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Principles of responsive lanthanide-based luminescent probes for cellular imaging

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Abstract

The advent of chemical tools for cellular imaging—from organic dyes to green fluorescent proteins—has revolutionized the fields of molecular biology and biochemistry. Lanthanide-based probes are a new player in this area, as the last decade has seen the emergence of the first responsive luminescent lanthanide probes specifically intended for imaging cellular processes. The potential of these probes is still undervalued by the scientific community. Indeed, this class of probes offers several advantages over organic dyes and fluorescent proteins. Their very long luminescence lifetimes enable quantitative spatial determination of the intracellular concentration of an analyte through time-gating measurements. Their emission bands are very narrow and do not overlap, enabling the simultaneous use of multiple lanthanide probes to quantitatively detect several analytes without cross-interference. Herein we describe the principles behind the development of this class of probes. Sensors for a desired analyte can be designed by rationally manipulating the parameters that influence the luminescence of lanthanide complexes. We will discuss sensors based on varying the number of inner-sphere water molecules, the distance separating the antenna from the lanthanide ion, the energies of excited states of the antenna, and PeT switches.

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References

  1. Parker D (2000) Coord Chem Rev 205:109–130

    Article  CAS  Google Scholar 

  2. Parker D, Dickins RS, Puschmann H, Crossland C, Howard JAK (2002) Chem Rev 102:1977–2010

    Article  CAS  Google Scholar 

  3. Parker D (2004) Chem Soc Rev 33:156–165

    Article  CAS  Google Scholar 

  4. Gunnlaugsson T, Leonard JP (2005) Chem Commun 3114–3131

  5. Prodi L (2005) New J Chem 29:20–31

    Article  CAS  Google Scholar 

  6. Cockerill AF, Davies GLO, Harden RC, Rackham DM (1973) Chem Rev 73:553–588

    Article  CAS  Google Scholar 

  7. Geraldes CFGC, Luchinat C (2003) Met Ions Biol Syst 40:513–588

    CAS  Google Scholar 

  8. Martin LJ, Hahnke MJ, Nitz M, Wohnert J, Silvaggi NR, Allen KN, Schwalbe H, Imperiali B (2007) J Am Chem Soc 129:7106–7113

    Article  CAS  Google Scholar 

  9. Silvaggi NR, Martin LJ, Schwalbe H, Imperiali B, Allen KN (2007) J Am Chem Soc 129:7114–7120

    Article  CAS  Google Scholar 

  10. Raymond KN, Pierre VC (2005) Bioconjug Chem 16:3–8

    Google Scholar 

  11. Jacques V, Desreux JF (2002) Top Curr Chem 221:123–164

    Article  CAS  Google Scholar 

  12. Welch JT, Sirish M, Lindstrom KM, Franklin SJ (2001) Inorg Chem 40:1982–1984

    Article  CAS  Google Scholar 

  13. Mody TD, Sessler JL (2001) J Porphyr Phthalocya 5:134–142

    Google Scholar 

  14. Sabbatini N, Guardigli M, Lehn JM (1993) Coord Chem Rev 123:201–228

    Article  CAS  Google Scholar 

  15. Evans WJ, Davis BL (2002) Chem Rev 102:2119–2136

    Article  CAS  Google Scholar 

  16. Edmonds DJ, Johnston D, Procter DJ (2004) Chem Rev 104:3371–3403

    Article  CAS  Google Scholar 

  17. Trawick BN, Daniher AT, Bashkin JK (1998) Chem Rev 98:939–960

    Article  CAS  Google Scholar 

  18. Perreault DM, Anslyn EV (1997) Angew Chem Int Ed 36:432–450

    Google Scholar 

  19. Franklin SJ (2001) Curr Opin Chem Biol 5:201–208

    Article  CAS  Google Scholar 

  20. Morrow JR, Buttrey LA, Shelton VM, Berback KA (1992) J Am Chem Soc 114:1903–1905

    Article  CAS  Google Scholar 

  21. Mitsuishi M, Kikuchi S, Miyashita T, Amao Y (2003) J Mater Chem 13:2875–2879

    Article  CAS  Google Scholar 

  22. Steinkamp T, Karst U (2004) Anal Bioanal Chem 380:24–30

    Article  CAS  Google Scholar 

  23. Hemmila I, Laitala V (2005) J Fluoresc 15:529–542

    Article  CAS  Google Scholar 

  24. Frullano L, Meade TJ (2007) J Biol Inorg Chem 12:939–949

    Article  CAS  Google Scholar 

  25. Tremblay MS, Halim M, Sames D (2007) J Am Chem Soc 129:7570–7577

    Article  CAS  Google Scholar 

  26. Beeby A, Botchway SW, Clarkson IM, Faulkner S, Parker AW, Parker D, Williams JAG (2000) J Photochem Photobiol B 57:83–89

