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Defining a molecular portrait of physical fitness

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References

  1. Haskell WL, Lee IM, Pate RR, Powell KE, Blair SN, Franklin BA, Macera CA, Heath GW, Thompson PD, Bauman A (2007) Physical activity and public health—updated recommendation for adults from the American College of Sports Medicine and the American Heart Association. Circulation 116:1081–1093

    Article  Google Scholar 

  2. Ross R, Bradshaw AJ (2009) The future of obesity reduction: beyond weight loss. Nat Rev Endocrinol 5:319–326

    Article  Google Scholar 

  3. Guadalupe-Grau A, Fuentes T, Guerra B, Calbet JAL (2009) Exercise and bone mass in adults. Sports Med 39:439–468

    Article  Google Scholar 

  4. Larose J, Sigal RJ, Boule NG, Wells GA, Prud’homme D, Fortier MS, Reid RD, Tulloch H, Coyle D, Phillips P, Jennings A, Khandwala F, Kenny GP (2010) Effect of exercise training on physical fitness in type II diabetes mellitus. Med Sci Sports Exerc 42:1439–1447

    Article  Google Scholar 

  5. Persky AM, Eddington ND, Derendorf H (2003) A review of the effects of chronic exercise and physical fitness level on resting pharmacokinetics. Int J Clin Pharmacol Ther 41:504–516

    CAS  Google Scholar 

  6. Lee JT, Chaloner EJ, Hollingsworth SJ (2006) The role of cardiopulmonary fitness and its genetic influences on surgical outcomes. Br J Surg 93:147–157

    Article  CAS  Google Scholar 

  7. Shibutani K, Inchiosa MA, Sawada K, Bairamian M (2004) Accuracy of pharmacokinetic models for predicting plasma fentanyl concentrations in lean and obese surgical patients—derivation of dosing weight (“pharmacokinetic mass”). Anesthesiology 101:603–613

    Article  CAS  Google Scholar 

  8. Han PY, Duffull SB, Kirkpatrick CMJ, Green B (2007) Dosing in obesity: a simple solution to a big problem. Clin Pharmacol Ther 82:505–508

    Article  CAS  Google Scholar 

  9. Timmons JA (2008) Commentary on viewpoint: perspective on the future use of genomics in exercise prescription. J Appl Physiol 104:1250–1250

    Article  Google Scholar 

  10. Niebuhr DW, Scott CT, Powers TE, Li Y, Han W, Millikan AM, Krauss MR (2008) Assessment of recruit motivation and strength study: preaccession physical fitness assessment predicts early attrition. Mil Med 173:555–562

    Google Scholar 

  11. Kalns J, Baskin J, Reinert A, Michael D, Santos A, Daugherty S, Wright JK (2011) Predicting success in the tactical air combat party training pipeline. Mil Med 176:431–437

    Google Scholar 

  12. Chang ST, Zahn JM, Horecka J, Kunz PL, Ford JM, Fisher GA, Le QT, Chang DT, Ji H, Koong AC (2009) Identification of a biomarker panel using a multiplex proximity ligation assay improves accuracy of pancreatic cancer diagnosis. J Transl Med 7:12

    Article  Google Scholar 

  13. Sawyers CL (2008) The cancer biomarker problem. Nature 452:548–552

    Article  CAS  Google Scholar 

  14. Babuin L, Jaffe AS (2005) Troponin: the biomarker of choice for the detection of cardiac injury. Can Med Assoc J 173:1191–1202

    Article  Google Scholar 

  15. Stevens PE, O'Donoghue DJ, de Lusignan S, Van Vlymen J, Klebe B, Middleton R, Hague N, New J, Farmer CKT (2007) Chronic kidney disease management in the United Kingdom: NEOERICA project results. Kidney Int 72:92–99

    Article  CAS  Google Scholar 

  16. Wagner EH, Sandhu N, Newton KM, McCulloch DK, Ramsey SD, Grothaus LC (2001) Effect of improved glycemic control on health care costs and utilization. Jama-J Am Med Assoc 285:182–189

    Article  CAS  Google Scholar 

  17. Timmons JA (2011) Variability in training-induced skeletal muscle adaptation. J Appl Physiol 110:846–853

    Article  Google Scholar 

  18. Hagberg JM, Rankinen T, Loos RJF, Perusse L, Roth SM, Wolfarth B, Bouchard C (2011) Advances in exercise, fitness, and performance genomics in 2010. Med Sci Sports Exer 43:743–752

    Google Scholar 

  19. Petriz BA, Gomes CP, Rocha LAO, Rezende TMB, Franco OL (2012) Proteomics applied to exercise physiology: a cutting-edge technology. J Cell Physiol 227:885–898

