Abstract
Summary
The percent and absolute lumbar spine and femoral neck bone mineral densities and procollagen type I N-terminal propeptide (PINP) and urinary N-telopeptide level increases noted after teriparatide 20 μg/day treatment for 24 months were similar in the older (age ≥ 80 years) and younger (age < 80 years) subgroups.
Introduction
Many individuals are living into their eighth and ninth decades, but little is known about the efficacy of osteoporosis medication for this population. We retrospectively compared usefulness of daily teriparatide therapy in osteoporosis patients ≥80 and <80 years to detect possible age-related differences.
Methods
We analyzed 628 osteoporosis patients treated with teriparatide 20 μg/day for 24 months. The primary efficacy measures were changes in lumbar spine (LS) and femoral neck (FN) bone mineral density (BMD) over 24 months. Changes in serum procollagen type I N-terminal propeptide levels and urinary N-telopeptide (uNTX) excretion were also measured. Patients were divided into age subgroups (older, ≥80 years; younger, <80 years) for BMD and bone turnover marker comparison.
Results
In the older subgroup, the percent LS BMD significantly increased by 14.6 ± 10.4 % (mean ± SD) and FN BMD significantly increased by 4.5 ± 10.7 % at 24 months. In the younger subgroup, the percent LS BMD significantly increased by 12.2 ± 8.5 % and FN BMD significantly increased by 2.9 ± 8.3 % at 24 months. In the older subgroup, the mean absolute LS BMD change was 0.111 ± 0.071 g/cm2 and FN BMD change was 0.019 ± 0.043 g/cm2. In the younger subgroup, the mean absolute LS BMD change was 0.098 ± 0.065 g/cm2 and FN BMD change was 0.016 ± 0.045 g/cm2. The percent and absolute BMD increases in LS and FN and changes in PINP and uNTX were similar between the subgroups.
Conclusions
The usefulness of daily teriparatide treatment is not age dependent.
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Acknowledgments
The authors thank Mr. Koji Fukuda, Mr. Hideki Ito, Mr. Takeshi Kato, Ms. Kana Nakanishi, Mr. Kenji Kuroda, Mr. Haruyoshi Mizuno, Mr. Yohei Takigawa, Mr. Yoshifumi Takahashi, Mr. Hiroaki Takeuchi, Homare Nakoshi, Momoko Mizutani, Koji Shibata, Nobuyuki Tanaka, and Akiko Mizutani for their diligence in preparing the clinical recordings. The authors thank Dr. Hideki Yamamoto and Dr. Takahito Saito for their cooperation to osteoporosis treatment. Special thank to Dr. Kazushi Uemura for his advice.
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Niimi, R., Kono, T., Nishihara, A. et al. Usefulness of daily teriparatide treatment in elderly patients over 80 years of age. Osteoporos Int 27, 1869–1874 (2016). https://doi.org/10.1007/s00198-015-3479-1
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DOI: https://doi.org/10.1007/s00198-015-3479-1