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A review on Cadmium Exposure in the Population and Intervention Strategies Against Cadmium Toxicity

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Abstract

The rapid industrial development has led to serious cadmium (Cd) pollution. Cd is a toxic heavy metal placing severe health threat to human. Cd can enter the body through the atmosphere, water, soil and food, and has a long half-life (10–30 years), it largely accumulates in kidneys, liver, bone and other organs and causes irreversible damage to the target organs. Cd pollution has also further caused certain carcinogenic and non-carcinogenic health risk. This study summarizes the current situation of Cd pollution, the toxicity of specific target organs, carcinogenic risk and non-carcinogenic risk in the general population, as well as dietary supplements to prevent and mitigate Cd toxication, which aims to focus on the adverse effects of Cd to human from both individual and population perspectives, hoping that not only the health risk of Cd poisoning can be reduced, but also the accurate prevention and control of Cd poisoning can be achieved in the future.

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References

  • Amanpour P, Khodarahmi P, Salehipour M (2020) Protective effects of vitamin E on cadmium-induced apoptosis in rat testes. Naunyn-Schmiedeberg’s Arch Pharmacol 393:349–358

    Article  CAS  Google Scholar 

  • Arab-Nozari M, Mohammadi E, Shokrzadeh M, Ahangar N, Shaki F (2020) Co-exposure to non-toxic levels of cadmium and fluoride induces hepatotoxicity in rats via triggering mitochondrial oxidative damage, apoptosis, and NF-kB pathways. Environ Sci Pollut Res 27:24048–24058

    Article  CAS  Google Scholar 

  • Astolfi ML et al (2019) A prophylactic multi-strain probiotic treatment to reduce the absorption of toxic elements: in-vitro study and biomonitoring of breast milk and infant stools. Environ Int 130:104818

    Article  CAS  Google Scholar 

  • Aziz R et al (2014) impact assessment of cadmium toxicity and its bioavailability in human cell lines (Caco-2 and HL-7702). Biomed Res Int 2014:839538

    Article  Google Scholar 

  • Bhattacharya S (2020) The role of probiotics in the amelioration of cadmium toxicity. Biol Trace Elem Res 197:440–444

    Article  CAS  Google Scholar 

  • Bisanz JE, Enos MK, Mwanga JR, Changalucha J, Reid G (2014) Randomized open-label pilot study of the influence of probiotics and the gut microbiome on toxic metal levels in Tanzanian Pregnant Women and School Children. Mbio 5:e01580

    Article  CAS  Google Scholar 

  • Böhlandt A et al (2012) High concentrations of cadmium, cerium and lanthanum in indoor air due to environmental tobacco smoke. Sci Total Environ 414:738–741

    Article  CAS  Google Scholar 

  • Brzóska MM, Roszczenko A, Malgorzata G-S, Majewska K (2011) Zinc supplementation can protect from enhanced risk of femoral neck fracture in male rats chronically exposed to cadmium. Exp Toxicol Pathol 63:491–498

    Article  CAS  Google Scholar 

  • Cai K, Li C, Song Z, Gao X, Wu M (2019) Pollution and health risk assessment of carcinogenic elements As, Cd, and Cr in multiple media—A case of a sustainable farming area in China. Sustainability 11:5208

    Article  CAS  Google Scholar 

  • Chen H, Zhang W, Yang X, Wang P, Mcgrath SP, Zhao FJ (2018) Effective methods to reduce cadmium accumulation in rice grain. Chemosphere 207:699–707

    Article  CAS  Google Scholar 

  • Cheng Z et al (2017) Characteristics and health risk assessment of heavy metals exposure via household dust from urban area in Chengdu, China. Sci Total Environ 619–620:621–629

    Google Scholar 

  • Clemens S (2006) Toxic metal accumulation, responses to exposure and mechanisms of tolerance in plants. Biochimie 88:1707–1719

    Article  CAS  Google Scholar 

  • Daisley BA, Monachese M, Trinder M, Bisanz JE, Chmiel JA, Burton JP, Reid G (2019) Immobilization of cadmium and lead by Lactobacillus rhamnosus GR-1 mitigates apical-to-basolateral heavy metal translocation in a Caco-2 model of the intestinal epithelium. Gut Microbes 10:321–333

