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l-Arginine and NOS activity, a complex relationship

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References

  • Ali-Sisto T, Tolmunen T, Viinamaki H, Manttyselka P, Valkonen-Korhonen M, Koivumaa-Honkanen H, HonlalampiK RA, Nandania J, Velagapudi V, Letho SM (2018) Global arginine bioavailability ratio is decreased in patients with major depressive disorder. J Affect Disord 229:145–151

    Article  CAS  Google Scholar 

  • Bersani F, Wolkowitz O, Lindquist D, Yehuda R, Flory J, Bierer L, Abu-AmaraD CM, Reus V, Epel E, Marmar C, Mellon S (2016) Brain global arginine bioavailability, a marker of nitric oxide synthetic capacity, is decreased in PTSD and correlated with symptom severity and markers of inflammation. Behav Immun 52:153–160

    Article  CAS  Google Scholar 

  • Chrapko W, Jurasz P, Radomski MW, Lara N, Archer SL, Le Melledo J-M (2004) Decreased platelet nitric oxide synthase activity and plasma nitric oxide metabolites in major depressive disorder. Biol Psychiatry 56:129–134

    Article  CAS  Google Scholar 

  • Chrapko W, Jurasz P, Radomski MW, Archer SL, Newman SC, Baker G, Lara N, Le Melledo J-M (2006) Alteration of decreased plasma NO metabolites and platelet NO synthase activity by paroxetine in depressed patients. Neuropsychopharmacology 31:1286–1293

    Article  CAS  Google Scholar 

  • Loeb E, El Asmar K, Trabado S, Gressier F, Colle R, Rigal A, Martin S, Verstuyft C, Feve B, Chanson P, Becquemont L, Corruble E (2020) Nitric oxide synthase activity in major depressive episodes before and after antidepressant treatment: results of a large case-control treatment study. Psychol Med, 1-10. https://doi.org/10.1017/S003329170001749.

  • Loeb E, Becquemont L, Corruble E (2021) Is the decrease in NOx due to lack of substrate or a NOS inhibition in patients with major depression. Commentary on Hess et al., 2017. Psychopharmacology 238:613–614

    Article  CAS  Google Scholar 

  • Maes M, Bonifacio K, Morelli N, Vargas H, Moreira E, Stoyanov D, Barbosa D, Carvalho A, Nunes S (2018) Generalized anxiety disorder (GAD) and comorbid major depression with GAD are characterized by enhanced nitro-oxidative stress, increased lipid peroxidation, and lowered lipid-associated antioxidant defenses. Neurotox Res 34:489–510

    Article  CAS  Google Scholar 

  • Rapaport MH (2001) Prevalence, recognition, and treatment of comorbid depression and anxiety. J Clin Psychiatr 62(suppl 24):6–10

    Google Scholar 

  • Selley ML (2004) Increased (E)-4-hydroxynonenal and asymmetric dimethylarginine concentrations and decrease nitric oxide concentrations in the plasma of patients with major depression. J Affect Disord 80:249–256

    Article  CAS  Google Scholar 

  • Van Zyl LT, Lesperance F, Frasure-Smith N, Malinin AI, Atar D, Laliberte MA, Serebruany VL (2009) Platelet and endothelial activity in comorbid major depression and coronary artery disease patients treated with citalopram: the Canadian cardiac Randomized evaluation of antidepressant and psychotherapy efficacy trial (CREATE) biomarker sub-study. J Thromb Thrombolysis 27(48-56):91

    Google Scholar 

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Authors and Affiliations

  1. University of Alberta, Edmonton, Canada

    Jean-Michel Le Melledo, Glen Baker, Gabor Gyenes, Ross Tsuyuki & Paul Jurasz

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  1. Jean-Michel Le Melledo
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  2. Glen Baker
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  3. Gabor Gyenes
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  4. Ross Tsuyuki
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  5. Paul Jurasz
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Correspondence to Jean-Michel Le Melledo.

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Le Melledo, JM., Baker, G., Gyenes, G. et al. l-Arginine and NOS activity, a complex relationship. Psychopharmacology 238, 1223–1224 (2021). https://doi.org/10.1007/s00213-021-05799-7

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