Zusammenfassung
Die Organ erhaltende Nierentumorchirurgie hat in den letzten 20 Jahren immer mehr an Bedeutung gewonnen. Zunächst wurde sie unter imperativer Indikation zum Erhalt der Restnierenfunktion durchgeführt, mittlerweile wird aufgrund guter onkologischer Ergebnisse zunehmend auch unter elektiven Indikationsstellungen teilreseziert. Nach den neuen EAU-Leitlinien für Nierenzellkarzinome hat sich die Nierenteilresektion bei Tumoren unter 4 cm und gesunder kontralateraler Niere – aufgrund zur Nephrektomie vergleichbar guter Ergebnisse – als Standardtherapie etabliert. In großen urologischen Zentren wird mittlerweile eine Teilresektion auch bei Tumoren über 4 cm bei günstiger Tumorlokalisation und entsprechender technischer Durchführbarkeit favorisiert – so genannte erweiterte elektive Indikationsstellung. Im Folgenden sollen die Indikationen zur Nierenteilresektion, das perioperative Vorgehen, verschiedene operative Techniken und Zugangswege sowie onkologische Ergebnisse vor dem Hintergrund der Daten aus der eigenen Klinik dargestellt werden.
Abstract
Over the last two decades, nephron-sparing surgery has gained more and more importance. Initially it was done for imperative indications to preserve the remaining function of solitary kidneys. Today, because of favourable oncological results, elective nephron-sparing surgery is increasingly performed. According to the latest European Association of Urology guidelines on renal cell carcinoma, nephron-sparing surgery for tumours less than 4 cm with a healthy contralateral kidney is considered the standard therapeutic option because of excellent postoperative outcome and favourable oncological results. At major urological institutions, nephron-sparing surgery is even offered to patients with tumours larger than 4 cm (easy access, with partial resection deemed oncologically and technically feasible) for so-called extended elective indications. This review summarises the indications, perioperative management, various surgical approaches and techniques, and oncological results for nephron-sparing surgery, briefly highlighting data from our own institution.
Literatur
Becker F, Siemer S, Hack M et al. (2006) Elective nephron sparing surgery should become standard treatment for small unilateral renal cell carcinoma: long-term survival data of 216 patients. Eur Urol 49: 308–313
Becker F, Siemer S, Hack M et al. (2006) Excellent long-term cancer control with elective nephron-sparing surgery for selected renal cell carcinomas measuring more than 4 cm. Eur Urol 49: 1058–1064
Becker F, Suttmann H, Siemer S et al. (2006) Is there a place for surveillance in the management of small renal tumors? Nat Clin Pract Urol 3: 626–627
Coll MC, Smith RC (2007) Update on radicological imaging of renal cell carcinoma. BJU Int 99: 1217–1222
Fergany A, Hafez K, Novick AC (2000) Long-term results of nephron sparing surgery for localized renal cell carcinoma: 10-year follow up. J Urol 163: 442–445
Fergany A, Saad I, Woo L et al. (2006) Open partial nephrectomy for tumor in a solitary kidney: experience with 400 cases. J Urol 175: 1630–1633
Heidenreich A, Ravery V, European Society of Oncological Urology (2004) Preoperative imaging in renal cell cancer. World J Urol 22: 307–315
Humke U (1999) Die pharmakologische Blockade des Renin-Angiotensin-Systems in der Prävention des postischämischen akuten Nierenversagens. Aktuelle Urol 30: 476–491
Humke U (2001) Die organerhaltende Nierentumorchirurgie – Bericht eines wissenschaftlichen Symposiums. Shaker, Aachen
Kato M, Suzuki T, Suzuki Y et al. (2004) Natural history of small renal cell carcinoma: evaluation of growth rate, histological grade, cell proliferation and apoptosis. J Urol 172: 863–866
Lane BR, Novick AC (2007) Nephron-sparing surgery. BJU Int 99: 1245–1250
Leibovich BC, Blute ML, Cheville JC et al. (2004) Nephron sparing surgery for appropriately selected renal cell carcinoma between 4 and 7 cm results in outcome similar to radical nephrectomy. J Urol 171: 1066–1070
Lindblad P (2004) Epidemiology of renal cell carcinoma. Scand J Surg 93: 88–96
Ljungberg B, Hanbury DC, Kuczyk MA et al. European Association of Urology Guideline Group for Renal Cell Carcinoma (2007) Renal cell carcinoma guidelines. Eur Urol 51: 1502–1510
Novick AC (2002) Nephron-sparing surgery for renal cell carcinoma. Annu Rev Med 53: 393–407
Pahernik S, Roos F, Hampel C et al. (2006) Nephron sparing surgery for renal cell carcinoma with normal contralateral kidney. J Urol 175: 2027–2031
Pattard JJ, Rodriquez A, Rioux-Leclercq N et al. (2002) Prognostic significance of the mode of detection in renal tumours. BJU Int 90: 358–363
Poulakis V, Witzsch U, De Vries R et al. (2003) Quality of life after surgery for localized renal cell carcinoma: comparison between radical nephrectomy and nephron-sparing surgery. Urology 62: 814–820
Robson CJ, Churchill BM, Anderson W (1969) The results of radical nephrectomy for renal cell carcinoma. J Urol101: 297–301
Shekarriz B, Upadhyay J, Shekarriz H et al. (2002) Comparison of costs and complications of radical and partial nephrectomy for treatment of localized renal cell carcinoma. Urology 59: 211–215
Siemer S, Lahme S, Altziebler S et al. (2007) Efficacy and safety of TachoSil® as haemostatic treatment versus standard suturing in kidney tumour resection: a randomised prospective study. Eur Urol 53: 1156–1163
Steffens J, Humke U, Ziegler M et al. (2005) Partial nephrectomy with perfusion cooling for imperative indications: a 24-year experience. BJU Int 96: 608–611
Uzzo RG, Novick AC (2001) Nephron sparing surgery for renal tumors: indications, techniques and outcomes. J Urol 166: 6–18
Interessenkonflikt
Der korrespondierende Autor gibt an, dass kein Interessenkonflikt besteht.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Becker, F., Siemer, S., Rotering, J. et al. Organ erhaltende Nierentumorchirurgie. Urologe 47, 215–223 (2008). https://doi.org/10.1007/s00120-008-1651-3
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00120-008-1651-3