    Article  CAS  Google Scholar 

  27. Lee K, Dzubeck V, Latshaw L, Schneider JP (2004) J Am Chem Soc 126:13616–13617

    Article  CAS  Google Scholar 

  28. Thibon A, Pierre VC (2009) J Am Chem Soc 131:434–435

    Article  CAS  Google Scholar 

  29. Viguier RFH, Hulme AN (2006) J Am Chem Soc 128:11370–11371

    Article  CAS  Google Scholar 

  30. Leonard JP, dos Santos CMG, Plush SE, McCabe T, Gunnlaugsson T (2007) Chem Commun 129–131

  31. Shao N, Jin JY, Wang GL, Zhang Y, Yang RH, Yuan JL (2008) Chem Commun 1127–1129

  32. Horrocks WD, Sudnick DR (1979) J Am Chem Soc 101:334–340

    Article  CAS  Google Scholar 

  33. Horrocks WD, Sudnick DR (1981) Acc Chem Res 14:384–392

    Article  CAS  Google Scholar 

  34. Beeby A, Clarkson IM, Dickins RS, Faulkner S, Parker D, Royle L, de Sousa AS, Williams JAG, Woods M (1999) J Chem Soc Perkin Trans 2:493–503

    Google Scholar 

  35. Dickins RS, Parker D, deSousa AS, Williams JAG (1996) Chem Commun 697–698

  36. Beeby A, Burton-Pye BP, Faulkner S, Motson GR, Jeffery JC, McCleverty JA, Ward MD (2002) J Chem Soc Dalton Trans 1923–1928

  37. Beeby A, Dickins RS, Faulkner S, Parker D, Williams JAG (1997) Chem Commun 1401–1402

  38. Beeby A, Faulkner S (1997) Chem Phys Lett 266:116–122

    Article  CAS  Google Scholar 

  39. Dickins RS, Aime S, Batsanov AS, Beeby A, Botta M, Bruce J, Howard JAK, Love CS, Parker D, Peacock RD, Puschmann H (2002) J Am Chem Soc 124:12697–12705

    Article  CAS  Google Scholar 

  40. Cacheris WP, Quay SC, Rocklage SM (1990) Magn Reson Imaging 8:467–481

    Article  CAS  Google Scholar 

  41. Rofsky NM, Sherry AD, Lenkinski RE (2008) Radiology 247:608–612

    Article  Google Scholar 

  42. Bruce JI, Dickins RS, Govenlock LJ, Gunnlaugsson T, Lopinski S, Lowe MP, Parker D, Peacock RD, Perry JJB, Aime S, Botta M (2000) J Am Chem Soc 122:9674–9684

    Article  CAS  Google Scholar 

  43. Dickins RS, Gunnlaugsson T, Parker D, Peacock RD (1998) Chem Commun 1643–1644

  44. Bretonniere Y, Cann MJ, Parker D, Slater R (2002) Chem Commun 1930–1931

  45. Bretonniere Y, Cann MJ, Parker D, Slater R (2004) Org Biomol Chem 2:1624–1632

    Article  CAS  Google Scholar 

  46. Yu JH, Parker D (2005) Eur J Org Chem 4249–4252

  47. dos Santos CMG, Fernandez PB, Plush SE, Leonard JP, Gunnlaugsson T (2007) Chem Commun 3389–3391

