Abstract
The protein “missing in metastasis”, known as MIM, has been characterised as an actin-binding scaffold protein that may be involved in cancer metastasis. In this paper, we summarise the literature surrounding the role of MIM in actin and membrane dynamics and in signalling to transcription via the sonic hedgehog pathway. MIM is postulated to have many potential activities, including a BAR-like domain termed the IMD (IRS-MIM domain), which can interact with membranes to induce membrane deformation and also with actin and the small GTPase Rac. How this multifunctional protein and its close relative ABBA-1 regulate cellular behaviour is still very much an open question.
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Acknowledgements
We thank Roberto Dominguez of the University of Pennsylvania School of Medicine for helpful discussions and for providing the materials for Fig. 3. We also thank the Medical Research Council UK and the Association for International Cancer Research for funding.
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Machesky, L.M., Johnston, S.A. MIM: a multifunctional scaffold protein. J Mol Med 85, 569–576 (2007). https://doi.org/10.1007/s00109-007-0207-0
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DOI: https://doi.org/10.1007/s00109-007-0207-0