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An emerging role of PARK2 in cancer

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Abstract

PARK2 (PARKIN) is an E3 ubiquitin ligase involved in multiple signaling pathways and cellular processes. Activity of PARK2 is tightly regulated through inter- and intra-molecular interactions. Dysfunction of PARK2 is associated with the progression of parkinsonism. Notably, frequent PARK2 inactivation has been identified in various human cancers. Park2-deficient mice are more susceptible to tumorigenesis, indicating its crucial role as a tumor suppressor. However, biological studies also show that PARK2 possesses both pro-survival and growth suppressive functions. Here, we summarize the genetic lesions of PARK2 in human cancers and discuss the current knowledge of PARK2 in cancer progression. We further highlight future efforts for the study of PARK2 in cancer.

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Acknowledgments

We thank Chen Ye for the kind help in generation figures. This work was funded by the Singapore Ministry of Health's National Medical Research Council (NMRC) under its Singapore Translational Research (STaR) Investigator Award to H. Phillip Koeffler, NMRC Individual Research Grant (NMRC/1311/2011), and NIH grant R01CA026038-23. This work was also partially supported by grants from the Natural Science Foundation of China (81071788, 81272956).

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The authors declare no conflict of interest related to this study.

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Authors and Affiliations

  1. Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore

    Liang Xu, De-chen Lin & H. Phillip Koeffler

  2. Division of Hematology and Oncology, Cedars-Sinai Medical Center, UCLA School of Medicine, Los Angeles, CA, 90048, USA

    De-chen Lin & H. Phillip Koeffler

  3. Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China

    Dong Yin

  4. National Cancer Institute of Singapore, National University of Singapore, Singapore, 119228, Singapore

    H. Phillip Koeffler

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  1. Liang Xu
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  2. De-chen Lin
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  4. H. Phillip Koeffler
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Correspondence to De-chen Lin or Dong Yin.

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Xu, L., Lin, Dc., Yin, D. et al. An emerging role of PARK2 in cancer. J Mol Med 92, 31–42 (2014). https://doi.org/10.1007/s00109-013-1107-0

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