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Mycobacterium tuberculosis Major Facilitator Superfamily Transporters

  • Topical Review
  • Published:
The Journal of Membrane Biology Aims and scope Submit manuscript

Abstract

The cell membrane or biofilm serve as permeable barrier for xenobiotics to maintain the homeostasis of cells or bacterial community. Transport systems are essential for the uptake of nutrients and substances necessary for biofilm formation, efflux of deleterious compounds, as well as communication between cells and environment. Major facilitator superfamily (MFS) represents the largest secondary transporter family and is responsible for the transport of a broad spectrum of substrates with diverse physiochemical properties by utilizing the energy stored in electrochemical gradient across the membrane. Importantly, multidrug efflux pumps belonging to the major facilitator superfamily are important contributing factors to drug resistance and biofilm formation in many clinical strains like Mycobacterium tuberculosis. This review summarized the structural properties and functions of M. tuberculosis MFS transporters, molecular mechanisms of substrates transfer, and efflux pump inhibitors for better control of biofilm-associated infections.

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Acknowledgements

This work was supported by National key R & D plan (2016YFC0502304), National Natural Science Foundation (Grant Numbers 81371851, 81071316, 81271882, 81301394, 81172806, 81471563], the Fundamental Research Funds for the Central Universities (Grant Numbers XDJK2017D101, XDJK2017D100, XDJK2017D099. Chongqing Municipal Education Science foundation (2015-JC-020).

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  1. Ping Li and Yinzhong Gu have contributed equally to this work.

Authors and Affiliations

  1. Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, Key Laboratory of Eco-environments in Three Gorges Reservoir Region, Ministry of Education, School of Life Sciences, Southwest University, Chongqing, China

    Ping Li, Yinzhong Gu, Jiang Li, Longxiang Xie, Xue Li & Jianping Xie

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  1. Ping Li
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  2. Yinzhong Gu
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  3. Jiang Li
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Correspondence to Jianping Xie.

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Li, P., Gu, Y., Li, J. et al. Mycobacterium tuberculosis Major Facilitator Superfamily Transporters. J Membrane Biol 250, 573–585 (2017). https://doi.org/10.1007/s00232-017-9982-x

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