Skip to main content
Log in

Less is more: catecholamine-sparing strategies in septic shock

  • Less is more in Intensive Care
  • Published:
Intensive Care Medicine Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Rhodes A et al (2017) Surviving sepsis campaign:international guidelines for management of sepsis and septic shock: 2016. Intensive Care Med 43:304–377

    Article  Google Scholar 

  2. De Backer D, Aldecoa C, Njimi H, Vincent JL (2012) Dopamine versus norepinephrine in the treatment of septic shock: a meta-analysis. Crit Care Med 40:725–730

    Article  Google Scholar 

  3. Myburgh JA, Higgins A, Jovanovska A et al (2008) A comparison of epinephrine and norepinephrine in critically ill patients. Intensive Care Med 34(12):2226–2234

    Article  Google Scholar 

  4. Russell JA, Walley KR, Singer J et al (2008) Vasopressin versus nor- epinephrine infusion in patients with septic shock. N Engl J Med 358(9):877–887

    Article  CAS  Google Scholar 

  5. Venkatesh B, Finfer S, Cohen J et al (2018) Adjunctive glucocorticoid therapy in patients with septic shock. N Engl J Med 378:797–808

    Article  CAS  Google Scholar 

  6. Annane D, Renault A, Brun-Buisson C et al (2018) Hydrocortisone plus fludrocortisone for adults with septic shock. N Engl J Med 378:809–818

    Article  CAS  Google Scholar 

  7. Maheshwari K, Nathanson BH, Munson SH et al (2018) The relationship between ICU hypotension and in-hospital mortality and morbidity in septic patients. Intensive Care Med 44:857–867

    Article  Google Scholar 

  8. Asfar P, Meziani F, Hamel JF et al (2014) High versus low blood-pressure target in patients with septic shock. N Engl J Med 370(17):1583–1593

    Article  CAS  Google Scholar 

  9. Maitland K, Kiguli S, Opoka RO et al (2011) Mortality after fluid bolus in African children with severe infection. N Engl J Med 364(26):2483–2495

    Article  CAS  Google Scholar 

  10. De Oliveira FS, Freitas FG, Ferreira EM et al (2015) Positive fluid balance as a prognostic factor for mortality and acute kidney injury in severe sepsis and septic shock. J Crit Care 30(1):97–101

    Article  Google Scholar 

  11. Gordon AC, Mason AJ, Thirunavukkarasu N et al (2016) Effect of early vasopressin vs norepinephrine on kidney failure in patients with septic shock: the VANISH randomized clinical trial. JAMA 316(5):509–518

    Article  CAS  Google Scholar 

  12. Levy B, Fritz C, Tahon E et al (2018) Vasoplegia treatments: the past, the present, and the future. Crit Care 22:52

    Article  Google Scholar 

  13. Belletti A, Musu M, Silvetti S et al (2015) Non-adrenergic vasopressors in patients with or at risk for vasodilatory shock. A systematic review and meta-analysis of randomized trials. PLoS One 10(11):e0142605

    Article  Google Scholar 

  14. Khanna A, English SW, Wang XS et al (2017) Angiotensin II for the treatment of vasodilatory shock. N Engl J Med 377(5):419–430

    Article  CAS  Google Scholar 

  15. Cohen J, Venkatesh B (2019) Adjunctive corticosteroid treatment in septic shock. Anesthesiology. https://doi.org/10.1097/aln.0000000000002604

    Article  PubMed  Google Scholar 

  16. Annane D, Cariou A, Maxime V et al (2010) Corticosteroid treatment and intensive insulin therapy for septic shock in adults: a randomized controlled trial. JAMA 303:341–348

    Article  Google Scholar 

  17. Tumlin JA, Murugan R, Deane AM et al (2018) Outcomes in patients with vasodilatory shock and renal replacement therapy treated with intravenous angiotensin II. Crit Care Med 46(6):949–957

    Article  CAS  Google Scholar 

  18. Putzu A, Schorer R, Lopez-Delgado JC, Cassina T, Landoni G (2019) Blood purification and mortality in sepsis and septic shock: a systematic review and meta-analysis of randomized trials. Anesthesiology. https://doi.org/10.1097/aln.0000000000002820

    Article  PubMed  Google Scholar 

  19. Permpikul C, Tongyoo S, Viarasilpa T, Trainarongsakul T, Chakorn T, Udompanturak S (2019) Early use of norepinephrine in septic shock resuscitation (CENSER): a randomized trial. Am J Respir Crit Care Med 199:1097–1105

    Article  CAS  Google Scholar 

  20. Vail E, Gershengorn HB, Hua M, Walkey AJ, Rubenfeld G, Wunsch H (2017) Association between US norepinephrine shortage and mortality among patients with septic shock. JAMA 317(14):1433–1442

    Article  Google Scholar 

Download references

Acknowledgements

Prof. Venkatesh is supported by an NHMRC-Medical Research Future Fund Practitioner Fellowship. This work was also supported by an NHMRC grant APP1161182.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Balasubramanian Venkatesh.

Ethics declarations

Conflicts of interest

The authors do not have any financial conflict of interest in association with this manuscript.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Venkatesh, B., Khanna, A.K. & Cohen, J. Less is more: catecholamine-sparing strategies in septic shock. Intensive Care Med 45, 1810–1812 (2019). https://doi.org/10.1007/s00134-019-05770-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00134-019-05770-3

Navigation