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Hoch intensiver fokussierter transrektaler Ultraschall (rHIFU) zur lokalen Therapie des Prostatakarzinoms

Update 2009

Transrectal high-intensity focused ultrasound for local treatment of prostate cancer

2009 Update

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Zusammenfassung

Gepulster fokussierter, robotischer hoch intensiver Ultraschall (rHIFU) ist v. a. aufgrund seines nicht invasiven Therapiecharakters interessant. In der urologischen Onkologie findet rHIFU als therapeutische Maßnahme zur transrektalen Behandlung des Prostatakarzinoms Anwendung. Während die perkutane Therapie des Nierenkarzinoms derzeit noch in experimentell klinischen Studien geprüft wird, ist die transrektale Therapie mit rHIFU bereits in über 230 urologischen Abteilungen weltweit als Therapieoption des Prostatakarzinoms etabliert. Die Ergebnisse der Therapie des Prostatakarzinoms mit rHIFU basieren in der Hauptsache auf Patientenserien unterschiedlicher klinischer Studien. In den USA wurde vor 2 Jahren eine prospektive Multicenterstudie für die klinische Zulassung (FDA Approval) begonnen (Vergleich HIFU/Kryotherapie). Die neuesten Publikationen sehen in der transrektalen Anwendung von rHIFU eine Erfolg versprechende zusätzliche Therapieoption beim lokalen Prostatakarzinom, bei lokalen Rezidiven jedweder erfolgloser Primärtherapien, sowie als palliativ adjuvante Zusatztherapie des systemischen Prostatakarzinoms.

Abstract

Pulsed robotic high-intensity focused ultrasound (rHIFU) is an interesting therapeutic option mainly due to its noninvasive character. In urologic oncology, rHIFU is used for the transrectal therapy of prostate cancer. While percutaneous therapy of renal cancer using rHIFU is still being tested in experimental studies, transrectal therapy with rHIFU for prostate cancer is already established in more than 230 urologic departments worldwide. The results of prostate cancer therapy with rHIFU are mainly based on different clinical studies. In 2007 a clinical study comparing rHIFU and cryotherapy for the treatment of prostate cancer was initiated in the USA in order to gain clinical approval by the FDA. The most recent publications concluded that the use of rHIFU is an effective standard treatment for prostate cancer with a broad range of indications in all tumor stages: (1) in the primary treatment of local prostate cancer, (2) in patients with local recurrence after failure of any primary treatment, and (3) as an adjuvant therapy in the palliation of systemic prostate cancer.

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Interessenkonflikt

Der korrespondierende Autor weist auf folgende Beziehung/en hin: Principal Investigator seit 1996. HIFU Studienbetreiber. Trotz des möglichen Interessenkonflikts ist der Beitrag unabhängig und produktneutral.

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Authors and Affiliations

  1. Klinik für Urologie, Klinikum Harlaching, Sanatoriumsplatz 2, 81545, München, Deutschland

    C.G. Chaussy FRCS & S. Thüroff

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  1. C.G. Chaussy FRCS
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  2. S. Thüroff
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Correspondence to C.G. Chaussy FRCS.

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Chaussy, C., Thüroff, S. Hoch intensiver fokussierter transrektaler Ultraschall (rHIFU) zur lokalen Therapie des Prostatakarzinoms. Urologe 48, 710–718 (2009). https://doi.org/10.1007/s00120-009-1981-9

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