Skip to main content

Advertisement

Log in

What’s new in the quantification of causal effects from longitudinal cohort studies: a brief introduction to marginal structural models for intensivists

  • What's New in Intensive Care
  • Published:
Intensive Care Medicine Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

References

  1. Benson K, Hartz AJ (2000) A comparison of observational studies and randomized, controlled trials. N Engl J Med 342:1878–1886

    Article  CAS  PubMed  Google Scholar 

  2. Bailly S, Bouadma L, Azoulay E, Orgeas MG, Adrie C, Souweine B, Schwebel C, Maubon D, Hamidfar-Roy R, Darmon M, Wolff M, Cornet M, Timsit JF (2015) Failure of empirical systemic antifungal therapy in mechanically ventilated critically ill patients. Am J Respir Crit Care Med 191:1139–1146

    Article  CAS  PubMed  Google Scholar 

  3. Robins JM, Hernan MA, Brumback B (2000) Marginal structural models and causal inference in epidemiology. Epidemiology 11:550–560

    Article  CAS  PubMed  Google Scholar 

  4. Resche-Rigon M, Pirracchio R, Robin M, De Latour RP, Sibon D, Ades L, Ribaud P, Fermand JP, Thieblemont C, Socie G, Chevret S (2012) Estimating the treatment effect from non-randomized studies: the example of reduced intensity conditioning allogeneic stem cell transplantation in hematological diseases. BMC Blood Disord 12:10

    Article  PubMed  PubMed Central  Google Scholar 

  5. Gerhard T, Delaney JA, Cooper-Dehoff RM, Shuster J, Brumback BA, Johnson JA, Pepine CJ, Winterstein AG (2012) Comparing marginal structural models to standard methods for estimating treatment effects of antihypertensive combination therapy. BMC Med Res Methodol 12:119

    Article  PubMed  PubMed Central  Google Scholar 

  6. Bekaert M, Timsit JF, Vansteelandt S, Depuydt P, Vesin A, Garrouste-Orgeas M, Decruyenaere J, Clec’h C, Azoulay E, Benoit D (2011) Attributable mortality of ventilator-associated pneumonia: a reappraisal using causal analysis. Am J Respir Crit Care Med 184:1133–1139

    Article  PubMed  Google Scholar 

  7. Rosenbaum PR, Rubin DB (1983) The central role of the propensity score in observational studies for causal effects. Biometrika 70:41–55

    Article  Google Scholar 

  8. Pirracchio R, Carone M, Rigon MR, Caruana E, Mebazaa A, Chevret S (2013) Propensity score estimators for the average treatment effect and the average treatment effect on the treated may yield very different estimates. Stat Methods Med Res. doi:10.1177/0962280213507034

  9. Cole SR, Hernan MA (2008) Constructing inverse probability weights for marginal structural models. Am J Epidemiol 168:656–664

    Article  PubMed  PubMed Central  Google Scholar 

  10. Hernan MA, Robins JM (2006) Estimating causal effects from epidemiological data. J Epidemiol Community Health 60:578–586

    Article  PubMed  PubMed Central  Google Scholar 

  11. Hernan MA, Brumback B, Robins JM (2000) Marginal structural models to estimate the causal effect of zidovudine on the survival of HIV-positive men. Epidemiology 11:561–570

    Article  CAS  PubMed  Google Scholar 

  12. Do DP, Wang L, Elliott MR (2013) Investigating the relationship between neighborhood poverty and mortality risk: a marginal structural modeling approach. Soc Sci Med 91:58–66

    Article  PubMed  PubMed Central  Google Scholar 

  13. Yang S, Eaton CB, Lu J, Lapane KL (2014) Application of marginal structural models in pharmacoepidemiologic studies: a systematic review. Pharmacoepidemiol Drug Saf 23:560–571

    Article  PubMed  PubMed Central  Google Scholar 

  14. Muriel A, Penuelas O, Frutos-Vivar F, Arroliga A, Abraira V, Thille A, Brochard L, Nin N, Davies A, Amin P, Du B, Raymondos K, Rios F, Violi D, Maggiore S, Soares MA, Gonzalez M, Abroug F, Bulow H, Hurtado J, Kuiper M, Moreno R, Zeggwagh AA, Villagomez A, Jibaja M, Soto L, D’Empaire G, Matamis D, Koh Y, Anzueto A, Ferguson N, Esteban A (2015) Impact of sedation and analgesia during non-invasive positive pressure ventilation on outcome. A marginal structural model causal analysis. Intensive Care Med. doi:10.1007/s00134-015-3854-6

  15. Munoz ID, van der Laan M (2012) Population intervention causal effects based on stochastic interventions. Biometrics 68:541–549

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to S. Bailly.

Ethics declarations

Conflicts of interest

Authors have no conflict of interest to declare.

Electronic supplementary material

Below is the link to the electronic supplementary material.

Supplementary material 1 (DOCX 99 kb)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Bailly, S., Pirracchio, R. & Timsit, J.F. What’s new in the quantification of causal effects from longitudinal cohort studies: a brief introduction to marginal structural models for intensivists. Intensive Care Med 42, 576–579 (2016). https://doi.org/10.1007/s00134-015-3919-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00134-015-3919-6

Keywords

Navigation