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Parathyroid Hormone-Related Protein (1–37) Induces cAMP Response in Human Osteoblast-Like Cells

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Abstract.

During recent years parathyroid hormone-related protein (PTHrP) research has been focused on the physiological functions of different fragments of the PTHrP molecule. Here we demonstrate that PTHrP (1–37) induced cyclic adenosine monophosphate (cAMP) response in primary human osteoblast-like cells, which were well characterized by the presence of alkaline phosphatase activity and osteocalcin production after stimulation with 1,25-dihydroxyvitamin D3. However, there was no cAMP response to PTHrP (58–77). Furthermore, the response to PTHrP (1–37) was dose dependent, with a significant increase at 1 nM. The presence of PTHrP (1–37)-induced cAMP response in human osteoblast-like cells implies that aminoterminal PTHrP fragments may exert important functions in the bone.

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Authors and Affiliations

  1. Department of Molecular Medicine, Endocrine and Diabetes Unit, L1:02, Karolinska Hospital and Institute, S-171 76 Stockholm, Sweden, Sweden

    J. A. Tsai, E. Bucht, U. Sjöstedt & O. Törring

  2. Department of Orthopedic Surgery, Karolinska Hospital and Institute, Stockholm, Sweden, Sweden

    A. Stark

  3. Department of Medicine, P2132, Division of Endocrinology, National University Hospital, Rigshospitalet, Copenhagen, Denmark, Denmark

    O. Törring

Authors
  1. J. A. Tsai
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  2. E. Bucht
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  3. A. Stark
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  4. U. Sjöstedt
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  5. O. Törring
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Received: 27 January 1997 / Accepted: 26 June 1997

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Tsai, J., Bucht, E., Stark, A. et al. Parathyroid Hormone-Related Protein (1–37) Induces cAMP Response in Human Osteoblast-Like Cells. Calcif Tissue Int 62, 250–254 (1998). https://doi.org/10.1007/s002239900425

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  • DOI: https://doi.org/10.1007/s002239900425

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