Abstract
Human temporal bone studies have described the distribution of afferent fibers from each of the five organelles in the labyrinth. Data from vestibular tests in patients with vestibular neuritis can be abnormal in almost any pattern. We propose a unified explanation for these patterns, based on histological and neuroanatomical factors.
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References
Alhabib SF, Saliba I (2017) Video head impulse test: a review of the literature. Eur Arch Otorhinolaryngol 274:1215–1222. https://doi.org/10.1007/s00405-016-4157-4
Arbusow V, Schulz P, Strupp M, Dieterich M, von Reinhardstoettner A, Rauch E, Brandt T (1999) Distribution of herpes simplex virus type 1 in human geniculate and vestibular ganglia: implications for vestibular neuritis. Ann Neurol 46:416–419
Bárány R (1906) Über die vom ohrlabyrinth ausgelöste gegenrollung der augen bei normalhörenden. Archiv für Ohrenheilkunde 68:1–30
Bergström B (1973) Morphological Studies of the Vestibular Nerve. In: Otolaryngology. University of Uppsala, Uppsala, p 39
Colebatch JG, Halmagyi GM (1992) Vestibular evoked potentials in human neck muscles before and after unilateral vestibular deafferentation. Neurology 42:1635–1636
Curthoys IS, Vulovic V, Burgess AM et al (2014) Neural basis of new clinical vestibular tests: otolithic neural responses to sound and vibration. Clin Exp Pharmacol Physiol 41:371–380. https://doi.org/10.1111/1440-1681.12222
Fetter M, Dichgans J (1996) Vestibular neuritis spares the inferior division of the vestibular nerve. Brain 119(Pt 3):755–763
Gacek RR, Rasmussen GL (1961) Fiber analysis of the statoacoustic nerve of guinea pig, cat, and monkey. Anat Rec 139:455–463
Goebel JA, O’Mara W, Gianoli G (2001) Anatomic considerations in vestibular neuritis. Otol Neurotol 22:512–518
Halmagyi GM, Curthoys IS (1988) A clinical sign of canal paresis. Arch Neurol 45:737–739. https://doi.org/10.1001/archneur.1988.00520310043015
Halmagyi GM, Aw ST, Karlberg M, Curthoys IS, Todd MJ (2002) Inferior vestibular neuritis. Ann N Y Acad Sci 956:306–313
Hasuike K, Sekitani T, Imate Y (1995) Enhanced MRI in patients with vestibular neuronitis. Acta Otolaryngol Suppl 519:272–274
Karlberg M, Annertz M, Magnusson M (2004) Acute vestibular neuritis visualized by 3-T magnetic resonance imaging with high-dose gadolinium. Arch Otolaryngol Head Neck Surg 130:229–232. https://doi.org/10.1001/archotol.130.2.229
Kim JS, Kim HJ (2012) Inferior vestibular neuritis. J Neurol 259:1553–1560. https://doi.org/10.1007/s00415-011-6375-4
Lee WS, Suarez C, Honrubia V, Gomez J (1990) Morphological aspects of the human vestibular nerve. Laryngoscope 100:756–764. https://doi.org/10.1288/00005537-199007000-00012
Lopez I, Ishiyama G, Tang Y, Frank M, Baloh RW, Ishiyama A (2005) Estimation of the number of nerve fibers in the human vestibular endorgans using unbiased stereology and immunohistochemistry. J Neurosci Methods 145:37–46. https://doi.org/10.1016/j.jneumeth.2004.11.024
MacDougall HG, Weber KP, McGarvie LA, Halmagyi GM, Curthoys IS (2009) The video head impulse test: diagnostic accuracy in peripheral vestibulopathy. Neurology 73:1134–1141. https://doi.org/10.1212/WNL.0b013e3181bacf85
MacDougall HG, McGarvie LA, Halmagyi GM, Curthoys IS, Weber KP (2013a) Application of the video head impulse test to detect vertical semicircular canal dysfunction. Otol Neurotol 34:974–979. https://doi.org/10.1097/MAO.0b013e31828d676d
Macdougall HG, McGarvie LA, Halmagyi GM, Curthoys IS, Weber KP (2013b) The video Head Impulse Test (vHIT) detects vertical semicircular canal dysfunction. PLoS ONE 8:e61488. https://doi.org/10.1371/journal.pone.0061488
McCaslin DL, Jacobson GP, Bennett ML, Gruenwald JM, Green AP (2014) Predictive properties of the video head impulse test: measures of caloric symmetry and self-report dizziness handicap. Ear Hear 35:e185-191. https://doi.org/10.1097/AUD.0000000000000047
Monstad P, Okstad S, Mygland A (2006) Inferior vestibular neuritis: 3 cases with clinical features of acute vestibular neuritis, normal calorics but indications of saccular failure. BMC Neurol 6:45. https://doi.org/10.1186/1471-2377-6-45
