Abstract
Dual-energy X-ray absorptiometry (DXA) is the gold standard for diagnosing osteoporosis; it is generally recommended in men ≥ 70 and women ≥ 65 years old. Therefore, assessment of clinical risk factors for osteoporosis is very important in individuals under the recommended age for DXA. Here, we examine the diagnostic performance of machine learning-based prediction models for osteoporosis in individuals under the recommended age for DXA examination. Data of 2210 men aged 50–69 and 1099 women aged 50–64 obtained from the Korea National Health and Nutrition Examination Survey IV–V were analyzed. Extreme gradient boosting (XGBoost) was used to find relevant clinical features and applied to three machine learning models: XGBoost, logistic regression, and a multilayer perceptron. For the prediction of osteoporosis, the XGBoost model using the top 20 features extracted from XGBoost showed the most reliable performance with area under the receiver operating characteristic curve (AUROC) of 0.73 and 0.79 in men and women, respectively. We compared the diagnostic accuracy of the Shapley additive explanation values based on a risk-score model obtained from XGBoost and conventional osteoporosis risk assessment tools for prediction of osteoporosis using optimal cut-off values for each model. We observed that a cut-off risk score of ≥ 28 in men and ≥ 47 in women was optimal to classify a positive screening for osteoporosis (an AUROC of 0.86 in men and 0.91 in women). The XGBoost-based osteoporosis-prediction model outperformed conventional risk assessment tools. Therefore, machine learning-based prediction models are a more suitable option than conventional risk assessment methods for screening osteoporosis in individuals under the recommended age for DXA examination.
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This research was supported by the National Cancer Center (NCC-2010020).
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Hyun Woo Park, Hyojung Jung, Kyoung Yeon Back, Hyeon Ju Choi, Kwang Sun Ryu, Hyo Soung Cha, Eun Kyung Lee, A Ram Hong, and Yul Hwangbo declare that they have no conflicts of interest.
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The study was conducted in accordance with the Declaration of Helsinki. The KNHANES surveys were reviewed and approved by the Institutional Review Board of the Korea Center for Disease Control and Prevention (IRB Nos. 2008-04EXP-01-C, 2009-01CON-03-2C, 2010-02CON-21, and 2011-02CON06-C).
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Supplementary file1 (TIF 439 kb)
An overview of the study flow for developing osteoporosis-prediction models. XGBoost, extreme gradient boosting; MLP, multilayer perceptron.
Supplementary file3 (TIF 1284 kb)
Correlation matrix of the extracted 20 features in men (a) and women (b).
Supplementary file5 (TIF 1126 kb)
Performances in AUROC and AUPRC using XGBoost model with top-20 importance features in men (a–b) and women (c–d). AUROC, area under the receiver operating characteristics curve; AUPRC, area under the precision-recall curve.
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Park, H.W., Jung, H., Back, K.Y. et al. Application of Machine Learning to Identify Clinically Meaningful Risk Group for Osteoporosis in Individuals Under the Recommended Age for Dual-Energy X-Ray Absorptiometry. Calcif Tissue Int 109, 645–655 (2021). https://doi.org/10.1007/s00223-021-00880-x
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DOI: https://doi.org/10.1007/s00223-021-00880-x