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Associations of dietary oxidative balance score with femur osteoporosis in postmenopausal women: data from the National Health and Nutrition Examination Survey

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Abstract

Summary

We used data from the NHANES to explore associations of DOBS with femur BMD and osteoporosis in postmenopausal women. We found that DOBS was positively associated with femur BMD and negatively associated with the risk of osteoporosis in postmenopausal women.

Purpose

The study aimed to investigate the relationship between dietary oxidative balance score (DOBS) and the risk of osteoporosis in American postmenopausal women.

Methods

A total of 3043 participants were included in this study. The linear relationship between DOBS and femur BMD was evaluated using a weighted multivariate linear regression model. The association between DOBS and the risk of osteoporosis was assessed using a weighted logistic regression model, with odds ratios (ORs) and 95% confidence intervals (CIs) calculated. Moreover, the relationship was further characterized through smooth curve fitting (SCF) and weighted generalized additive model (GAM) analysis.

Results

After adjusting for all covariates, the weighted multivariable linear regression models showed a positive correlation between DOBS and femur BMD. Moreover, the weighted logistic regression model demonstrated that compared to the first tertile of DOBS, the highest tertile of DOBS was significantly associated with a lower risk of osteoporosis, with ORs of 0.418 (95% CI, 0.334, 0.522) for individuals under the age of 70 and 0.632 (95% CI, 0.506, 0.790) for individuals aged 70 or above. Similar trends were also observed in SCF and GAM models.

Conclusion

The present study indicated that postmenopausal women with a higher DOBS have a lower risk of femur osteoporosis. This finding may highlight the potential protective role of an antioxidant-rich diet for the bones of the postmenopausal population. Moreover, DOBS may also be a valuable tool in identifying individuals with osteoporosis. Screening and early intervention for osteoporosis may be essential for postmenopausal women with low DOBS.

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Code availability

The code of this study will be made available on reasonable request.

Data Availability

The data of this study will be made available on reasonable request.

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Acknowledgements

The authors would like to express their gratitude to the NHANES database, for the data sources in this study.

Funding

This work was supported by the National Natural Science Foundation of China (82202705), the Project of the Science and Technology Department of Sichuan Province (Grant No. 2023NSFSC1738), Clinical Research Incubation project of West China Hospital of Sichuan University (2019HXFH041), and the Sino-German Center for Research Promotion (GZ1219).

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Author notes

  1. Jie Wang and Fei Xing contributed equally to this work and share the first authorship.

Authors and Affiliations

  1. Department of Orthopaedics, Orthopaedic Research Institute, West China Hospital, Sichuan University, No. 37 Guoxue Lane, Chengdu, 610041, Sichuan, China

    Jie Wang, Fei Xing, Ning Sheng & Zhou Xiang

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  1. Jie Wang
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  2. Fei Xing
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Correspondence to Zhou Xiang.

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Wang, J., Xing, F., Sheng, N. et al. Associations of dietary oxidative balance score with femur osteoporosis in postmenopausal women: data from the National Health and Nutrition Examination Survey. Osteoporos Int 34, 2087–2100 (2023). https://doi.org/10.1007/s00198-023-06896-3

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