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Drohende Cumarinnekrose bei einer 24-jährigen Patientin mit stattgehabter Beinvenenthrombose

Impending Coumarin-necrosis in a patient with heterozygous protein C deficiency type I

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Zusammenfassung

Schmerzhafte, rosa- bis purpurfarbene, gegenüber der Umgebung scharf abgegrenzte Hautveränderungen sollten unter laufender Cumarintherapie an eine beginnende Cumarinnekrose denken lassen. Eine Substitution mit einem Protein-C-Präparat kann die Ausbildung von Nekrosen bei Patienten mit nachgewiesenem Protein-C-Mangel verhindern.

Abstract

Painful pink or magenta colored skin lesions characterized by a clear line of demarcation between the affected area and surrounding tissue appearing under therapy with coumarins may be a sign for evolving coumarin-necrosis. Immediate treatment with a protein C preparation in patients with protein C deficiency can prevent necrosis.

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Authors and Affiliations

  1. II. Medizinische Klinik, Klinikum Augsburg, Stenglinstraße 2, 86156, Augsburg, Deutschland

    R. Schulze, S. Harwix, K. Murmann & G. Schlimok

  2. I. Medizinische Klinik, Klinikum Augsburg, Augsburg, Deutschland

    H. Wittwer & W. v. Scheidt

  3. Institut für Laboratoriumsmedizin, Klinikum Augsburg, Augsburg, Deutschland

    W. Behr & W. Ehret

Authors
  1. R. Schulze
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  2. W. Behr
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  3. H. Wittwer
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  4. S. Harwix
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  5. K. Murmann
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  6. W. v. Scheidt
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  7. W. Ehret
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  8. G. Schlimok
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Correspondence to R. Schulze.

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Schulze, R., Behr, W., Wittwer, H. et al. Drohende Cumarinnekrose bei einer 24-jährigen Patientin mit stattgehabter Beinvenenthrombose. Internist 49, 618–622 (2008). https://doi.org/10.1007/s00108-008-2119-7

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  • DOI: https://doi.org/10.1007/s00108-008-2119-7

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