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Zur oromandibulären, pharyngealen und laryngealen Anwendung von Botulinumtoxin

The application of botulinum toxin in oromandibular, pharyngeal and laryngeal dystonia

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Zusammenfassung

Dystonien der Muskulatur des Mundes, des Rachens und des Kehlkopfs können klinisch sowohl Schluck- als auch Atem- und Kommunikationsstörungen bewirken. Neben den funktionellen Störungen beim Kauen, Schlucken, Sprechen und der Stimme sind bei äußerlich sichtbaren oder hörbaren Dystonien Stigmatisierungen und soziale Nachteile möglich. Symptomatische und zeitlich begrenzte therapeutische Effekte können durch gezielte Injektionen von Botulinumtoxin in die dystone Muskulatur erreicht werden. Mögliche Anwendungsbereiche sind die oromandibuläre Dystonie, der Palatoklonus, Dysphagien sowie laryngeale Dystonien, bei denen die spasmodische Dysphonie die häufigste Form darstellt.

Abstract

Dystonias of the oral, pharyngeal and laryngeal muscles are potential causes of deglutitive, respiratory and communicative disorders. In addition to functional deficits such as dysphagia, dysarthria and dysphonia, social disadvantages may arise from the visible or audible manifestations. Treatment with botulinum toxin offers symptomatic and temporary therapeutic effects. Examples of applications in oromandibular dystonia, palatoclonus, dysphagia and laryngeal dystonia (e.g., spasmodic dysphonia) are described.

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Interessenkonflikt

Der korrespondierende Autor gibt an, dass kein Interessenkonflikt besteht. Der Koautor weist auf folgende Beziehungen hin: R. Laskawi berät die Fa. Merz. Er erhielt Drittmittel für Studien und Vortragshonorare von der Fa. Merz und Fa. Allergan.

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  1. Phoniatrie und Pädaudiologie, Klinik für Hals-, Nasen- und Ohrenheilkunde, Universitätsmedizin Göttingen, Robert-Koch-Str. 40, 37075, Göttingen, Deutschland

    A. Olthoff & R. Laskawi

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Correspondence to A. Olthoff.

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Olthoff, A., Laskawi, R. Zur oromandibulären, pharyngealen und laryngealen Anwendung von Botulinumtoxin. HNO 60, 475–478 (2012). https://doi.org/10.1007/s00106-011-2477-7

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