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Effect of alfuzosin on female primary bladder neck obstruction

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Abstract

Our objective was to assess the effect of the selective α1-blocker alfuzosin on urodynamic parameters and quality of life in female patients with primary bladder neck obstruction (PBNO). Twenty-five women identified as having PBNO were included in the study. After the initial assessment of urodynamic parameters and bother score index, all patients were treated with alfuzosin 5 mg twice daily for 8 weeks. After this period of time, the patients were reassessed with the same methodology as pretreatment. Symptoms subjectively improved, and patients’ satisfaction significantly increased in 64% of the patients (16 out of 25). Most urodynamic parameters were also significantly improved after treatment with alfuzosin. Alfuzosin significantly improved urodynamic parameters and alleviated bother score in almost two thirds of patients with PBNO and can be an effective first-line treatment of this situation.

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Conflicts of interest

A. Athanasopoulos is or has been an investigator, lecturer, and consultant for pharmaceutical companies producing or developing drugs for lower urinary tract symptoms (Pfizer, Astellas, Ucb, Lilly, Allergan, Bard, Amgen). P. Perimenis is or has been an investigator, lecturer, and consultant for pharmaceutical companies producing or developing drugs for lower urinary tract symptoms (Pfizer, Astellas, Lilly, Amgen). K. Giannitsas is or has been a lecturer or consultant for pharmaceutical companies producing or developing drugs for lower urinary tract symptoms (Pfizer, Lilly). K. Gyftopoulos has no disclosures.

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Authors and Affiliations

  1. Department of Urology, Medical School, University of Patras, Patras, Greece

    A. Athanasopoulos, K. Giannitsas & P. Perimenis

  2. Department of Anatomy, Medical School, University of Patras, Patras, Greece

    K. Gyftopoulos

  3. Papadiamantopoulou 38 str., Patras, Greece, 26225

    A. Athanasopoulos

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  1. A. Athanasopoulos
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  2. K. Gyftopoulos
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  3. K. Giannitsas
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  4. P. Perimenis
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Correspondence to A. Athanasopoulos.

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Athanasopoulos, A., Gyftopoulos, K., Giannitsas, K. et al. Effect of alfuzosin on female primary bladder neck obstruction. Int Urogynecol J 20, 217–222 (2009). https://doi.org/10.1007/s00192-008-0749-x

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  • DOI: https://doi.org/10.1007/s00192-008-0749-x

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