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Inherited pelvic organ prolapse in the mouse: preliminary evaluation of a new murine model

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Abstract

The objective of this study was to report the initial anatomic, radiographic, and genetic evaluations of a novel form of spontaneous pelvic organ prolapse (S-POP) in mice. We observed S-POP in a colony of UPII-SV40T transgenic mice developed for studies on bladder cancer. We utilized magnetic resonance imaging and necropsy to characterize this finding. We have established a breeding colony to identify inheritance patterns and for future studies. Selective breeding isolated the S-POP phenotype from the transgene. In contrast to other animal models, the S-POP mouse does not require an obligatory antecedent event to manifest pelvic organ prolapse. Necropsy and imaging demonstrate significant displacement of the pelvic organs distal to the pelvic floor in both sexes. The appearance of the POP is similar to that seen in the human female phenotype. Preliminary breeding studies indicate an autosomal dominant inheritance pattern. This mouse may be an effective animal model for the study of POP in humans.

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Acknowledgment

RWW and SDK were supported by a grant from the National Institutes of Health (DK075036-01A2).

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, University of Rochester Medical Center, 601 Elmwood Avenue, P.O. Box 668, Rochester, NY, 14642, USA

    Anna R. McNanley, Michael K. Flynn & Ronald W. Wood

  2. Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA

    Aimee M. Johnson & Jay E. Reeder

  3. Department of Urology, University of Rochester Medical Center, Rochester, NY, USA

    Michael K. Flynn, Ronald W. Wood & Jay E. Reeder

  4. Department of Neurobiology and Anatomy, University of Rochester Medical Center, Rochester, NY, USA

    Ronald W. Wood

  5. Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, NY, USA

    Scott D. Kennedy

  6. Department of Imaging Sciences, University of Rochester Medical Center, Rochester, NY, USA

    Jay E. Reeder

Authors
  1. Anna R. McNanley
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  2. Aimee M. Johnson
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  3. Michael K. Flynn
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  4. Ronald W. Wood
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  5. Scott D. Kennedy
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  6. Jay E. Reeder
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Correspondence to Anna R. McNanley.

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McNanley, A.R., Johnson, A.M., Flynn, M.K. et al. Inherited pelvic organ prolapse in the mouse: preliminary evaluation of a new murine model. Int Urogynecol J 20, 19–25 (2009). https://doi.org/10.1007/s00192-008-0723-7

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  • DOI: https://doi.org/10.1007/s00192-008-0723-7

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