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Abnormal force patterns for multidirectional postural responses in patients with Parkinson’s disease

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Abstract

This study tests the hypothesis that the basal ganglia are involved in optimizing postural responses for changes in perturbation direction and stance width. We compared the patterns of horizontal and vertical ground reactive forces under each leg in response to eight directions of surface translation in Parkinson’s disease (PD) subjects and age-matched control subjects standing with both narrow and wide stance. Although passive reactive forces were larger, active forces were weaker and in abnormal directions for subjects with PD. Unlike the control subjects, who corrected their postural equilibrium in response to lateral and diagonal-lateral perturbations primarily with their loaded limbs, the PD subjects used both legs more symmetrically to recover equilibrium. PD subjects also did not change the magnitude or direction of reactive forces when initial stance width changed. These results support the hypothesis that the basal ganglia are important for optimizing automatic postural response patterns for changes in perturbation direction and for initial stance conditions.

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Acknowledgements

The authors acknowledge Jill Knop for figure graphics and Leta Guptill and Patricia Carlson-Kuhta for editorial assistance. This research was supported by NIH grant AG-06457 (Dr. Horak) and HSFPO SF0011/1999-B (Dr. Dimitrova).

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Authors and Affiliations

  1. Neurological Sciences Institute, Oregon Health & Science University, Portland, Oregon, USA

    Diana Dimitrova & Fay B. Horak

  2. Department of Neurology, Oregon Health & Science University, Portland, Oregon, USA

    John Nutt & Fay B. Horak

  3. Neurological Sciences Institute, Oregon Health & Science University, OHSU West Campus—Bldg. 1, 505 NW 185th Avenue, Beaverton, OR 97006-3499, USA

    Fay B. Horak

Authors
  1. Diana Dimitrova
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  2. John Nutt
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  3. Fay B. Horak
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Correspondence to Fay B. Horak.

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Dimitrova, D., Nutt, J. & Horak, F.B. Abnormal force patterns for multidirectional postural responses in patients with Parkinson’s disease. Exp Brain Res 156, 183–195 (2004). https://doi.org/10.1007/s00221-003-1770-4

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  • DOI: https://doi.org/10.1007/s00221-003-1770-4

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