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Clinical Events in Mad Honey Poisoning: A Single Centre Experience

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Abstract

The aim was to evaluate the clinical findings of patients who admitted to the hospital with the diagnosis of grayanotoxin/mad honey poisoning. Thirty-three patients were included in this study. Three patients were female (9%) and the others male (91%). Median age of patients was 52 (42–68). The most frequently observed findings were sinus bradycardia (91%), nausea-vomiting (81.8%), and dizziness (78.8%). Average heart rate was 55.35 ± 6.72 beats/min. Mean systolic and diastolic blood pressures were 77.86 ± 16.64 mmHg and 46.42 ± 12.30 mmHg, respectively. Mad honey poisoning is an important problem that is life-threatening in the Black Sea region of Turkey.

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References

  • Choi SH, Lee SW, Hong YS (2007) Grayanotoxin poisoning from flower of rhododendron. Bull Environ Contam Toxicol 78:11–12

    Article  CAS  Google Scholar 

  • Choo YK, Kang HY, Lim SH (2008) Cardiac problems in mad–honey intoxication. Circ J 72:1210–1211

    Article  Google Scholar 

  • Dilber E, Kalyoncu M, Yarifi N, Okten A (2002) A case of mad honey poisoning presenting with convulsion: intoxication instead of alternative therapy. Turk J Med Sci 32:361–362

    Google Scholar 

  • Dursunoglu D, Gur S, Semiz E (2007) A case with complete atrioventricular block related to mad honey intoxication. Ann Emerg Med 50:484–485

    Article  Google Scholar 

  • Eller P, Hochegger K, Tancevski I, Pechlaner C, Patsch JR (2008) Sweet heart block. Circulation 118:319

    Article  Google Scholar 

  • Gossinger H, Hruby K, Haubenstock A, Pohl A, Davogg S (1983) Cardiac arrhytmias in a patients with grayanotoxin honey poisoning. Vet Hum Toxicol 25:328–329

    CAS  Google Scholar 

  • Gunduz A, Turedi S, Uzun H, Topbas M (2006) Mad honey poisoning. Am J Emerg Med 24:595–598

    Article  Google Scholar 

  • Gunduz A, Bostan H, Turedi S, Nuhoglu I, Patan T (2007) Wild flowers and mad honey. Wilderness Environ Med 18:69–71

    Article  Google Scholar 

  • Gunduz A, Turedi S, Russell RM, Ayaz FA (2008) Clinical review of grayanotoxin/mad honey poisoning past and present. Clinical Toxicol 46:437–442

    Article  CAS  Google Scholar 

  • Kumral E, Tufekcioglu O, Aras D, Korkmaz S, Pehlivan S (2005) A rare cause of atrioventricular block: mad honey intoxication. Int J Cardiol 18:347–348

    Google Scholar 

  • Maejima H, Kinoshita E, Seyama I, Yamaoka K (2003) Distinct sites regulating grayanotoxin binding and unbinding to D4S6 of Na(v)1.4 sodium channel as revealed by improved estimation of toxin sensitivity. J Biol Chem 278:9464–9471

    Article  CAS  Google Scholar 

  • Onat FY, Yegen BC, Lawrance R, Oktay A, Oktay S (1991a) Mad honey poisoning in man and rat. Rev Environ Health 9:3–9

    CAS  Google Scholar 

  • Onat F, Yegen BC, Lawrence R, Oktay A, Oktay S (1991b) Site of action of grayanotoxins in mad honey in rats. J Appl Toxicol 11:199–201

    Article  CAS  Google Scholar 

  • Ozhan H, Akdemir R, Yazici M, Gunduz H, Duran S, Uyan C (2004) Cardiac emergencies caused by honey ingestion: a single centre experience. Emerg Med J 21:742–744

    Article  CAS  Google Scholar 

  • Poon WT, Ho CH, Yip KL, Lai CK, Cheung KL, Sung RY, Chan AY, Mak TW (2008) Grayanotoxin poisoning from Rhododendron simsii in an infant. Hong Kong Med J 14:405–407

    CAS  Google Scholar 

  • Seyama I, Yamaoka K, Yakehiro M, Yoshioka Y, Morihara K (1985) is the site of action of grayanotoxin the sodium channel gating of squid axon? Jpn J Physiol 35:401–410

    Article  CAS  Google Scholar 

  • Weiss WT, Smetana P, Nurnberg M, Huber K (2008) The honey man-Second degree heart block after honey intoxication. Int J Cardiol. doi:10.1016/jijcard.2008.11.116

  • Yavuz H, Ozel A, Akkus I, Erkul I (1991) Honey poisoning in Turkey. Lancet 337:789–790

    Article  CAS  Google Scholar 

  • Yilmaz O, Eser M, Sahiner A, Altintop L, Yesildag O (2006) Hypotension, bradycardia and syncope caused by honey poisoning. Resuscitation 6(68):405–408

    Article  Google Scholar 

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Correspondence to Ali Osman Kaya.

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Bostan, M., Bostan, H., Kaya, A.O. et al. Clinical Events in Mad Honey Poisoning: A Single Centre Experience. Bull Environ Contam Toxicol 84, 19–22 (2010). https://doi.org/10.1007/s00128-009-9906-2

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  • DOI: https://doi.org/10.1007/s00128-009-9906-2

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