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Etidronate (EHDP) Inhibits Osteoclastic-Bone Resorption, Promotes Apoptosis and Disrupts Actin Rings in Isolate-Mature Osteoclasts

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Abstract.

Bisphosphonates, therapeutic reagents against tumoral bone diseases (Paget's disease or osteoporosis), are potent inhibitors of bone resorption. The mechanisms by which they directly act on mature osteoclasts remain unclear. Using a recently developed technique for isolation of highly purified mammalian mature osteoclasts, we demonstrated that etidronate [ethane-1-hydroxy-1,1-diphosphonate (EHDP), 1-hydroxy-1,1-ethylidenebisphosphonate], inhibited directly osteoclastic bone-resorbing activity by pit assay. In addition, EHDP also directly induced apoptosis and disrupted actin rings in osteoclasts. The data support previous data on non-purified osteoclasts and results in vivo.

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Authors and Affiliations

  1. Department of Oral Anatomy, Meikai University School of Dentistry, Sakado, Saitama 350-02, Japan, , , , , , JP

    E. Hiroi-Furuya & T. Kameda

  2. Department of Orthodontics, Tokushima University School of Dentistry, Tokushima, Tokushima 770, Japan, , , , , , JP

    K. Hiura, H. Mano, K. Miyazawa, Y. Nakamaru, M. Watanabe-Mano & N. Okuda

  3. First Department of Oral and Maxillofacial Surgery, Meikai University School of Dentistry, Sakado, Saitama 350-02, Japan, , , , , , JP

    J. Shimada, Y. Yamamoto, Y. Hakeda & M. Kumegawa

Authors
  1. E. Hiroi-Furuya
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  2. T. Kameda
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  3. K. Hiura
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  4. H. Mano
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  5. K. Miyazawa
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  6. Y. Nakamaru
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  7. M. Watanabe-Mano
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  8. N. Okuda
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  9. J. Shimada
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  10. Y. Yamamoto
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  11. Y. Hakeda
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  12. M. Kumegawa
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Received: 26 June 1997 / Accepted: 27 July 1998

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Hiroi-Furuya, E., Kameda, T., Hiura, K. et al. Etidronate (EHDP) Inhibits Osteoclastic-Bone Resorption, Promotes Apoptosis and Disrupts Actin Rings in Isolate-Mature Osteoclasts. Calcif Tissue Int 64, 219–223 (1999). https://doi.org/10.1007/s002239900606

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  • DOI: https://doi.org/10.1007/s002239900606

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