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Serotonin2C receptors and drug addiction: focus on cocaine

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Abstract

This review provides an overview of the role of central serotonin2C (5-HT2C) receptors in drug addiction, specifically focusing on their impact on the neurochemical and behavioral effects of cocaine, one of the most worldwide abused drug. First, we described the neurochemical and electrophysiological mechanisms underlying the interaction between 5-HT2C receptors and the mesocorticolimbic dopaminergic network, in keeping with the key role of this system in drug abuse and dependence. Thereafter, we focused on the role of 5-HT2C receptors in the effects of cocaine in various preclinical behavioral models used in drug addiction research, such as locomotor hyperactivity, locomotor sensitization, drug discrimination, and self-administration, to end with an overview of the neurochemical mechanisms underlying the interactions between 5-HT2C receptors, mesocorticolimbic dopamine system, and cocaine. On their whole, the presented data provide compelling preclinical evidence that 5-HT2C receptor agonists may have efficacy in the treatment of cocaine abuse and dependence, thereby underlying the need for additional clinical studies to ascertain whether preclinical data translate to the human.

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Acknowledgments

This work was supported by the statutory funds of Institute of Pharmacology (Kraków, Poland), the Department of Toxicology, Faculty of Pharmacy Jagiellonian University (Kraków, Poland), the Institut National de la Recherche et de la Santé (INSERM), and Bordeaux 2 University.

Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Inserm U862, Neurocentre Magendie, Physiopathology of Addiction Group, Bordeaux, France

    Céline Devroye & Umberto Spampinato

  2. University of Bordeaux, Bordeaux, France

    Céline Devroye & Umberto Spampinato

  3. Laboratory of Drug Addiction Pharmacology, Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland

    Malgorzata Filip & Edmund Przegaliński

  4. Department of Toxicology, Faculty of Pharmacy, Jagiellonian University, Kraków, Poland

    Malgorzata Filip

  5. Brains On-Line, Groningen, The Netherlands

    Andrew C. McCreary

  6. Université Victor Segalen Bordeaux 2, Inserm U862, 146 rue Léo Saignat, 33076, Bordeaux Cedex, France

    Umberto Spampinato

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  1. Céline Devroye
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  2. Malgorzata Filip
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  3. Edmund Przegaliński
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  4. Andrew C. McCreary
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  5. Umberto Spampinato
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Correspondence to Umberto Spampinato.

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Devroye, C., Filip, M., Przegaliński, E. et al. Serotonin2C receptors and drug addiction: focus on cocaine. Exp Brain Res 230, 537–545 (2013). https://doi.org/10.1007/s00221-013-3593-2

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  • DOI: https://doi.org/10.1007/s00221-013-3593-2

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