Skip to main content

Advertisement

Log in

Update in fertility-sparing native-tissue procedures for pelvic organ prolapse

  • Clinical Opinion
  • Published:
International Urogynecology Journal Aims and scope Submit manuscript

Abstract

Uterine-sparing prolapse surgery has been gaining back popularity with clinicians and patients. Although both prosthetic and native-tissue surgery procedures are described, the latter is progressively regaining a central role in pelvic reconstructive surgery, owing to a lack of mesh-related complications. Available native-tissue procedures have different advantages and pitfalls, as well as different evidence profiles. Most of them offer anatomical and subjective outcomes comparable with those of hysterectomy-based procedures. Moreover, native-tissue procedures in young women desiring childbearing allow to avoid synthetic material implantation, which may lead to potentially serious complications during pregnancy. As a consequence, we do think that offering a reconstructive native-tissue procedure for uterine preservation (with the exception of the Manchester procedure) is the safest option in women wishing for pregnancy. Sacrospinous ligament hysteropexy and high uterosacral ligament hysteropexy may be considered first-line options in consideration of the higher level of evidence and lack of adverse obstetrical outcomes.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Milani R, Frigerio M, Cola A, Beretta C, Spelzini F, Manodoro S. Outcomes of transvaginal high uterosacral ligaments suspension: over 500-patient single-center study. Female Pelvic Med Reconstr Surg. 2018;24(1):39–42.

    Google Scholar 

  2. Frigerio M, Manodoro S, Cola A, Palmieri S, Spelzini F, Milani R. Detrusor underactivity in pelvic organ prolapse. Int Urogynecol J. 2018;29(8):1111–6.

    Google Scholar 

  3. Palmieri S, Cola A, Milani R, Manodoro S, Frigerio M. Quality of life in women with advanced pelvic organ prolapse treated with Gellhorn pessary. Minerva Ginecol. 2018;70(4):490–2.

    Google Scholar 

  4. Ridgeway BM. Does prolapse equal hysterectomy? The role of uterine conservation in women with uterovaginal prolapse. Am J Obstet Gynecol. 2015;213(6):802–9.

    Google Scholar 

  5. Manodoro S, Reato C, Cola A, Palmieri S, Frigerio M. Prolapse mesh complication: large stone on vaginal mesh extruded in the bladder. Eur J Obstet Gynecol Reprod Biol. 2019;235:131–2.

    Google Scholar 

  6. Milani R, Cola A, Palmieri S, Manodoro S, Frigerio M. Gluteo-vaginal fistula after prolapse mesh surgery. Eur J Obstet Gynecol Reprod Biol. 2018;225:266–7.

    Google Scholar 

  7. Milani R, Frigerio M, Palmieri S, Manodoro S. Transvaginal mesh removal with native-tissue repair for mesh shrinkage and recurrent uterovaginal prolapse following vaginal mesh-augmented surgery. Int J Gynaecol Obstet. 2017;139(1):105–6.

    Google Scholar 

  8. Lo TS, Cortes EFM, Wu PY, Tan YL, Al-Kharabsheh A, Pue LB. Assessment of collagen versus non collagen coated anterior vaginal mesh in pelvic reconstructive surgery: prospective study. Eur J Obstet Gynecol Reprod Biol. 2016;198:138–44.

    CAS  Google Scholar 

  9. Spelzini F, Manodoro S, Frigerio M, Nicolini G, Maggioni D, Donzelli E, et al. Stem cell augmented mesh materials: an in vitro and in vivo study. Int Urogynecol J. 2015;26(5):675–83.

    Google Scholar 

  10. Jefferis H, Price N, Jackson S. Pregnancy following laparoscopic hysteropexy—a case series. Gynecol Surg. 2017;14(1):16. https://doi.org/10.1186/s10397-017-1017-1.

    Article  Google Scholar 

  11. Wieslander CK, Weinstein MM, Handa VL, Collins SA. Pregnancy in women with prior treatments for pelvic floor disorders. Female Pelvic Med Reconstr Surg. 2020;26(5):299–305. https://doi.org/10.1097/SPV.0000000000000822.

