Zusammenfassung
Zytokine sind zelluläre Botenstoffe, die bei einer Vielzahl von biologischen Prozessen einschließlich Immunabwehr und Reproduktion eine essentielle Rolle spielen. Seit einigen Jahren werden Zytokine zunehmend bei verschiedensten urologischen Erkrankungen im Ejakulat bestimmt. Um den aktuellen Stellenwert der Zytokindiagnostik im Ejakulat zu evaluieren, haben wir eine systematische Literatursuche im Rahmen unseres Schwerpunktes „Männliche Infertilität bei Infektion & Entzündung“ (MIBIE) durchgeführt. Aus 581 Publikationen konnten 124 Originalarbeiten mit insgesamt 31 untersuchten Zytokinen als relevant identifiziert werden, die sich in drei Kategorien einteilen ließen: Fertilität, Infektionen und chronische Prostatitis. Die Datenanalyse zeigt, dass keine Assoziation zwischen Zytokinprofilen und Ejakulatqualität bzw. Fertilität besteht. Hingegen können Zytokine bei Diagnostik und Therapiemonitoring von urogenitalen Infektionen/Entzündungen hilfreich sein. Ob es sich hierbei um einzelne oder eine Kombination verschiedener Zytokine bei den jeweiligen Krankheitsbildern handelt, müssen zukünftige Studien klären.
Abstract
Cytokines are cellular messengers which play a key role in many biological conditions such as immune defence and reproduction. During recent years analysis of seminal cytokines has become of increasing interest in various pathologies. To evaluate the current role of seminal cytokines we performed a systematic literature search within the framework of our focus group “Male Infertility during Infection and Inflammation – MIBIE”. Out of 581 manuscripts we identified 124 original articles which investigated a total of 31 different cytokines. These studies can be categorized according to the following three topics: infertility, infections and chronic prostatitis. The current analysis demonstrates that seminal cytokine profiles are not associated with either semen quality or fertility; however, cytokines might be beneficial for diagnosis and monitoring therapy in patients with urogenital infections/inflammation. Further studies are needed to clarify if a single cytokine or a combination of different cytokines is necessary to evaluate different pathologies.
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Pilatz, A., Hudemann, C., Wagenlehner, F. et al. Zytokine im Ejakulat. Urologe 52, 359–366 (2013). https://doi.org/10.1007/s00120-013-3141-5
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DOI: https://doi.org/10.1007/s00120-013-3141-5