https://doi.org/10.1007/s00232-021-00197-8

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