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Highly crosslinking core–shell magnetic nanocomposites based catalyst and heat free polymerization for isolation of glycoprotein

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Abstract

New approaches for the engineering of well-defined, pore modality, and multi-chemical functionality nanocomposites are crucial to generate the next generation of functional materials with recoverable and easy preparation properties. Here, a catalyst and heat free polymerization reaction is exploited and fabricated zwitterionic system around magnetic nanoparticles. N-aminoethyl piperazine propane sulfonate (AEPPS) and dopamine (DA) are introduced as the zwitterionic system, which provided abundant zwitterionic groups (NH2, SO3−, N+) and strong adhesion and various oxidation state properties. And that, the zwitterionic engineering will assemble between AEPPS and DA whereby Schiff base formation or Michael type addition. Whereafter, a series of sophisticated array of microscopic, spectroscopic, and structure techniques verify the formation of highly crosslinking internal zwitterionic architectures, well-defined core–shell structure, and better porosity. The zwitterionic structure–function relationships and striking porous structure are explored in a multi-interaction adsorption assay. The adsorption capacity of the magnetic nanocomposites was 1065.8 mg/g. And that, the system exhibited with hydrophilic-hydrophobic activity towards glycoprotein and better performance to bioactive protein (Ig-G) isolation form human whole blood sample. The synergistic enhancement interaction in hydrophilic target enrichment, easy preparation, and soft substrate properties of the AEPPS-DA zwitterionic materials make them intriguing candidates for sustainable biomedical loading and chromatographic separation.

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Acknowledgements

The authors appreciate financial support from the National Natural Science Foundation of China (Grant No. 22004105), and special project of the Marine and Fishery Department of Xiamen (No. 19CZB001HJ03). The education and research project of the young and middle-aged teachers of Fujian Province (JAT 200880).

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Authors and Affiliations

  1. Institute of Analytical Technology and Smart Instruments and Colleague of Environment and Public Healthy, Xiamen Huaxia University, Xiamen, 361024, China

    Zhi-Yong Guo, Qiu-Hong Yao, Wen-Hui Zheng, Rui-wen Jiao, Chen Zhang & Li Zhang

  2. Xiamen Environmental Monitoring Engineering Technology Research Center, Xiamen Huaxia University, Xiamen, 361024, China

    Zhi-Yong Guo & Qiu-Hong Yao

  3. College of Pharmacy, Xiamen Medicine College, Xiamen, 361005, China

    Ting-Xiu Ye

  4. State Key Laboratory of Marine Environmental Science, Xiamen University, Xiamen, 361005, China

    Xi Chen

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  1. Zhi-Yong Guo
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  4. Rui-wen Jiao
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  5. Chen Zhang
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  6. Li Zhang
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Correspondence to Xi Chen.

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Published in the topical collection featuring Sustainability in (Bio-)Analytical Chemistry.

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Guo, ZY., Yao, QH., Zheng, WH. et al. Highly crosslinking core–shell magnetic nanocomposites based catalyst and heat free polymerization for isolation of glycoprotein. Anal Bioanal Chem 414, 6393–6402 (2022). https://doi.org/10.1007/s00216-022-04202-4

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  • DOI: https://doi.org/10.1007/s00216-022-04202-4

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