Montandon P, Gacek RR, Kimura RS (1970) Crista neglecta in the cat and human. Ann Otol Rhinol Laryngol 79:105–112. https://doi.org/10.1177/000348947007900110
Moriyama H, Itoh M, Shimada K, Otsuka N (2007) Morphometric analysis of fibers of the human vestibular nerve: sex differences. Eur Arch Otorhinolaryngol 264:471–475. https://doi.org/10.1007/s00405-006-0197-5
Nagai Y, Goto N, Goto J, Kaneko Y, Suzaki H (1999) Morphometric nerve fiber analysis and aging process of the human vestibular nerve. Okajimas Folia Anat Jpn 76:95–100
Navari E, Casani AP (2020) Lesion patterns and possible implications for recovery in acute unilateral vestibulopathy. Otol Neurotol 41:e250–e255. https://doi.org/10.1097/MAO.0000000000002476
Ozdogmus O, Sezen O, Kubilay U, Saka E, Duman U, San T, Cavdar S (2004) Connections between the facial, vestibular and cochlear nerve bundles within the internal auditory canal. J Anat 205:65–75. https://doi.org/10.1111/j.0021-8782.2004.00313.x
Rasmussen AT (1940) Studies of the VIIIth cranial nerve of man. Laryngoscope 50:67–83
Redondo-Martinez J, Becares-Martinez C, Orts-Alborch M, Garcia-Callejo FJ, Perez-Carbonell T, Marco-Algarra J (2016) Relationship between video head impulse test (vHIT) and caloric test in patients with vestibular neuritis. Acta Otorrinolaringol Esp 67:156–161. https://doi.org/10.1016/j.otorri.2015.07.005
Silverstein H, Norrell H, Haberkamp T, McDaniel AB (1986) The unrecognized rotation of the vestibular and cochlear nerves from the labyrinth to the brain stem: its implications to surgery of the eighth cranial nerve. Otolaryngol Head Neck Surg 95:543–549. https://doi.org/10.1177/019459988609500504
Strupp M, Jager L, Muller-Lisse U, Arbusow V, Reiser M, Brandt T (1998) High resolution Gd-DTPA MR imaging of the inner ear in 60 patients with idiopathic vestibular neuritis: no evidence for contrast enhancement of the labyrinth or vestibular nerve. J Vestib Res 8:427–433
Tarnutzer AA, Bockisch CJ, Buffone E, Weber KP (2020) Vestibular mapping in patients with unilateral peripheral-vestibular deficits. Neurology. https://doi.org/10.1212/WNL.0000000000010812
Taylor RL, McGarvie LA, Reid N, Young AS, Halmagyi GM, Welgampola MS (2016) Vestibular neuritis affects both superior and inferior vestibular nerves. Neurology 87:1704–1712. https://doi.org/10.1212/WNL.0000000000003223
Todd NP, Rosengren SM, Aw ST, Colebatch JG (2007) Ocular vestibular evoked myogenic potentials (OVEMPs) produced by air- and bone-conducted sound. Clin Neurophysiol 118:381–390
Voit M (1907) Zur frage der verästelung des nervus acusticus bei den sängetieren. Anat Anz 31:635–640
Weber KP, MacDougall HG, Halmagyi GM, Curthoys IS (2009) Impulsive testing of semicircular-canal function using video-oculography. Ann N Y Acad Sci 1164:486–491. https://doi.org/10.1111/j.1749-6632.2008.03730.x
Yoshino M, Kin T, Ito A et al (2015a) Combined use of diffusion tensor tractography and multifused contrast-enhanced FIESTA for predicting facial and cochlear nerve positions in relation to vestibular schwannoma. J Neurosurg 123:1480–1488. https://doi.org/10.3171/2014.11.JNS14988
Yoshino M, Kin T, Ito A et al (2015b) Diffusion tensor tractography of normal facial and vestibulocochlear nerves. Int J Comput Assist Radiol Surg 10:383–392. https://doi.org/10.1007/s11548-014-1129-2
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MC conceived the general idea, collected and organized the data and drafted the manuscript. DY contributed neuroanatomical data to strengthen the argument, reviewed and edited the manuscript for content.
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Cherchi, M., Yacovino, D.A. Histology and neuroanatomy suggest a unified mechanism to explain the distribution of lesion patterns in acute vestibular neuropathy. Exp Brain Res 239, 1395–1399 (2021). https://doi.org/10.1007/s00221-021-06094-9
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DOI: https://doi.org/10.1007/s00221-021-06094-9