    Article  CAS  Google Scholar 

  • Djurasevic S et al (2016) The protective effects of probiotic bacteria on cadmium toxicity in rats. J Med Food 20:189–196

    Article  CAS  Google Scholar 

  • Eelco F, Paul R (2008) A chain modeling approach to estimate the impact of soil cadmium pollution on human dietary exposure. J Food Prot 71:2504–2513

    Article  Google Scholar 

  • El-Boshy M, Ashshi A, Gaith M, Qusty N, Bokhary T, Altaweel N, Abdelhady M (2017) Studies on the protective effect of the artichoke (Cynara scolymus) leaf extract against cadmium toxicity-induced oxidative stress, hepatorenal damage, and immunosuppressive and hematological disorders in rats. Environ Sci Pollut Res Int 24:12372–12383

    Article  CAS  Google Scholar 

  • Elez D, Dundjerski J, Mati G (2001) Cadmium affects the redox state of rat liver glucocorticoid receptor. Cell Biol Toxicol 17:169–177

    Article  CAS  Google Scholar 

  • Elsenhans B, Strugala G, Schafer S (1997) Small-intestinal absorption of cadmium and the significance of mucosal metallothionein. Hum Exp Toxicol 16:429–434

    Article  CAS  Google Scholar 

  • Feng P, Ye Z, Kakade A, Virk A, Li X, Liu P (2018) A review on gut remediation of selected environmental contaminants: possible roles of probiotics and gut microbiota. Nutrients 11:1–19

    Article  CAS  Google Scholar 

  • Godt J, Scheidig F, Grosse-Siestrup C, Esche V, Brandenburg P, Reich A, Groneberg DA (2006) The toxicity of cadmium and resulting hazards for human health. J Occup Med Toxicol 1:167–182

    Article  CAS  Google Scholar 

  • Grosicki A (2004) Influence of vitamin C on cadmium absorption and distribution in rats. J Trace Elem Med Biol 18:183–187

    Article  CAS  Google Scholar 

  • Hellström L, Elinder CG, Dahlberg B, Lundberg M, Järup L, Persson B, Axelson O (2001) Cadmium exposure and end-stage renal disease. Am J Kidney Dis 38:1001–1008

    Article  Google Scholar 

  • Hogervorst J et al (2007) House dust as possible route of environmental exposure to cadmium and lead in the adult general population. Environ Res 103:30–37

    Article  CAS  Google Scholar 

  • Huang Y, He C, Shen C, Guo J, Mubeen S, Yuan J, Yang Z (2017) Toxicity of cadmium and its health risks from leafy vegetable consumption. Food Funct 8:1373–1401

    Article  CAS  Google Scholar 

  • IARC (2012) Cadmium and cadmium compounds. in: IARC monographs on the evaluation of carcinogenic risks to humans. Arsenic, metals, fibres, and dusts. In: IARC Monographs. In, vol 100. International Agency for Research on Cancer, C. Lyon, France

  • Jacquillet G et al (2006) Zinc protects renal function during cadmium intoxication in the rat. Am J Physiol Renal Physiol 290:F127-137

    Article  CAS  Google Scholar 

  • Järup L, Åkesson A (2009) Current status of cadmium as an environmental health problem. Toxicol Appl Pharmacol 238:201–208

    Article  CAS  Google Scholar 

  • Järup L et al (2000) Low level exposure to cadmium and early kidney damage: the OSCAR study. Occup Environ Med 57:668–672

    Article  Google Scholar 

  • Jean J, Sirot V, Hulin M, Calvez EL, Rivière G (2018) Dietary exposure to cadmium and health risk assessment in children - Results of the French infant total diet study. Food Chem Toxicol 115:358–364

    Article  CAS  Google Scholar 

  • Jin YY, Zhou R, Kuang XY (2018) Research progress on renal injury induced by cadmium. J Environ Occup Med 35:180–184

    Google Scholar 

  • Karabulut-Bulan O, Bolkent S, Yanardag R, Bilgin-Sokmen B (2008) The role of vitamin C, vitamin E, and selenium on cadmium-induced renal toxicity of rats. Drug Chem Toxicol 31:413–426

