Zusammenfassung
Das Schlaf-Apnoe-Syndrom ist bekanntermaßen mit einer erhöhten Koinzidenz von kardialen und zerebralen Infarkten vergesellschaftet. In unserer Kasuistik berichten wir von beidseitigen Palliduminfarkten. Diese gelten in der Literatur als typisch für eine plötzliche Asphyxie, etwa nach Herzstillstand oder Kohlenmonoxidvergiftung. Einige epidemiologische und pathophysiologische Beobachtungen werden zitiert.
Summary
Patients suffering from sleep apnea syndrome are known to be at higher risk of cardiac and cerebral infarction. In this case report, we describe bilateral pallidal lesions, which are normally seen after sudden asphyxia due to cardiac arrest or carbon monoxide intoxication. Some epidemiological and pathophysiological observations are cited.
This is a preview of subscription content, log in via an institution to check access.
Literatur
Auer RN, Sutherland GR (2002) Hypoxia and related conditions. In: Graham DI, Lantos PL (eds) Greenfield’s neuropathology. Arnold, London, pp 233–280
Balfors EM, Franklin KA (1994) Impairment of cerebral perfusion during obstructive sleep apneas. Am J Respir Crit Care Med 150:1587–1591
Bokinsky G, Miller M, Ault K et al. (1995) Spontaneous platelet activation and aggregation during obstructive sleep apnea and its response to therapy. Chest 108:625–630
Bucci FA, Krohel GB (1986) Optic nerve swelling secondary to the obstructive sleep apnea syndrome. Am J Ophthalmol 105:428–430
Calhoun DA, Nishizaka MK, Zaman MA et al. (2004) Aldosterone excretion among subjects with resistant hypertension and symptoms of sleep apnea. Chest 125:112–117
Diomedi M, Placidi F, Cupini LM et al. (1998) Cerebral hemodynamic changes in sleep apnea syndrome and effect of continuous positiv airway pressure. Neurology 51:1051–1056
Dyken ME, Somers VK, Yamada T et al. (1996) Investigating the relationship between stroke and obstructive sleep apnea. Stroke 27:401–407
Elliott WJ (1998) Circadian variation in the timing of stroke onset. A meta-analysis. Stroke 29:992–996
Geiser T, Buck F, Meyer BJ et al. (2002) In vivo platelet activation is increased during sleep in patients with obstructive sleep apnea syndrome. Respiration 69:229–234
Guilleminault C, Kreutzer M, Chang JL (2004) Pregnancy, sleep disordered breathing and treatment with nasal continuous positive airway pressure. Sleep Med 5:43–51
Hla KM, Young TB, Bidwell T et al. (1994) Sleep apnea and hypertension. Ann Intern Med 120:382–388
Hung J, Whitford EG, Parsons RW et al. (1990) Association of sleep apnea with myocardial infarction in men. Lancet 336:261–264
Jennum P, Borgesen SE (1989) Intracranial pressure and obstructive sleep apnea. Chest 95:279–283
Kraczi H, Hedner J, Peker Y et al. (2000) Increased vasoconstrictor sensitivity in obstructive sleep apnea. J Appl Physiol 89:493–498
Lavie P, Herer P, Hoffstein V (2000) Obstructive sleep apnea syndrome as a risk factor for hypertension: population study. BMJ 320:479–482
Loeppky JA, Miranda FG, Eldridge MW (1984) Abnormal cerebrovascular responses to CO2 in sleep apnea patients. Sleep 7:97–109
Manni R, Terzaghi M, Arbasino C et al. (2003) Obstructive sleep apnea in a clinical series of adult epilepsy patients: frequency and features of the comorbidity. Epilepsia 44:836–840
Marks MP (2002) Cerebral ischemia and infarction. In: Atlas SW (ed) Magnetic resonance imaging of the brain and spine. Lippincott Williams & Wilkins, Philadelphia, pp 919–979
Marsh EE, Biller J, Adams HP et al. (1990) Circadian variation in onset of acute ischemic stroke. Arch Neurol 47:1178–1180
Mohsenin V (2001) Sleep-related breathing disorders and risk of stroke. Stroke 32:1271–1278
Mojon DS, Mathis J, Zulauf M et al. (1998) Optic neuropathy associated with sleep apnea syndrome. Ophthalmology 105:874–877
Mojon DS, Hess CW, Goldblum D et al. (2000) Primary open-angle glaucoma is associated with sleep apnea syndrome. Ophthalmologica 214:115–118
Neubauer JA (2001) Physiological and pathophysiological responses to intermittent hypoxia. J Appl Physiol 90:1593–1599
Nieto FJ, Young TB, Lind BK et al. (2000) Association of sleep-disordered breathing, sleep apnea, and hypertension. JAMA 283:1829–1836
Ohayon MM, Guilleminault C, Priest RG et al. (2000) Is sleep-disordered breathing an independent risk factor for hypertension in the general population (13,057 subjects)? J Psychosom Res 48:593–601
Palomäki H (1991) Snoring and the risk of ischemic brain infarction. Stroke 22:1021–1025
Peppard PE, Young T, Palta M et al. (2000) Prospective study of the association between sleep-disordered breathing and hypertension. N Engl J Med 342:1378–1384
Stradling JR, Davis RJO (2004) Obstructive sleep apnea/hypopnea syndrome: definitions, epidemiology, and natural history. Thorax 59:73–78
Tofler GH, Brezinski D, Schafer AI et al. (1987) Concurrent morning increase in platelet aggregability and the risk of myocardial infarction and sudden cardiac death. N Engl J Med 316:1514–1518
Van den Aardweg JG, Karemaker JM (1992) Repetitive apneas induce periodic hypertension in normal subjects through hypoxia. J Appl Physiol 72:821–827
Young T, Palta M, Dempsey J et al. (1993) The occurrence of sleep-disordered breathing among middle-aged adults. N Engl J Med 328:1230–1235
Ziegler MG, Nelesen RA, Mills PJ et al. (1995) The effect of hypoxia on baroreflexes and pressor sensitivity in sleep apnea and hypertension. Sleep 18:859–865
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Egan, P.J., Becker, FW. & Bundt, R. Bilaterale Palliduminfarkte bei Schlaf-Apnoe-Syndrom. Nervenarzt 76, 1539–1541 (2005). https://doi.org/10.1007/s00115-005-1930-9
Issue Date:
DOI: https://doi.org/10.1007/s00115-005-1930-9