    Article  CAS  Google Scholar 

  20. Baggish AL, Hale A, Weiner RB, Lewis GD, Systrom D, Wang F, Wang TJ, Chan SY (2011) Dynamic regulation of circulating microRNA during acute exhaustive exercise and sustained aerobic exercise training. J Physiol 589:3983–3994

    Article  CAS  Google Scholar 

  21. Schmutz S, Däpp C, Wittwer M, Vogt M, Hoppeler H, Flück M (2006) Endurance training modulates the muscular transcriptome response to acute exercise. Pflugers Arch 451:678–687

    Article  CAS  Google Scholar 

  22. Timmons JA, Jansson E, Fischer H, Gustafsson T, Greenhaff PL, Ridden J, Rachman J, Sundberg CJ (2005) Modulation of extracellular matrix genes reflects the magnitude of physiological adaptation to aerobic exercise training in humans. BMC Biol 3:10

    Article  Google Scholar 

  23. Keller P, Vollaard NBJ, Gustafsson T, Gallagher IJ, Sundberg CJ, Rankinen T, Britton SL, Bouchard C, Koch LG, Timmons JA (2011) A transcriptional map of the impact of endurance exercise training on skeletal muscle phenotype. J Appl Physiol 110:46–59

    Article  CAS  Google Scholar 

  24. Lee YH, Wong DT (2009) Saliva: an emerging biofluid for early detection of diseases. Am J Dent 22:241–248

    Google Scholar 

  25. Algar WR, Massey M, Krull UJ (2009) The application of quantum dots, gold nanoparticles and molecular switches to optical nucleic-acid diagnostics. Trac-Trends Anal Chem 28:292–306

    Article  Google Scholar 

  26. Star A, Tu E, Niemann J, Gabriel JCP, Joiner CS, Valcke C (2006) Label-free detection of DNA hybridization using carbon nanotube network field-effect transistors. Proc Natl Acad Sci USA 103:921–926

    Article  CAS  Google Scholar 

  27. Chen L, Manz A, Day PJR (2007) Total nucleic acid analysis integrated on microfluidic devices. Lab on a Chip 7:1413–1423

    Article  CAS  Google Scholar 

  28. Huggett J, Dheda K, Bustin S, Zumla A (2005) Real-time RT-PCR normalisation; strategies and considerations. Genes Immun 6:279–284

    Article  CAS  Google Scholar 

  29. Konstantou JK, Iliadi AC, Ioannou PC, Christopoulos TK, Anagnostopoulos NI, Kanavakis E, Traeger-Synodinos J (2010) Visual screening for JAK2V617F mutation by a disposable dipstick. Anal Bioanal Chem 397:1911–1916

    Article  CAS  Google Scholar 

  30. Mark D, Haeberle S, Roth G, von Stetten F, Zengerle R (2010) Microfluidic lab-on-a-chip platforms: requirements, characteristics and applications. Chem Soc Rev 39:1153–1182

    Article  CAS  Google Scholar 

  31. Burke MF, Dunbar RL, Rader DJ (2010) Could exercise metabolomics pave the way for gymnomimetics? Sci Trans Med 2:3

    Article  Google Scholar 

  32. Huang C-C, Lin W-T, Hsu F-L, Tsai P-W, Hou C-C (2010) Metabolomics investigation of exercise-modulated changes in metabolism in rat liver after exhaustive and endurance exercises. Eur J Appl Physiol 108:557–566

    Article  CAS  Google Scholar 

  33. Vina J, Carmen Gomez-Cabrera M, Borras C, Froio T, Sanchis-Gomar F, Martinez-Bello VE, Pallardo FV (2009) Mitochondrial biogenesis in exercise and in ageing. Adv Drug Deliv Rev 61:1369–1374

    Article  CAS  Google Scholar 

  34. Pichini S, Ventura R, Palmi I, di Carlo S, Bacosi A, Langohr K, Abellan R, Pascual JA, Pacifici R, Segura J, Zuccaro P (2010) Effect of physical fitness and endurance exercise on indirect biomarkers of growth hormone and insulin misuse: immunoassay-based measurement in urine samples. J Pharm Biomed Anal 53:1003–1010

    Article  CAS  Google Scholar 

  35. Chicharro JL, Lucia A, Perez M, Vaquero AF, Urena R (1998) Saliva composition and exercise. Sports Med 26:17–27

    Article  CAS  Google Scholar 

  36. Green JM, Pritchett RC, Crews TR, McLester JR, Tucker DC (2004) Sweat lactate response between males with high and low aerobic fitness. Eur J Appl Physiol 91:1–6