    Article  CAS  Google Scholar 

  • Kazantzis G (2004) Cadmium, osteoporosis and calcium metabolism. Biometals 17:493–498

    Article  CAS  Google Scholar 

  • Klaassen CD, Liu J, Choudhuri S (1999) METALLOTHIONEIN: an intracellular protein to protect against cadmium toxicity. Annu Rev Pharmacol Toxicol 39:267–294

    Article  CAS  Google Scholar 

  • Kumar N, Kumar V, Panwar R, Ram C (2017) Efficacy of indigenous probiotic Lactobacillus strains to reduce cadmium bioaccessibility - An in vitro digestion model. Environ Sci Pollut Res 24:1241–1250

    Article  CAS  Google Scholar 

  • Li H, Luo N, Li YW, Cai QY, Li HY, Mo CH, Wong MH (2017) Cadmium in rice: transport mechanisms, influencing factors, and minimizing measures. Environ Pollut 224:622–630

    Article  CAS  Google Scholar 

  • Liu JG, Qu P, Zhang W, Dong Y, Li L, Wang MX (2014) Variations among rice cultivars in subcellular distribution of Cd: the relationship between translocation and grain accumulation. Environ Exp Bot 107:25–31

    Article  CAS  Google Scholar 

  • Liu Y, Xiao T, Baveye PC, Zhu J, Ning Z, Li H (2015) Potential health risk in areas with high naturally-occurring cadmium background in southwestern China. Ecotoxicol Environ Saf 112:122–131

    Article  CAS  Google Scholar 

  • Lu J, Yang X, Meng X, Wang G, Lin Y, Wang Y, Zhao F (2017) Predicting cadmium safety thresholds in soils based on cadmium uptake by Chinese cabbage. Pedosphere 27:475–481

    Article  CAS  Google Scholar 

  • Lugon-Moulin N, Zhang M, Gadani F, Rossi L, Wagner G (2004) Critical review of the scienceand options for reducing cadmium in tobacco (Nicotiana Tabacum L.) and other plants. Adv Agron 83:111–180

    Article  CAS  Google Scholar 

  • Mitra E et al (2012) Protective effect of aqueous Curry leaf (Murraya koenigii) extract against cadmium-induced oxidative stress in rat heart. Food Chem Toxicol 50:1340–1353

    Article  CAS  Google Scholar 

  • MEPC (Ministry of Environment Protection of the People’s Republic of China) (2013) Annual report of environment statistics 2012, amount of pollutants discharged in the industrial waste water. http://zls.mep.gov.cn/hjtj/nb/2012tjnb/201312/t20131225_265553.htm (In Chinese)

  • MNRC (Ministry of Natural Resources of the People’s of China) (2014) National Survey Bulletin on Soil Pollution. http://www.mlr.gov.cn/xwdt/jrxw/201404/t20140417_1312998.htm (In Chinese)

  • Monachese M, Burton JP, Reid G (2012) Bioremediation and tolerance of humans to heavy metals through microbial processes: a potential role for probiotics? Appl Environ Microbiol 78:6397–6404

    Article  CAS  Google Scholar 

  • Nawrot TS et al (2010) Cadmium exposure in the population: from health risks to strategies of prevention. Biometals 23:769–782

    Article  CAS  Google Scholar 

  • Nicholson FA, Smith SR, Alloway BJ, Carlton-Smith C, Chambers BJ (2003) An inventory of heavy metals inputs to agricultural soils in England and Wales. Sci Total Environ 311:205–219

    Article  CAS  Google Scholar 

  • Nwokocha CR et al (2012) Comparative analysis on the effect of Lycopersicon esculentum (tomato) in reducing cadmium, mercury and lead accumulation in liver. Food Chem Toxicol 50:2070–2073

    Article  CAS  Google Scholar 

  • Paniagua-Castro N, Escalona-Cardoso G, Hernández-Navarro D, Pérez-Pastén R, Chamorro-Cevallos G (2011) Spirulina (Arthrospira) protects against cadmium-induced teratogenic damage in mice. J Med Food 14:398–404