  48. Plush SE, Gunnlaugsson T (2007) Org Lett 9:1919–1922

    Article  CAS  Google Scholar 

  49. Yamada T, Shinoda S, Tsukube H (2002) Chem Commun 1218–1219

  50. Lowe MP, Parker D (2001) Inorg Chim Acta 317:163–173

    Article  CAS  Google Scholar 

  51. Pal R, Parker D (2007) Chem Commun 474–476

  52. Gunnlaugsson T, Harte AJ, Leonard JP, Nieuwenhuyzen M (2002) Chem Commun 2134–2135

  53. Harte AJ, Jensen P, Plush SE, Kruger PE, Gunnlaugsson T (2006) Inorg Chem 45:9465–9474

    Article  CAS  Google Scholar 

  54. Li C, Wong WT (2002) Chem Commun 2034–2035

  55. Li C, Wong WT (2004) Tetrahedron Lett 45:6055–6058

    Article  CAS  Google Scholar 

  56. Magennis SW, Craig J, Gardner A, Fucassi F, Cragg PJ, Robertson N, Parsons S, Pikramenou Z (2003) Polyhedron 22:745–754

    Article  CAS  Google Scholar 

  57. Faulkner S, Burton-Pye BP, Khan T, Martin LR, Wray SD, Skabara PJ (2002) Chem Commun 1668–1669

  58. Faulkner S, Carrie MC, Pope SJA, Squire J, Beeby A, Sammes PG (2004) J Chem Soc Dalton Trans 1405–1409

  59. Cable ML, Kirby JP, Sorasaenee K, Gray HB, Ponce A (2007) J Am Chem Soc 129:1474–1475

    Article  CAS  Google Scholar 

  60. Parker D, Senanayake K, Williams JAG (1997) Chem Commun 1777–1778

  61. Parker D, Senanayake PK, Williams JAG (1998) J Chem Soc Perkin Trans 2:2129–2139

    Google Scholar 

  62. Parker D, Williams JAG (1998) Chem Commun 245–246

  63. Abusaleh A, Meares CF (1984) Photochem Photobiol 39:763–769

    Google Scholar 

  64. deSilva AP, Gunaratne HQN, Rice TE (1996) Angew Chem Int Ed 35:2116–2118

    Google Scholar 

  65. Gunnlaugsson T, Leonard JP (2003) Chem Commun 2424–2425

  66. Gunnlaugsson T, Leonard JP (2005) J Chem Soc Dalton Trans 3204–3212

  67. Li C, Law GL, Wong WT (2004) Org Lett 6:4841–4844

  68. Reany O, Gunnlaugsson T, Parker D (2000) Chem Commun 473–474

  69. Reany O, Gunnlaugsson T, Parker D (2000) J Chem Soc Perkin Trans 2:1819–1831

    Google Scholar 

  70. Hanaoka K, Kikuchi K, Kojima H, Urano Y, Nagano T (2004) J Am Chem Soc 126:12470–12476

    Google Scholar 

  71. Hanaoka K, Kikuchi K, Kojima H, Urano Y, Nagano T (2003) Angew Chem Int Ed 42:2996–2999

    Google Scholar 

  72. Tan MQ, Song B, Wang GL, Yuan JL (2006) Free Rad Biol Med 40:1644–1653

    Google Scholar 

  73. Song B, Wang GL, Tan MQ, Yuan JL (2006) J Am Chem Soc 128:13442–13450

    Google Scholar 

  74. Song B, Wang GL, Tan MQ, Yuan JL (2005) New J Chem 29:1431–1438

    Google Scholar 

  75. Song B, Wang GL, Yuan JL (2005) Chem Commun 3553–3555

  76. Best MD, Anslyn EV (2003) Chem Eur J 9:51–57

    Google Scholar 

  77. Terai T, Kikuchi K, Iwasawa SY, Kawabe T, Hirata Y, Urano Y, Nagano T (2006) J Am Chem Soc 128:6938–6946

    Google Scholar 

  78. Bunzli J-CG, Piguet C (2005) Chem Soc Rev 34:1048–1077

    Google Scholar 

Download references

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  1. Department of Chemistry, University of Minnesota, 207 Pleasant Street SE, Minneapolis, MN, 55455, USA

    Aurore Thibon & Valérie C. Pierre

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  1. Aurore Thibon
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  2. Valérie C. Pierre
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Correspondence to Valérie C. Pierre.

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Thibon, A., Pierre, V.C. Principles of responsive lanthanide-based luminescent probes for cellular imaging. Anal Bioanal Chem 394, 107–120 (2009). https://doi.org/10.1007/s00216-009-2683-2

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