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Asthma bronchiale im Kindesalter

Bronchial asthma in childhood

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Zusammenfassung

Asthma bronchiale ist in den westlichen Industrienationen die häufigste chronische Erkrankung im Kindesalter und betrifft in Deutschland etwa 10 % aller Kinder. Im Fokus dieses Artikels stehen die praxisrelevanten Grundlagen zu Diagnose und Therapie des Asthma bronchiale, die besonderen Herausforderungen der Atemwegsobstruktion im Kleinkindalter und aktuelle Studien zur Therapie.

Abstract

Asthma is the most common chronic disease of children living in industrialized countries and has a prevalence of 10 % among children in Germany. The report focuses on the basics of and recent advances in clinical diagnosis and therapy of asthma with special emphasis on the special challenges in the evaluation and treatment of preschool children with recurrent wheeze.

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Literatur

  1. Wenzel SE (2012) Asthma phenotypes: the evolution from clinical to molecular approaches. Nat Med 18(5):716–725

    Article  PubMed  CAS  Google Scholar 

  2. Asher MI et al (2006) Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys. Lancet 368(9537):733–743

    Article  PubMed  Google Scholar 

  3. Martinez FD et al (1995) Asthma and wheezing in the first six years of life. The Group Health Medical Associates. N Engl J Med 332(3):133–138

    Article  PubMed  CAS  Google Scholar 

  4. Castro-Rodriguez JA (2011) The Asthma Predictive Index: early diagnosis of asthma. Curr Opin Allergy Clin Immunol 11(3):157–161

    Article  PubMed  Google Scholar 

  5. Guilbert TW et al (2006) Long-term inhaled corticosteroids in preschool children at high risk for asthma. N Engl J Med 354(19):1985–1997

    Article  PubMed  CAS  Google Scholar 

  6. Guilbert TW et al (2004) Atopic characteristics of children with recurrent wheezing at high risk for the development of childhood asthma. J Allergy Clin Immunol 114:1282−1287

    Article  PubMed  Google Scholar 

  7. Mackay D et al (2010) Smoke-free legislation and hospitalizations for childhood asthma. N Engl J Med 363(12):1139–1145

    Article  PubMed  CAS  Google Scholar 

  8. Jackson DJ et al (2012) Evidence for a causal relationship between allergic sensitization and rhinovirus wheezing in early life. Am J Respir Crit Care Med 185(3):281–285

    Article  PubMed  Google Scholar 

  9. Bisgaard H et al (2007) Childhood asthma after bacterial colonization of the airway in neonates. N Engl J Med 357(15):1487–1495

    Article  PubMed  CAS  Google Scholar 

  10. Hilty M et al (2010) Disordered microbial communities in asthmatic airways. PLoS One 5(1):e8578

    Article  PubMed  Google Scholar 

  11. Castro-Rodriguez JA, Rodrigo GJ (2009) Efficacy of inhaled corticosteroids in infants and preschoolers with recurrent wheezing and asthma: a systematic review with meta-analysis. Pediatrics 123(3):e519–e525

    Article  PubMed  Google Scholar 

  12. Kelly HW et al (2012) Effect of inhaled glucocorticoids in childhood on adult height. N Engl J Med 367(10):904–912

    Article  PubMed  CAS  Google Scholar 

  13. Guilbert TW et al (2011) Growth of preschool children at high risk for asthma 2 years after discontinuation of fluticasone. J Allergy Clin Immunol 128(5):956–963 e1–e7

    Article  PubMed  Google Scholar 

  14. Bacharier LB et al (2008) Episodic use of an inhaled corticosteroid or leukotriene receptor antagonist in preschool children with moderate-to-severe intermittent wheezing. J Allergy Clin Immunol 122(6):1127–1135 e8

    Article  PubMed  CAS  Google Scholar 

  15. Zeiger RS et al (2011) Daily or intermittent budesonide in preschool children with recurrent wheezing. N Engl J Med 365(21):1990–2001

    Article  PubMed  CAS  Google Scholar 

  16. Bacharier LB, Guilbert TW (2012) Diagnosis and management of early asthma in preschool-aged children. J Allergy Clin Immunol 130(2):287–296 (quiz 297–298)

    Article  PubMed  Google Scholar 

  17. Murray CS et al (2006) Secondary prevention of asthma by the use of Inhaled Fluticasone propionate in Wheezy INfants (IFWIN): double-blind, randomised, controlled study. Lancet 368(9537):754–762

    Article  PubMed  CAS  Google Scholar 

  18. Bisgaard H et al (2006) Intermittent inhaled corticosteroids in infants with episodic wheezing. N Engl J Med 354(19):1998–2005