    Article  CAS  Google Scholar 

  • Perceval O, Couillard Y, Pinel-Alloul B, Bonneris E, Campbell P (2006) Long-term trends in accumulated metals (Cd, Cu and Zn) and metallothionein in bivalves from lakes within a smelter-impacted region. Sci Total Environ 369:403–418

    Article  CAS  Google Scholar 

  • Pérez Díaz MFF, Acosta M, Mohamed FH, Ferramola ML, Oliveros LB, Gimenez MS (2013) Protective effect of soybeans as protein source in the diet against cadmium-aorta redox and morphological alteration. Toxicol Appl Pharmacol 272:806–815

    Article  CAS  Google Scholar 

  • Pires VC, Gollücke APB, Ribeiro DA, Lungato L, D’Almeida V, Aguiar O (2013) Grape juice concentrate protects reproductive parameters of male rats against cadmium-induced damage: a chronic assay. Br J Nutr 110:2020–2029

    Article  CAS  Google Scholar 

  • Qasemi M et al (2019) Cadmium in groundwater consumed in the rural areas of Gonabad and Bajestan, Iran: occurrence and health risk assessment. Biol Trace Elem Res 192:106–115

    Article  CAS  Google Scholar 

  • Reeves PG, Chaney RL (2004) Marginal nutritional status of zinc, iron, and calcium increases cadmium retention in the duodenum and other organs of rats fed rice-based diets. Environ Res 96:311–322

    Article  CAS  Google Scholar 

  • Satarug S, Baker JR, Urbenjapol S, Haswell-Elkins M, Reilly PEB, Williams DJ, Moore MR (2003) A global perspective on cadmium pollution and toxicity in non-occupationally exposed population. Toxicol Lett 137:65–83

    Article  CAS  Google Scholar 

  • Satarug S, Garrett SH, Sens MA, Sens DA (2010) Cadmium, environmental exposure, and health outcomes. Environ Health Perspect 118:182–190

    Article  CAS  Google Scholar 

  • Soisungwan S (2018) Dietary cadmium intake and its effects on kidneys. Toxics 6:15

    Article  CAS  Google Scholar 

  • Staessen JA, Roels HA, Emelianov D, Kuznetsova T, Thijs L, Vangronsveld J, Fagard R (1999) Environmental exposure to cadmium, forearm bone density, and risk of fractures: prospective population study. Lancet 353:1140

    Article  CAS  Google Scholar 

  • Tinkov Alexey A, Gritsenko Viktor A, Skalnaya Margarita G, Cherkasov Sergey V, Jan A, Skalny Anatoly V (2018) Gut as a target for cadmium toxicity. Environ Pollut 235:429–434

    Article  CAS  Google Scholar 

  • Wang Z, Chai L, Wang Y, Yang Z, Wang H, Wu X (2011) Potential health risk of arsenic and cadmium in groundwater near Xiangjiang River, China: a case study for risk assessment and management of toxic substances. Environ Monit Assess 175:167–173

    Article  CAS  Google Scholar 

  • Yang H, Shu Y (2015) Cadmium transporters in the kidney and cadmium-induced nephrotoxicity. Int J Mol 16:1484–1494

    Article  CAS  Google Scholar 

  • Yang J, Ma S, Zhou J, Song Y, Li F (2018a) Heavy metal contamination in soils and vegetables and health risk assessment of inhabitants in Daye, China. J Int Med Res 46:3374–3387

    Article  CAS  Google Scholar 

  • Yang Q, Li Z, Lu X, Duan Q, Huang L, Bi J (2018b) A review of soil heavy metal pollution from industrial and agricultural regions in China: pollution and risk assessment. Sci Total Environ 642:690–700

    Article  CAS  Google Scholar 

  • Yu G, Zheng W, Wang W, Dai F, Wang Q (2017) Health risk assessment of Chinese consumers to Cadmium via dietary intake. J Trace Elem Med Biol 44:137–145

    Article  CAS  Google Scholar 

  • Yuan G et al (2014a) Toxicological assessment of combined lead and cadmium: acute and sub-chronic toxicity study in rats. Food Chem Toxicol 65:260–268

