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Systemic pharmacology understanding of the key mechanism of Sedum sarmentosum Bunge in treating hepatitis

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Abstract

Sedum sarmentosum Bunge is a Traditional Chinese Medicine that is widely used in treating hepatitis, whereas the detailed mechanisms have not been fully interpreted. A systemic pharmacology method including absorption, distribution, metabolism and elimination screening, drug targeting, interaction network plotting, and enrichment analysis was applied for exploring the underlying mechanisms of Sedum sarmentosum Bunge in the treatment of hepatitis. A total of 47 ingredients were identified in Sedum sarmentosum Bunge, and 5 active ingredients (DFV, isorhamnetin, beta-sitosterol, luteolin and quercetin) were screened out with the criteria of oral bioavailability (OB) ≥ 30% and drug-likeness (DL) ≥ 0.18. Those 5 ingredients interacted with 170 targets, 163 of which were hepatitis-related. By compound-target-disease network plotting, protein-protein interaction network plotting and enrichment analysis, the pathways that the 5 ingredients engaged in during hepatitis development and progression were investigated, such as threonine-protein kinase signaling. The integrated systemic pharmacology analysis facilitates the in-depth understanding of Sedum sarmentosum Bunge in the hepatitis treatment, which also paves the way for further knowledge of the molecular mechanism of Sedum sarmentosum Bunge in treating hepatitis.

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The authors declare that the data are available.

References

  • Antunes-Ricardo M, Rodríguez-Rodríguez C, Gutiérrez-Uribe JA, Cepeda-Cañedo E, Serna-Saldívar SO (2017) Bioaccessibility, intestinal permeability and plasma stability of isorhamnetin glycosides from Opuntia ficus-indica (L.). Int J Mol Sci 18(8):1816

  • Bastard JP et al (2018) Elevated adiponectin and sTNFRII serum levels can predict progression to hepatocellular carcinoma in patients with compensated HCV1 cirrhosis. Eur Cytokine Netw 29(3):112–120

    Article  CAS  Google Scholar 

  • Chang XJ et al (2019) On-treatment monitoring of liver fibrosis with serum hepatitis B core-related antigen in chronic hepatitis B. World J Gastroenterol 25(32):4764–4778

    Article  CAS  Google Scholar 

  • Chen T et al (2007) Absorption and excretion of luteolin and apigenin in rats after oral administration of Chrysanthemum morifolium extract. J Agric Food Chem 55(2):273–277

    Article  CAS  Google Scholar 

  • Choi YH (2019) Isorhamnetin induces ROS-dependent cycle arrest at G2/M phase and apoptosis in human hepatocarcinoma Hep3B cells. Gen Physiol Biophys 38(6):473–484

    Article  Google Scholar 

  • Devaraj E, Roy A, Royapuram Veeraragavan G et al (2020) β-Sitosterol attenuates carbon tetrachloride-induced oxidative stress and chronic liver injury in rats. Naunyn Schmiedebergs Arch Pharmacol 393(6):1067–1075

  • Do A, Reau NS (2020) Chronic viral hepatitis: current management and future directions. Hepatol Commun 4(3):329–341

    Article  Google Scholar 

  • Du B et al (2020) Systems pharmacology uncovers multiple mechanisms of erxian decoction () for treatment of premature ovarian failure. Chin J Integr Med 26(2):106–113

    Article  CAS  Google Scholar 

  • Fadda LM et al (2018) Quercetin and idebenone ameliorate oxidative stress, inflammation, DNA damage, and apoptosis induced by titanium dioxide nanoparticles in rat liver. Dose Response 16(4):1559325818812188

    Article  CAS  Google Scholar 

  • Geng W et al (2020) Liquiritigenin suppresses the activation of hepatic stellate cells via targeting miR-181b/PTEN axis. Phytomedicine 66:153108

    Article  CAS  Google Scholar 

  • Gumede NM et al (2020) beta-Sitosterol mitigates the development of high-fructose diet-induced nonalcoholic fatty liver disease in growing male Sprague-Dawley rats. Can J Physiol Pharmacol 98(1):44–50

    Article  CAS  Google Scholar 

  • Han YJ, Kang B, Yang EJ, Choi MK, Song IS (2019) Simultaneous determination and pharmacokinetic characterization of glycyrrhizin, isoliquiritigenin, liquiritigenin, and liquiritin in rat plasma following oral administration of glycyrrhizae radix extract. Molecules 24(9):1816

  • Hao L et al (2020) Sedum sarmentosum Bunge extract ameliorates lipopolysaccharide- and D-galactosamine-induced acute liver injury by attenuating the hedgehog signaling pathway via regulation of miR-124 expression. BMC Complement Med Ther 20(1):88

    Article  Google Scholar 

  • Huang L et al (2018) Ameliorative effect of Sedum sarmentosum Bunge extract on Tilapia fatty liver via the PPAR and P53 signaling pathway. Sci Rep 8(1):8456

    Article  Google Scholar 

  • Huang Z et al (2019) Liquiritigenin and liquiritin alleviated monocrotaline-induced hepatic sinusoidal obstruction syndrome via inhibiting HSP60-induced inflammatory injury. Toxicology 428:152307

    Article  CAS  Google Scholar 

  • Jing C et al (2019) Network pharmacology-based identification of the key mechanism of Qinghuo Rougan Formula acting on uveitis. Biomed Pharmacother 120:109381

    Article  CAS  Google Scholar 

  • Kim D et al (2016) Simultaneous determination of beta-sitosterol, campesterol, and stigmasterol in rat plasma by using LC-APCI-MS/MS: application in a pharmacokinetic study of a titrated extract of the unsaponifiable fraction of Zea mays L. J Sep Sci 39(21):4060–4070

