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Novel ultrasonic bone densitometry based on two longitudinal waves: significant correlation with pQCT measurement values and age-related changes in trabecular bone density, cortical thickness, and elastic modulus of trabecular bone in a normal Japanese population

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Abstract

Summary

A reference database for trabecular bone density, cortical thickness, and elastic modulus of trabecular bone for a novel ultrasonic bone densitometry system (LD-100) based on two longitudinal waves (fast and slow) was determined over a wide age range in a normal Japanese population.

Introduction

A novel ultrasonic bone densitometry system (LD-100 system) was applied to create a reference database for trabecular bone density (TBD), cortical thickness (CoTh), and elastic modulus of trabecular bone (EMTb) for this device over a wide age range in a normal Japanese population.

Methods

In a comparative study between LD-100 and peripheral quantitative computed tomography (pQCT) systems, 52 individuals were examined by both systems at the same radius simultaneously. To create a reference database, a total of 2,380 healthy subjects (1,179 men, 1,201 women), ages 18–99 years, were examined using the LD-100 system.

Results

Highly significant correlations between the LD-100 and pQCT systems were found in TBD (r = 0.877, p < 0.001) and CoTh (r = 0.723, p < 0.001). For the reference database, peak values of TBD, CoTh, and EMTb were observed at 30–34 years (255.09 mg/cm3), 20–24 years (5.23 mm), and 20–24 years (4.09 GPa) in men, and at 25–29 years (209.24 mg/cm3), 25–29 years (3.98 mm), and 20–24 years (3.33 GPa) in women, respectively. The TBD fell significantly (p < 0.05) beginning at 55–59 years in both sexes, with a relatively rapid decrease in women. The CoTh showed a significant decrease beginning at 40–44 years in men and 50–54 years in women. The EMTb showed a significant decrease beginning at 40–44 years in men and 55–59 years in women.

Conclusions

The LD-100 system is a useful bone densitometry device and the database of age-related changes in TBD, CoTh, and EMTb established in this study will provide fundamental data for future studies related to bone status.

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Acknowledgments

This work was supported by the Ministry of Education, Culture, Sports, Science, and Technology, Japan. We are grateful to Mrs. Takako Shirakawa and Mrs. Hiroko Iekura for their technical assistance. We also wish to express our gratitude to Ninindoshinkai Higashinada Community General Support Center and Wakinohama Koureisya Kaigoshien Center for their invaluable support.

Conflicts of interest

None.

Author information

Authors and Affiliations

  1. Department of Biosignal Pathophysiology, Kobe University Graduate School of Medicine, Kobe, Japan

    H. Sai, G. Iguchi, T. Tobimatsu, K. Takahashi & H. Baba

  2. Medical Center for Student Health, Kobe University, 1-1, Rokkodai-cho, Nada-ku, Kobe, 657-8501, Japan

    G. Iguchi, T. Tobimatsu, K. Takahashi & H. Baba

  3. Faculty of Science and Engineering, Doshisha University, Kyoto, Japan

    T. Otani

  4. OYO Electric Co., Ltd, Kyoto, Japan

    K. Horii & I. Mano

  5. Kobe-kouyukai, Social Welfare Corporation, Kobe, Japan

    I. Nagai

  6. Hyogo Health Service Association, Kobe, Japan

    H. Iio

  7. Calcium Research Institute, Katsuragi Hospital, Kishiwada, Japan

    T. Fujita

  8. Department of Orthopedic Surgery, Hyogo College of Medicine, Nishinomiya, Japan

    K. Yoh

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  1. H. Sai
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Correspondence to H. Baba.

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Sai, H., Iguchi, G., Tobimatsu, T. et al. Novel ultrasonic bone densitometry based on two longitudinal waves: significant correlation with pQCT measurement values and age-related changes in trabecular bone density, cortical thickness, and elastic modulus of trabecular bone in a normal Japanese population. Osteoporos Int 21, 1781–1790 (2010). https://doi.org/10.1007/s00198-010-1217-2

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