    Article  CAS  Google Scholar 

  • Yuan X, Wang J, Shang YE, Sun B (2014b) Health risk assessment of cadmium via dietary intake by adults in China. J Food Agric 94:373–380

    Article  CAS  Google Scholar 

  • Zalups RK, Ahmad S (2003) Molecular handling of cadmium in transporting epithelia. Toxicol Appl Pharmacol 186:163–188

    Article  CAS  Google Scholar 

  • Zhai Q et al (2019) Increased cadmium excretion due to oral administration of lactobacillus plantarum strains by regulating enterohepatic circulation in mice. J Agric Food Chem 67:3956–3965

    Article  CAS  Google Scholar 

  • Zhai Q, Narbad A, Chen W (2015) Dietary strategies for the treatment of cadmium and lead toxicity. Nutrients 7:552–571

    Article  CAS  Google Scholar 

  • Zhai Q, Tian F, Zhao J, Zhang H, Narbad A, Chen W (2016) Oral administration of probiotics inhibits absorption of the heavy metal cadmium by protecting the intestinal barrier. Appl Environ Microbiol 82:4429–4440

    Article  CAS  Google Scholar 

  • Zhai Q et al (2014) Protective effects of Lactobacillus plantarum CCFM8610 against chronic cadmium toxicity in mice indicate routes of protection besides intestinal sequestration. Appl Environ Microbiol 80:4063–4071

    Article  CAS  Google Scholar 

  • Zhai Q, Wang G, Zhao J, Liu X, Tian F, Zhang H, Chen W (2013) Protective effects of Lactobacillus plantarum CCFM8610 against acute cadmium toxicity in mice. Appl Environ Microbiol 79:1508–1515

    Article  CAS  Google Scholar 

  • Zhang W, Du Y, Zhai M, Shang Q (2014) Cadmium exposure and its health effects: a 19-year follow-up study of a polluted area in China. Sci Total Environ 470–471:224–228

    Article  CAS  Google Scholar 

  • Zhao X, Li Z, Tao Y, Wang D, Xing QJB (2020) Distribution characteristics, source appointment, and health risk assessment of Cd exposure via household dust in six cities of China. Build Environ 172:106728

    Article  Google Scholar 

  • Zheng N, Liu J, Wang Q, Liang Z (2010) Health risk assessment of heavy metal exposure to street dust in the zinc smelting district, Northeast of China. Sci Total Environ 408:726–733

    Article  CAS  Google Scholar 

  • Zhu G, Xiao H, Guo Q, Zhang Z, Zhao J, Yang D (2018) Effects of cadmium stress on growth and amino acid metabolism in two Compositae plants. Ecotoxicol Environ Saf 158:300–308

    Article  CAS  Google Scholar 

  • Zmora N et al (2018) Personalized gut mucosal colonization resistance to empiric probiotics is associated with unique host and microbiome features. Cell 174:1388–1405

    Article  CAS  Google Scholar 

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Acknowledgements

This work was supported by National Key Research and Development Project (2020YFC1807502), the National Natural Science Foundation of China (41822709), and Natural Science Foundation in Jiangsu province (BK20201186).

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Authors and Affiliations

  1. Key Laboratory of Environmental Medicine Engineering of Ministry of Education, School of Public Health, Southeast University, Nanjing, 210000, Jiangsu, China

    Mei Wang, Dezi Hong & Yunhui Li

  2. State Key Laboratory of Pollution Control & Resource Reuse, School of the Environment, Nanjing University, Nanjing, 210023, Jiangsu, China

    Zhaofang Chen & Lei Huang

  3. Centers for Disease Control and Prevention, Nanjing, 210093, Jiangsu, China

    Wei Song

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  1. Mei Wang
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  2. Zhaofang Chen
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Correspondence to Yunhui Li.

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Wang, M., Chen, Z., Song, W. et al. A review on Cadmium Exposure in the Population and Intervention Strategies Against Cadmium Toxicity. Bull Environ Contam Toxicol 106, 65–74 (2021). https://doi.org/10.1007/s00128-020-03088-1

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