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In vivo measurement of [11C]verapamil kinetics in human tissues

  • Pharmacokinetics and Disposition
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European Journal of Clinical Pharmacology Aims and scope Submit manuscript

Abstract

Objective: To evaluate [11C]verapamil kinetics in humans. Methods: After intravenous injection of [11C]verapamil (370 MBq, specific activity >1600 GBq/mmol), kinetics were evaluated in five cancer patients using positron emission tomography (PET). Results: One hour after injection, accumulation of [11C] in lungs, heart and tumour was 43.0%, 1.3% and 0.9% of the injected verapamil dose, respectively. Half-lives of [11C]verapamil in these tissues were 46.2 min, 73.8 min and 23.7 min, respectively. Conclusions: Intravenously administered [11C] was mainly extracted by the lungs. Transport of a [11C]verapamil bolus out of solid tumour tissue is relatively fast.

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Authors and Affiliations

  1. PET Center, Groningen University Hospital, P.O. Box 30.001, 9700 RB Groningen, The Netherlands, The Netherlands

    N.H. Hendrikse, E.J.F. Franssen & W. Vaalburg

  2. Department of Medical Oncology, Groningen University Hospital, Groningen, The Netherlands, The Netherlands

    E.G.E. de Vries & W.T.A. van der Graaf

Authors
  1. N.H. Hendrikse
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  2. E.G.E. de Vries
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  3. E.J.F. Franssen
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  4. W. Vaalburg
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  5. W.T.A. van der Graaf
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Accepted in revised form: 22 November 2000

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Hendrikse, N., de Vries, E., Franssen, E. et al. In vivo measurement of [11C]verapamil kinetics in human tissues. Eur J Clin Pharmacol 56, 827–829 (2001). https://doi.org/10.1007/s002280000253

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  • DOI: https://doi.org/10.1007/s002280000253

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