    Article  PubMed  CAS  Google Scholar 

  19. Lemanske RF Jr et al (2010) Step-up therapy for children with uncontrolled asthma receiving inhaled corticosteroids. N Engl J Med 362(11):975–985

    Article  PubMed  CAS  Google Scholar 

  20. Bush A et al (2008) Severe childhood asthma: a common international approach? Lancet 372(9643):1019–1021

    Article  PubMed  Google Scholar 

  21. Bracken M et al (2009) The importance of nurse-led home visits in the assessment of children with problematic asthma. Arch Dis Child 94(10):780–784

    Article  PubMed  CAS  Google Scholar 

  22. Busse WW et al (2011) Randomized trial of omalizumab (anti-IgE) for asthma in inner-city children. N Engl J Med 364(11):1005–1015

    Article  PubMed  CAS  Google Scholar 

  23. Hedlin G, Konradsen J, Bush A (2012) An update on paediatric asthma. Eur Respir Rev 21(125):175–185

    Article  PubMed  Google Scholar 

  24. Peters SP et al (2010) Tiotropium bromide step-up therapy for adults with uncontrolled asthma. N Engl J Med 363(18):1715–1726

    Article  PubMed  CAS  Google Scholar 

  25. Wenzel S et al (2007) Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: results of two phase 2a studies. Lancet 370(9596):1422–1431

    Article  PubMed  CAS  Google Scholar 

  26. Corren J et al (201) Lebrikizumab treatment in adults with asthma. N Engl J Med 365(12):1088–1098

    Article  Google Scholar 

  27. Castro M et al (2011) Reslizumab for poorly controlled, eosinophilic asthma: a randomized, placebo-controlled study. Am J Respir Crit Care Med 184(10):1125–1132

    Article  PubMed  CAS  Google Scholar 

  28. Woodruff PG et al (2009) T-helper type 2-driven inflammation defines major subphenotypes of asthma. Am J Respir Crit Care Med 180(5):388–395

    Article  PubMed  CAS  Google Scholar 

  29. Woodruff PG et al (2007) Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids. Proc Natl Acad Sci U S A 104(40):15858–15863

    Article  PubMed  CAS  Google Scholar 

  30. Ege MJ et al (2011) Exposure to environmental microorganisms and childhood asthma. N Engl J Med 364(8):701–709

    Article  PubMed  CAS  Google Scholar 

  31. Edlmayr J et al (2009) A combination vaccine for allergy and rhinovirus infections based on rhinovirus-derived surface protein VP1 and a nonallergenic peptide of the major timothy grass pollen allergen Phl p 1. J Immunol 182(10):6298–6306

    Article  PubMed  CAS  Google Scholar 

  32. Gupta A et al (2011) Relationship between serum vitamin D, disease severity, and airway remodeling in children with asthma. Am J Respir Crit Care Med 184(12):1342–1349

    Article  PubMed  CAS  Google Scholar 

  33. Laube BL et al (2011) What the pulmonary specialist should know about the new inhalation therapies. Eur Respir J 37(6):1308–1331

    Article  PubMed  CAS  Google Scholar 

  34. Brand PL et al (2008) Definition, assessment and treatment of wheezing disorders in preschool children: an evidence-based approach. Eur Respir J 32(4):1096–1110

    Article  PubMed  CAS  Google Scholar 

  35. Lai CKW et al. (2009) Global variation in the prevalence and severity of asthma symptoms: phase three of the international study of asthma and allergies in childhood (ISAAC). Thorax 65: 476-483

    Article  Google Scholar 

  36. http://www.versorgungsleitlinien.de/themen/asthma/pdf/nvl_asthma_lang.pdf

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Interessenkonflikt

Der korrespondierende Autor weist für sich und seine Koautoren auf folgende Beziehung/en hin: Fa Novartis: bezahlte Vorträge, beratende Tätigkeit, finanzierte Reisen zu Kongressen (Gegenleistung: Vorträge); MSD, Bencard: bezahlte Vorträge; Allergopharma: bezahlte Beiträge im Quartheft (Herausgeber Allergopharma); InfectopPharm: bezahlte Vorträge, Organisation und Gestaltung von Fortbildungsveranstaltungen.

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  1. Klinik für Pädiatrische Pneumologie, Allergologie und Neonatologie, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Deutschland

    G. Hansen & N. Schwerk

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  1. G. Hansen
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  2. N. Schwerk
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Correspondence to G. Hansen.

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Hansen, G., Schwerk, N. Asthma bronchiale im Kindesalter. Monatsschr Kinderheilkd 161, 390–398 (2013). https://doi.org/10.1007/s00112-012-2799-x

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  • DOI: https://doi.org/10.1007/s00112-012-2799-x

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