    Article  Google Scholar 

  12. Meriwether KV, Balk EM, Antosh DD, et al. Uterine-preserving surgeries for the repair of pelvic organ prolapse: a systematic review with meta-analysis and clinical practice guidelines. Int Urogynecol J. 2019;30(4):505–22. https://doi.org/10.1007/s00192-019-03876-2.

    Article  Google Scholar 

  13. Schulten SFM, Detollenaere RJ, Stekelenburg J, IntHout J, Kluivers KB, van Eijndhoven HWF. Sacrospinous hysteropexy versus vaginal hysterectomy with uterosacral ligament suspension in women with uterine prolapse stage 2 or higher: observational follow-up of a multicentre randomised trial. BMJ. 2019;366:l5149.

    Google Scholar 

  14. Van IJsselmuiden MN, van Oudheusden A, Veen J, et al. Hysteropexy in the treatment of uterine prolapse stage 2 or higher: laparoscopic sacrohysteropexy versus sacrospinous hysteropexy—a multicentre randomised controlled trial (LAVA trial). BMC Womens Health. 2020;14:112.

    Google Scholar 

  15. Gutman R, Maher C. Uterine-preserving POP surgery. Int Urogynecol J. 2013;24(11):1803–13.

    Google Scholar 

  16. Lin TY, Su TH, Wang YL, et al. Risk factors for failure of transvaginal sacrospinous uterine suspension in the treatment of uterovaginal prolapse. J Formos Med Assoc. 2005;104(4):249–53.

    Google Scholar 

  17. Cavkaytar S, Kokanalı MK, Tasdemir U, Doganay M, Aksakal O. Pregnancy outcomes after transvaginal sacrospinous hysteropexy. Eur J Obstet Gynecol Reprod Biol. 2017;216:204–7.

    Google Scholar 

  18. Iliev VN, Andonova IT. Uterus preserving vaginal surgery versus vaginal hysterectomy for correction of female pelvic organ prolapse. Pril (Makedon Akad Nauk Umet Odd Med Nauki). 2014;35(1):243–7.

    Google Scholar 

  19. Thys SD, Coolen A, Martens IR, et al. A comparison of long-term outcome between Manchester Fothergill and vaginal hysterectomy as treatment for uterine descent. Int Urogynecol J. 2011;22(9):1171–8. https://doi.org/10.1007/s00192-011-1422-3.

    Article  Google Scholar 

  20. Rouzi AA, Sahly NN, Shobkshi AS, Abduljabbar HS. Manchester repair. An alternative to hysterectomy. Saudi Med J. 2009;30(11):1473–5.

    Google Scholar 

  21. Ayhan A, Esin S, Guven S, Salman C, Ozyuncu O. The Manchester operation for uterine prolapse. Int J Gynaecol Obstet. 2006;92(3):228–33. https://doi.org/10.1016/j.ijgo.2005.12.002.

    Article  CAS  Google Scholar 

  22. Singh P, Liang BLW, Han HC. A retrospective observational study on the outcomes and efficacy of the Manchester procedure as a uterine-sparing surgery for uterovaginal prolapse. J Gynecol Surg. 2018. https://doi.org/10.1089/gyn.2018.0021.

    Article  Google Scholar 

  23. Rosen DM, Shukla A, Cario GM, Carlton MA, Chou D. Is hysterectomy necessary for laparoscopic pelvic floor repair? A prospective study. J Minim Invasive Gynecol. 2008;15(6):729–34. https://doi.org/10.1016/j.jmig.2008.08.010.

    Article  Google Scholar 

  24. Milani R, Frigerio M, Spelzini F, Manodoro S. Transvaginal uterosacral ligament hysteropexy: a video tutorial. Int Urogynecol J. 2017;28(5):789–91. https://doi.org/10.1007/s00192-016-3222-2.

