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Tibial geometry is associated with failure load ex vivo: a MRI, pQCT and DXA study

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Abstract

Summary

We studied the relations between bone geometry and density and the mechanical properties of human cadaveric tibiae. Bone geometry, assessed by MRI and pQCT, and bone density, assessed by DXA, were significantly associated with bone’s mechanical properties. However, cortical density assessed by pQCT was not associated with mechanical properties.

Introduction

The primary objective of this study was to determine the contribution of cross-sectional geometry (by MRI and pQCT) and density (by pQCT and DXA) to mechanical properties of the human cadaveric tibia.

Methods

We assessed 20 human cadaveric tibiae. Bone cross-sectional geometry variables (total area, cortical area, and section modulus) were measured with MRI and pQCT. Cortical density and areal BMD were measured with pQCT and DXA, respectively. The specimens were tested to failure in a four-point bending apparatus. Coefficients of determination between imaging variables of interest and mechanical properties were determined.

Results

Cross-sectional geometry measurements from MRI and pQCT were strongly correlated with bone mechanical properties (r2 range from 0.55 to 0.85). Bone cross-sectional geometry measured by MRI explained a proportion of variance in mechanical properties similar to that explained by pQCT bone cross-sectional geometry measurements and DXA measurements.

Conclusions

We found that there was a close association between geometry and mechanical properties regardless of the imaging modality (MRI or pQCT) used.

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Acknowledgements

We thank Sylvia Renneberg and Jennifer McCord for conducting the MRI measurements. We also thank Dr. David ML Cooper for his review of the manuscript. Financial support to conduct the study was provided by the Canadian Institutes of Health Research, Natural Science and Engineering Council of Canada and the Michael Smith Foundation for Health Research to whom we are grateful.

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Authors and Affiliations

  1. Department of Orthopaedics, University of British Columbia, Vancouver, Canada

    D. Liu, S. L. Manske, S. A. Kontulainen, C. Tang, P. Guy, T. R. Oxland & H. A. McKay

  2. Department of Mechanical Engineering, University of British Columbia, Vancouver, Canada

    T. R. Oxland

  3. Department of Family Practice, University of British Columbia, Vancouver, Canada

    H. A. McKay

  4. Faculty of Kinesiology, University of Calgary, Calgary, Canada

    S. L. Manske

  5. College of Kinesiology, University of Saskatchewan, Saskatoon, Canada

    S. A. Kontulainen

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  1. D. Liu
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  2. S. L. Manske
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  3. S. A. Kontulainen
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  4. C. Tang
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  5. P. Guy
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  6. T. R. Oxland
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  7. H. A. McKay
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Corresponding author

Correspondence to H. A. McKay.

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Liu, D., Manske, S.L., Kontulainen, S.A. et al. Tibial geometry is associated with failure load ex vivo: a MRI, pQCT and DXA study. Osteoporos Int 18, 991–997 (2007). https://doi.org/10.1007/s00198-007-0325-0

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  • DOI: https://doi.org/10.1007/s00198-007-0325-0

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