    Article  CAS  Google Scholar 

  • Kim MY, Park JY, Park HS (2019) Akt1-mediated phosphorylation of RBP-Jk controls Notch1 Signaling. Biochemistry (Mosc) 84(12):1537–1546

    Article  CAS  Google Scholar 

  • Liu H et al (2013) Systems approaches and polypharmacology for drug discovery from herbal medicines: an example using licorice. J Ethnopharmacol 146(3):773–793

    Article  CAS  Google Scholar 

  • Liu J et al (2016) Systems pharmacology uncovers the multiple mechanisms of Xijiao Dihuang decoction for the treatment of viral hemorrhagic fever. Evid Based Complement Alternat Med 2016:1–17

    Google Scholar 

  • Liu N et al (2019) Isorhamnetin inhibits liver fibrosis by reducing autophagy and inhibiting extracellular matrix formation via the TGF-beta1/Smad3 and TGF-beta1/p38 MAPK pathways. Mediat Inflamm 2019:6175091

    Google Scholar 

  • Liu N et al (2020a) Traditional Chinese medicine combined with chemotherapy and cetuximab or bevacizumab for metastatic colorectal cancer: a randomized, double-blind, placebo-controlled clinical trial. Front Pharmacol 11:478

    Article  CAS  Google Scholar 

  • Liu W et al (2020b) Systems pharmacology-based study of Tanreqing injection in airway mucus hypersecretion. J Ethnopharmacol 249:112425

    Article  CAS  Google Scholar 

  • Nguyen N et al (2019) Challenges in management of autoimmune hepatitis with concurrent graves thyrotoxicosis. ACG Case Rep J 6(11):e00277

    Article  Google Scholar 

  • Park CM, Song YS (2019) Luteolin and luteolin-7-O-glucoside protect against acute liver injury through regulation of inflammatory mediators and antioxidative enzymes in GalN/LPS-induced hepatitic ICR mice. Nutr Res Pract 13(6):473–479

    Article  CAS  Google Scholar 

  • Pei T et al (2016) Systematic understanding the mechanisms of vitiligo pathogenesis and its treatment by Qubaibabuqi formula. J Ethnopharmacol 190:272–287

    Article  CAS  Google Scholar 

  • Penalva R et al (2019) Casein nanoparticles in combination with 2-hydroxypropyl-beta-cyclodextrin improves the oral bioavailability of quercetin. Int J Pharm 570:118652

    Article  CAS  Google Scholar 

  • Peng Z, Aggarwal R, Zeng N et al (2020) AKT1 regulates endoplasmic reticulum stress and mediates the adaptive response of pancreatic β cells. Mol Cell Biol 40(11):e00031–20

  • Qi W et al (2020) The implementation of drug reposition for alcoholic hepatitis based on a sub-pathway integration strategy. Ann Transl Med 8(5):208

    Article  CAS  Google Scholar 

  • Remmler J et al (2018) Increased level of interleukin 6 associates with increased 90-day and 1-year mortality in patients with end-stage liver disease. Clin Gastroenterol Hepatol 16(5):730–737

    Article  CAS  Google Scholar 

  • Reyes-Gordillo K, Shah R, Arellanes-Robledo J, Cheng Y, Ibrahim J, Tuma PL (2019) Akt1 and Akt2 isoforms play distinct roles in regulating the development of inflammation and fibrosis associated with alcoholic liver disease. Cells 8(11):1337

  • Ru J et al (2014) TCMSP: a database of systems pharmacology for drug discovery from herbal medicines. J Cheminform 6:13

    Article  Google Scholar 

  • Siegel RL, Miller KD, Jemal A (2018) Cancer statistics, 2018. CA Cancer J Clin 68(1):7–30

    Article  Google Scholar 

  • Wang D et al (2012) The role of AKT1 and autophagy in the protective effect of hydrogen sulphide against hepatic ischemia/reperfusion injury in mice. Autophagy 8(6):954–962

    Article  CAS  Google Scholar 

  • Wang X, Lin H, Zhang R (2017) The clinical efficacy and adverse effects of interferon combined with matrine in chronic hepatitis B: a systematic review and meta-analysis. Phytother Res 31(6):849–857

    Article  CAS  Google Scholar 

  • Xie Y et al (2014) Phytic acid enhances the oral absorption of isorhamnetin, quercetin, and kaempferol in total flavones of Hippophae rhamnoides L. Fitoterapia 93:216–225

    Article  CAS  Google Scholar 

  • Yang K et al (2019) Induction of interleukin 6 impairs the anti-HBV efficiency of IFN-alpha in human hepatocytes through upregulation of SOCS3. J Med Virol 91(5):803–812

    Article  CAS  Google Scholar 

  • Zeng H et al (2019) Quercetin alleviates ethanol-induced liver steatosis associated with improvement of lipophagy. Food Chem Toxicol 125:21–28

    Article  CAS  Google Scholar 

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Acknowledgments

Thanks to my colleagues.

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Authors and Affiliations

  1. Department of Pharmacy, Shanghai Tenth People’s Hospital, Shanghai, 200072, China

    MingZhu Chen & Qi Sun

Authors
  1. MingZhu Chen
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  2. Qi Sun
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Contributions

CMZ and SQ conceived and designed the research, CMZ conducted the experiments, and SQ wrote the manuscript. All the authors read and approved the manuscript, and all data were generated in-house and that no paper mill was used.

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Correspondence to Qi Sun.

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Chen, M., Sun, Q. Systemic pharmacology understanding of the key mechanism of Sedum sarmentosum Bunge in treating hepatitis. Naunyn-Schmiedeberg's Arch Pharmacol 394, 421–430 (2021). https://doi.org/10.1007/s00210-020-01952-9

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  • DOI: https://doi.org/10.1007/s00210-020-01952-9

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