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Biomarkers of ARDS: what’s new?

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References

  1. Janz DR, Ware LB (2013) Biomarkers of ALI/ARDS: pathogenesis, discovery, and relevance to clinical trials. Semin Respir Crit Care Med 34(4):537–548

    Article  PubMed  Google Scholar 

  2. Terpstra ML, Aman J, van Nieuw Amerongen GP, Groeneveld AB (2014) Plasma biomarkers for acute respiratory distress syndrome: a systematic review and meta-analysis. Crit Care Med 42(3):691–700

    Article  CAS  PubMed  Google Scholar 

  3. Uchida T, Shirasawa M, Ware LB, Kojima K, Hata Y, Makita K et al (2006) Receptor for advanced glycation end-products is a marker of type I cell injury in acute lung injury. Am J Respir Crit Care Med 173(9):1008–1015

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Jabaudon M, Blondonnet R, Roszyk L, Bouvier D, Audard J, Clairefond G et al (2015) Soluble RAGE predicts impaired alveolar fluid clearance in acute respiratory distress syndrome. Am J Respir Crit Care Med. doi:10.1164/rccm.201501-0020OC

  5. Calfee CS, Ware LB, Eisner MD, Parsons PE, Thompson BT, Wickersham N et al (2008) Plasma receptor for advanced glycation end-products and clinical outcomes in acute lung injury. Thorax 63:1083–1089

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Ware LB, Koyama T, Billheimer DD, Wu W, Bernard GR, Thompson BT et al (2010) Prognostic and pathogenetic value of combining clinical and biochemical indices in patients with acute lung injury. Chest 137(2):288–296

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Fremont RD, Koyama T, Calfee CS, Wu W, Dossett LA, Bossert FR et al (2010) Acute lung injury in patients with traumatic injuries: utility of a panel of biomarkers for diagnosis and pathogenesis. J Trauma 68(5):1121–1127

    Article  PubMed  PubMed Central  Google Scholar 

  8. Brown RM, Semler MW, Zhao Z, Koyama T, Janz DR, May AK et al (2015) Plasma angiopoietin-2 (Ang2) and receptor for advanced glycation end products (RAGE) improve diagnosis of ARDS compared to provider clinical assessment in adult trauma patients. Am J Respir Crit Care Med 191:A4417

    Google Scholar 

  9. Ware LB, Koyama T, Zhao Z, Janz DR, Wickersham N, Bernard GR et al (2013) Biomarkers of lung epithelial injury and inflammation distinguish severe sepsis patients with acute respiratory distress syndrome. Crit Care 17(5):R253

    Article  PubMed  PubMed Central  Google Scholar 

  10. Schnapp LM, Donohoe S, Chen J, Sunde DA, Kelly PM, Ruzinski J et al (2006) Mining the acute respiratory distress syndrome proteome: identification of the insulin-like growth factor (IGF)/IGF-binding protein-3 pathway in acute lung injury. Am J Pathol 169(1):86–95

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Rogers AJ, Matthay MA (2014) Applying metabolomics to uncover novel biology in ARDS. Am J Physiol Lung Cell Mol Physiol 306(11):L957–L961

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Gerszten RE, Accurso F, Bernard GR, Caprioli RM, Klee EW, Klee GG et al (2008) Challenges in translating plasma proteomics from bench to bedside: update from the NHLBI clinical proteomics programs. Am J Physiol Lung Cell Mol Physiol 295(1):L16–L22

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. McVey M, Tabuchi A, Kuebler WM (2012) Microparticles and acute lung injury. Am J Physiol Lung Cell Mol Physiol 303(5):L364–L381

    Article  CAS  PubMed  Google Scholar 

  14. Matthay MA, Ware LB, Zimmerman GA (2012) The acute respiratory distress syndrome. J Clin Investig 122(8):2731–2740

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Calfee CS, Janz DR, Bernard GR, May AK, Kangelaris KN, Matthay MA et al (2015) Distinct molecular phenotypes of direct vs indirect ards in single-center and multicenter studies. Chest 147(6):1539–1548

    Article  PubMed  Google Scholar 

  16. Schmidt EP, Yang Y, Janssen WJ, Gandjeva A, Perez MJ, Barthel L et al (2012) The pulmonary endothelial glycocalyx regulates neutrophil adhesion and lung injury during experimental sepsis. Nat Med 18(8):1217–1223

    Article  CAS  PubMed  Google Scholar 

  17. Brower RG, Lanken PN, MacIntyre N, Matthay MA, Morris A, Ancukiewicz M et al (2004) Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome. N Engl J Med 351(4):327–336

    Article  PubMed  Google Scholar 

  18. Wong HR, Cvijanovich NZ, Allen GL, Thomas NJ, Freishtat RJ, Anas N et al (2011) Validation of a gene expression-based subclassification strategy for pediatric septic shock. Crit Care Med 39(11):2511–2517

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Correspondence to Lorraine B. Ware.

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Ware, L.B., Calfee, C.S. Biomarkers of ARDS: what’s new?. Intensive Care Med 42, 797–799 (2016). https://doi.org/10.1007/s00134-015-3973-0

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  • DOI: https://doi.org/10.1007/s00134-015-3973-0

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