    Article  Google Scholar 

  25. Milani R, Frigerio M, Manodoro S, Cola A, Spelzini F. Transvaginal uterosacral ligament hysteropexy: a retrospective feasibility study. Int Urogynecol J. 2017;28(1):73–6. https://doi.org/10.1007/s00192-016-3036-2.

    Article  Google Scholar 

  26. Milani R, Manodoro S, Cola A, Bellante N, Palmieri S, Frigerio M. Transvaginal uterosacral ligament hysteropexy versus hysterectomy plus uterosacral ligament suspension: a matched cohort study. Int Urogynecol J. 2019. https://doi.org/10.1007/s00192-019-04206-2.

    Article  Google Scholar 

  27. Manodoro S, Frigerio M, Milani R, Spelzini F. Tips and tricks for uterosacral ligament suspension: how to avoid ureteral injury. Int Urogynecol J. 2018;29(1):161–3. https://doi.org/10.1007/s00192-017-3497-y.

    Article  Google Scholar 

  28. Haj-Yahya R, Chill HH, Levin G, Reuveni-Salzman A, Shveiky D. Laparoscopic uterosacral ligament hysteropexy vs total vaginal hysterectomy with uterosacral ligament suspension for anterior and apical prolapse: surgical outcome and patient satisfaction. J Minim Invasive Gynecol. 2019;27(1):88–93.

    Google Scholar 

  29. Romanzi LJ, Tyagi R. Hysteropexy compared to hysterectomy for uterine prolapse surgery: does durability differ? Int Urogynecol J. 2012;23(5):625–31.

    Google Scholar 

  30. Milani R, Manodoro S, Cola A, Palmieri S, Frigerio M. Transvaginal levator myorrhaphy for posthysterectomy vaginal vault prolapse repair. Int Urogynecol J. 2018;29(6):913–5. https://doi.org/10.1007/s00192-017-3526-x.

    Article  Google Scholar 

  31. Milani R, Manodoro S, Cola A, Palmieri S, Frigerio M. Transvaginal hysteropexy to levator myorrhaphy: a novel technique for uterine preservation. Int J Gynaecol Obstet. 2020;148(1):125–6. https://doi.org/10.1002/ijgo.12989.

    Article  Google Scholar 

  32. Huffaker RK, Kuehl TJ, Muir TW, Yandell PM, Pierce LM, Shull BL. Transverse cystocele repair with uterine preservation using native tissue. Int Urogynecol J Pelvic Floor Dysfunct. 2008;19(9):1275–81. https://doi.org/10.1007/s00192-008-0629-4.

    Article  Google Scholar 

  33. Serati M, Braga A, Cantaluppi S, Caccia G, Ghezzi F, Sorice P. Vaginal cystocele repair and hysteropexy in women with anterior and central compartment prolapse: efficacy and safety after 30 months of follow-up. Int Urogynecol J. 2018;29(6):831–6. https://doi.org/10.1007/s00192-017-3498-x.

    Article  Google Scholar 

  34. Salem HT, Tawfik RM, El Saman AM, Nasr A. Anterior abdominal wall cervicopexy for treatment of stage III and stage IV uterine prolapse. Int J Gynaecol Obstet. 2010;110(2):130–2. https://doi.org/10.1016/j.ijgo.2010.03.025.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Contributions

S. Manodoro: protocol/project development, manuscript writing; A. Braga: protocol/project development, manuscript writing; M. Barba: protocol/project development, manuscript writing; G. Caccia: protocol/project development, manuscript writing; M. Serati: protocol/project development, manuscript writing; M. Frigerio: protocol/project development, manuscript writing.

Corresponding author

Correspondence to Matteo Frigerio.

Ethics declarations

Financial disclaimers/conflicts of interest

None.

Additional information

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Manodoro, S., Braga, A., Barba, M. et al. Update in fertility-sparing native-tissue procedures for pelvic organ prolapse. Int Urogynecol J 31, 2225–2231 (2020). https://doi.org/10.1007/s00192-020-04474-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00192-020-04474-3

Keywords

Navigation