Skip to main content

Advertisement

SpringerLink
Log in

1-year follow-up of autologous muscle-derived stem cell injection pilot study to treat stress urinary incontinence

  • Case Report
  • Published:
International Urogynecology Journal Aims and scope Submit manuscript

Abstract

We hereby report a 1-year follow-up on eight women in the first North America trial in which stress urinary incontinence (SUI) was treated with muscle-derived stem cell injections. Mean and median follow-up in this group was 16.5 and 17 months (range 3–24 months). Improvement in SUI was seen in five of eight women, with one achieving total continence. Onset of improvement was between 3 and 8 months after injection. Cure or improvement continued at a median of 10 months. No serious adverse events were reported.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Norton P, Brubaker L (2006) Urinary incontinence in women. Lancet 367:57–67

    Article  PubMed  Google Scholar 

  2. Kiilholma P, Chancellor MB, Makinen J, Hirsch IH, Klemi PJ (1993) Complications of Teflon injections for stress urinary incontinence. Neurourol Urodyn 12:131–137

    Article  PubMed  CAS  Google Scholar 

  3. Huard J, Yokoyama T, Pruchnic R, Qu Z, Li Y, Lee JY, Somogyi GT, de Groat WT, Chancellor MB (2002) Muscle-derived cell-mediated ex vivo gene therapy for urological dysfunction. Gene Ther 9:1617–1626

    Article  PubMed  CAS  Google Scholar 

  4. Rodriguez LV, Alfonso Z, Zhang R, Leung J, Wu B, Ignarro LJ (2006) Clonogenic multipotent stem cells in human adipose tissue differentiate into functional smooth muscle cells. PNAS 103:12167–12172

    Article  PubMed  CAS  Google Scholar 

  5. Strasser H, Marksteiner R, Margreiter E (2006) Transurethral ultrasound guided stem cell therapy of urinary incontinence. J Urol 175:291–292

    Article  Google Scholar 

  6. Oshima H, Payne TR, Urish KL, Sakai T, Ling Y, Gharaibeh B, Tubita K, Keller BB, Cummins JH, Huard J (2005) Differential myocardial infarct repair with muscle stem cells compared to myoblasts. Mol Ther 12:1130–1141

    Article  PubMed  CAS  Google Scholar 

  7. Lee JY, Qu-Petersen Z, Cao B, Kimura S, Jankowski R, Cummins J, Usas A, Gates G, Robbins P, Wernig A, Huard J (2000) Clonal isolation of muscle-derived cells capable of enhancing muscle regeneration and bone healing. J Cell Biol 150:1085–1100

    Article  PubMed  CAS  Google Scholar 

  8. Qu-Petersen Z, Deasy B, Jankowski R, Ikezawa M, Cummins J, Pruchnic R, Mytinger J, Cao B, Gates C, Wernig A, Huard J (2002) Identification of a novel population of muscle stem cells in mice: potential for muscle regeneration. J Cell Biol 157:851–864

    Article  PubMed  CAS  Google Scholar 

  9. Kwon D, Kim Y, Pruchnic R, Jankowski R, Isiene I, de Miguel F, Huard J, Chancellor MB (2006) Periurethral cellular injection: comparison of muscle-derived progenitor cells and fibroblasts with regard to efficacy and tissue contractility in an animal model of stress urinary incontinence. Urology 68:449–454

    Article  PubMed  Google Scholar 

Download references

Conflicts of interest

L.K. Carr, D. Steele, S. Steele and J. Erickson have received research grant support from Cook.

J Huard, M.B. Chancellor are consultant to Cook and have received research grants from Cook.

D. Wagner, R. Pruchnic and R. Jankowski are employees of Cook.

Author information

Authors and Affiliations

  1. Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, ON, M4N 3M5, Canada

    L. K. Carr, D. Steele & S. Steele

  2. Cook Myosite, 105 Delta Drive, Pittsburgh, PA, 19238, USA

    D. Wagner, R. Pruchnic & R. Jankowski

  3. University of Pittsburgh, 3471 Fifth Avenue, Pittsburgh, PA, USA

    J. Erickson, J. Huard & M. B. Chancellor

  4. University of Pittsburgh School of Medicine, 700 LS Kaufmann Building, 3471 Fifth Avenue, Pittsburgh, PA, 15213, USA

    M. B. Chancellor

Authors
  1. L. K. Carr
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. D. Steele
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S. Steele
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. D. Wagner
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. R. Pruchnic
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. R. Jankowski
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. J. Erickson
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. J. Huard
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. M. B. Chancellor
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to M. B. Chancellor.

Additional information

Funding: Cook MyoSite, Inc.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Carr, L.K., Steele, D., Steele, S. et al. 1-year follow-up of autologous muscle-derived stem cell injection pilot study to treat stress urinary incontinence. Int Urogynecol J 19, 881–883 (2008). https://doi.org/10.1007/s00192-007-0553-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00192-007-0553-z

Keywords

Search

Navigation