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Liquordiagnostik bei Multipler Sklerose

Cerebrospinal fluid diagnostics in multiple sclerosis

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Zusammenfassung

Die Multiple Sklerose (MS) geht als chronisch-entzündliche Erkrankung des zentralen Nervensystems (ZNS) mit typischen Veränderungen im Liquor einher. In der Diagnostik der MS ist die Liquoruntersuchung daher neben der Magnetresonanztomographie ein zentrales Verfahren, welches einerseits die Diagnose einer MS untermauern und andererseits hilfreich in der Abgrenzung von Differenzialdiagnosen sein kann. Der wichtigste Liquorbefund bei der MS ist der Nachweis einer persistierenden polyspezifischen intrathekalen Immunglobulinsynthese. Diese Übersichtsarbeit gibt einen Überblick über Liquorbefunde bei der MS, weist auf praxisrelevante Aspekte und diagnostische Fallstricke hin und stellt neue Entwicklungen in der Liquordiagnostik bei der MS dar.

Abstract

As a chronic inflammatory disease of the central nervous system (CNS), multiple sclerosis (MS) is associated with characteristic abnormalities in cerebrospinal fluid (CSF). Thus, in addition to magnetic resonance imaging, CSF examination is a central diagnostic procedure in patients with MS, which can corroborate a diagnosis of MS and may also help to discern differential diagnoses. The most important CSF finding in MS is the detection of persistent polyspecific intrathecal immunoglobulin synthesis. This review summarizes CSF findings of patients with MS and addresses issues of relevance for clinical practice, potential diagnostic pitfalls as well as new developments in CSF diagnostics of MS.

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Authors and Affiliations

  1. Klinik für Neurologie, Klinisches und Experimentelles Forschungszentrum für Multiple Sklerose, Charité – Universitätsmedizin Berlin, Berlin, Deutschland

    K. Ruprecht

  2. Fachklinik für Neurologie Dietenbronn, Dietenbronn 7, 88477, Schwendi, Deutschland

    H. Tumani

  3. Neurologische Universitätsklinik im RKU, Oberer Eselsberg 45, 89081, Ulm, Deutschland

    H. Tumani

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  1. K. Ruprecht
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Correspondence to H. Tumani.

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K. Ruprecht und H. Tumani geben an, dass kein Interessenkonflikt besteht.

Dieser Beitrag beinhaltet keine von den Autoren durchgeführten Studien an Menschen oder Tieren.

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Ruprecht, K., Tumani, H. Liquordiagnostik bei Multipler Sklerose. Nervenarzt 87, 1282–1287 (2016). https://doi.org/10.1007/s00115-016-0220-z

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