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Evaluation of the degradation of acetaminophen by the filamentous fungus Scedosporium dehoogii using carbon-based modified electrodes

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Abstract

The nonpathogenic filamentous fungus Scedosporium dehoogii was used for the first time to study the electrochemical biodegradation of acetaminophen (APAP). A carbon fiber microelectrode (CFME) modified by nickel tetrasulfonated phthalocyanine (p-NiTSPc) and a carbon paste electrode (CPE) modified with coffee husks (CH) were prepared to follow the kinetics of APAP biodegradation. The electrochemical response of APAP at both electrodes was studied by cyclic voltammetry and square wave voltammetry. p-NiTSPc-CFME was suitable to measure high concentrations of APAP, whereas CH–CPE gave rise to high current densities but was subject to the passivation phenomenon. p-NiTSPc–CFME was then successfully applied as a sensor to describe the kinetics of APAP biodegradation: this was found to be of first order with a kinetics constant of 0.11 day−1 (at 25 °C) and a half-life of 6.30 days. APAP biodegradation by the fungus did not lead to the formation of p-aminophenol (PAP) and hydroquinone (HQ) that are carcinogenic, mutagenic, and reprotoxic (CMR).

The kinetics of APAP biodegradation, followed by a poly-nickel tetrasulfonated phtalocyanine modified carbon fiber microelectrode

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Acknowledgments

I. K. Tonle acknowledges the support of the Alexander von Humboldt Foundation (Germany). S. F. Mbokou was supported by ARIANES program (University of Angers, France).

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Authors and Affiliations

  1. Electrochemistry and Chemistry of Materials, Department of Chemistry, University of Dschang, P.O. Box 67 Dschang, Dschang, West 237, Cameroon

    Serge Foukmeniok Mbokou, Evangéline Njanja & Ignas Tonle Kenfack

  2. L’UNAM Université, Angers University, GEPEA, UMR-CNRS 6144, 2 Bd. Lavoisier, 49045, Angers, France

    Serge Foukmeniok Mbokou & Maxime Pontié

  3. L’UNAM Université, Angers University, GEIHP, EA 3142, Institut de Biologie en Santé PBH-IRIS, CHU, 4 rue Larrey, 49933, Angers, France

    Serge Foukmeniok Mbokou, Maxime Pontié, Bienvenue Razafimandimby & Jean-Philippe Bouchara

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  1. Serge Foukmeniok Mbokou
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  2. Maxime Pontié
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  3. Bienvenue Razafimandimby
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Mbokou, S.F., Pontié, M., Razafimandimby, B. et al. Evaluation of the degradation of acetaminophen by the filamentous fungus Scedosporium dehoogii using carbon-based modified electrodes. Anal Bioanal Chem 408, 5895–5903 (2016). https://doi.org/10.1007/s00216-016-9704-8

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  • DOI: https://doi.org/10.1007/s00216-016-9704-8

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