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Molecular biology for formyl peptide receptors in human diseases

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Abstract

Leukocytes accumulate at sites of inflammation and immunological reaction in response to locally existing chemotactic mediators. The first chemotactic factors structurally defined were N-formyl peptides. Subsequently, numerous ligands were identified to activate formyl peptide receptors (FPRs) that belong to the seven-transmembrane G protein-coupled receptor superfamily. FPRs interact with this menagerie of structurally diverse pro- and anti-inflammatory ligands to possess important regulatory effects in multiple diseases, including inflammation, amyloidosis, Alzheimer’s disease, prion disease, acquired immunodeficiency syndrome, obesity, diabetes, and cancer. How these receptors recognize diverse ligands and how they contribute to disease pathogenesis and host defense are basic questions currently under investigation that would open up new avenues for the future management of inflammation-related diseases.

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Acknowledgments

This work was supported by National Natural Science Foundation of China Grants no. 30570726, 30772154, and 30972797.

Conflicts of interest statement

The authors declare that there are no conflicts of interest.

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  1. Department of Pathophysiology, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, Hubei, 430030, China

    Yongsheng Li & Duyun Ye

  2. Department of Anesthesiology, Center for Experimental Therapeutics and Reperfusion Injury, Perioperative and Pain Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, 02115, USA

    Yongsheng Li

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  1. Yongsheng Li
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  2. Duyun Ye
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Correspondence to Yongsheng Li or Duyun Ye.

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Li, Y., Ye, D. Molecular biology for formyl peptide receptors in human diseases. J Mol Med 91, 781–789 (2013). https://doi.org/10.1007/s00109-013-1005-5

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  • DOI: https://doi.org/10.1007/s00109-013-1005-5

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