    Article  CAS  Google Scholar 

  37. Konig D, Vaisanen SB, Bouchard C, Halle M, Lakka TA, Baumstark MW, Alen M, Berg A, Rauramaa R (2003) Cardiorespiratory fitness modifies the association between dietary fat intake and plasma fatty acids. Eur J Clin Nutr 57:810–815

    Article  CAS  Google Scholar 

  38. Pandey A, Mann M (2000) Proteomics to study genes and genomes. Nature 405:837–846

    Article  CAS  Google Scholar 

  39. Martinez AW, Phillips ST, Whitesides GM (2008) Three-dimensional microfluidic devices fabricated in layered paper and tape. Proc Natl Acad Sci USA 105:19606–19611

    Article  CAS  Google Scholar 

  40. Hao Y, Foster R (2008) Wireless body sensor networks for health-monitoring applications. Physiol Meas 29:R27–R56

    Article  Google Scholar 

  41. Ikonomidis I, Stamatelopoulos K, Lekakis J, Vamvakou GD, Kremastinos DT (2008) Inflammatory and non-invasive vascular markers: the multimarker approach for risk stratification in coronary artery disease. Atherosclerosis 199:3–11

    Article  CAS  Google Scholar 

  42. Kraus RM, Stallings HW, Yeager RC, Gavin TP (2004) Circulating plasma VEGF response to exercise in sedentary and endurance-trained men. J Appl Physiol 96:1445–1450

    Article  CAS  Google Scholar 

  43. Pilegaard H, Saltin B, Neufer PD (2003) Exercise induces transient transcriptional activation of the PGC-1 alpha gene in human skeletal muscle. J Physiol-Lond 546:851–858

    Article  CAS  Google Scholar 

  44. Hickner RC, Kemeny G, Stallings HW, Manning SM, McIver KL (2006) Relationship between body composition and skeletal muscle eNOS. Int J Obes 30:308–312

    Article  CAS  Google Scholar 

  45. Silva TSE, Longui CA, Rocha MN, Faria CDC, Melo MR, Faria TG, de Souza JA, Rizzo LV (2010) Prolonged physical training decreases mRNA levels of glucocorticoid receptor and inflammatory genes. Horm Res Paediatr 74:6–14

    Article  Google Scholar 

  46. Maimoun L, Mariano-Goulart D, Couret I, Manetta J, Peruchon E, Micallef JP, Verdier R, Rossi M, Leroux JL (2004) Effects of physical activities that induce moderate external loading on bone metabolism in male athletes. J Sports Sci 22:875–883

    Article  CAS  Google Scholar 

  47. Adami S, Gatti D, Viapiana O, Fiore CE, Nuti R, Luisetto G, Ponte M, Rossini M, Grp BS (2008) Physical activity and bone turnover markers: a cross-sectional and a longitudinal study. Calcif Tissue Int 83:388–392

    Article  CAS  Google Scholar 

  48. Oberbach A, Tonjes A, Kloting N, Fasshauer M, Kratzsch J, Busse MW, Paschke R, Stumvoll M, Bluher M (2006) Effect of a 4 week physical training program on plasma concentrations of inflammatory markers in patients with abnormal glucose tolerance. Eur J Endocrinol 154:577–585

    Article  CAS  Google Scholar 

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Acknowledgments

This work was supported in part by grants from the National Institutes of Health, the National Institute of Environmental Health Sciences, the National Science Foundation, and the National Aeronautics and Space Administration. S.D. is grateful for the support from the Lucille P. Markey Chair in Biochemistry and Molecular Biology of the Miller School of Medicine of the University of Miami. The authors would like to acknowledge Ariadna Soria for her assistance with this manuscript.

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Authors and Affiliations

  1. Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, R. Bunn Gautier Bldg. 1011 NW 15th Street, Miami, FL, 33136, USA

    Adam Clouse, Sapna Deo & Sylvia Daunert

  2. John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Biological Research Building, 1501 NW 10th Avenue, Miami, FL, 33136, USA

    Evadnie Rampersaud & Jeff Farmer

  3. Miller School of Medicine, University of Miami, Miami, FL, 33136, USA

    Pascal J. Goldschmidt-Clermont

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  1. Adam Clouse
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Correspondence to Sylvia Daunert.

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Clouse, A., Deo, S., Rampersaud, E. et al. Defining a molecular portrait of physical fitness. Anal Bioanal Chem 405, 21–26 (2013). https://doi.org/10.1007/s00216-012-6533-2

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