Skip to main content
SpringerLink
Log in

Hautalterungsexposom

Skin aging exposome

  • Leitthema
  • Published:
Die Dermatologie Aims and scope Submit manuscript

Zusammenfassung

Die Haut ist ein Barriereorgan und damit von Geburt an Umwelteinflüssen ausgesetzt, die wesentlich den Hautalterungsprozess bestimmen. Um diesen komplexen Prozess exakt beschreiben und verstehen zu können, haben wir vor einigen Jahren erstmals das Konzept des „Exposoms“ auf den umweltgetriebenen Hautalterungsprozess angewendet. In der hier vorliegenden Übersichtsarbeit fassen wir den aktuellen Kenntnisstand zum Hautalterungsexposom zusammen. Dabei gehen wir neben einer Charakterisierung der wichtigsten exposomalen Faktoren auch auf ihre relative Bedeutung für die Hautalterung und die Relevanz ihrer wechselseitigen Interaktionen ein. Abschließend diskutieren wir die sich aus diesem Konzept ergebenden klinischen Konsequenzen für eine wirksame Prävention der Hautalterung.

Abstract

The skin is a barrier organ and thus exposed to environmental factors from birth, which essentially determine skin aging. In order to describe and understand this complex process exactly, we applied the concept of the “exposome” to the environmentally induced skin aging process. In this review, we summarize current knowledge on the skin aging exposome. In this context, we characterize the most important exposomal factors, address their relative importance for skin aging and also the relevance of their mutual interactions. Finally, we discuss the clinical consequences resulting from this concept for an effective prevention of skin aging.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Abb. 1

Literatur

  1. Boukari F, Jourdan E, Fontas E et al (2015) Prevention of melasma relapses with sunscreen combining protection against UV and short wavelengths of visible light: a prospective randomized comparative trial. J Am Acad Dermatol 72:189–190

    Article  CAS  PubMed  Google Scholar 

  2. Calles C, Schneider M, Macaluso F et al (2010) Infrared A radiation influences the skin fibroblast transcriptome: mechanisms and consequences. J Invest Dermatol 130:1524–1536

    Article  CAS  PubMed  Google Scholar 

  3. Cho S, Lee MJ, Kim MS et al (2008) Infrared plus visible light and heat from natural sunlight participate in the expression of MMPs and type I procollagen as well as infiltration of inflammatory cell in human skin in vivo. J Dermatol Sci 50:123–133

    Article  CAS  PubMed  Google Scholar 

  4. Ding A, Yang Y, Zhao Z et al (2017) Indoor PM2.5 exposure affects skin aging manifestation in a Chinese population. Sci Rep 7:15329

    Article  PubMed  PubMed Central  Google Scholar 

  5. Flament F, Bazin R, Qiu H et al (2015) Solar exposure(s) and facial clinical signs of aging in Chinese women: impacts upon age perception. Clin Cosmet Investig Dermatol 8:75–84

    Article  PubMed  PubMed Central  Google Scholar 

  6. Flament F, Bourokba N, Nouveau S et al (2018) A severe chronic outdoor urban pollution alters some facial aging signs in Chinese women. A tale of two cities. Int J Cosmet Sci 40:467–481

    Article  CAS  PubMed  Google Scholar 

  7. Fuks KB, Hüls A, Sugiri D et al (2019) Tropospheric ozone and skin aging: results from two German cohort studies. Environ Int 124:139–144

    Article  CAS  PubMed  Google Scholar 

  8. Grether-Beck S, Felsner I, Brenden H et al (2021) Air pollution-induced tanning of human skin. Br J Dermatol 185:1026–1034

    Article  CAS  PubMed  Google Scholar 

  9. Grether-Beck S, Marini A, Jaenicke T et al (2014) Photoprotection of human skin beyond ultraviolet radiation. Photodermatol Photoimmunol Photomed 30:167–174

    Article  PubMed  Google Scholar 

  10. Hudson L, Rashdan E, Bonn CA et al (2020) Individual and combined effects of the infrared, visible, and ultraviolet light components of solar radiation on damage biomarkers in human skin cells. Faseb J 34:3874–3883

    Article  CAS  PubMed  Google Scholar 

  11. Hüls A, Sugiri D, Fuks K et al (2019) Lentigine formation in Caucasian women—Interaction between particulate matter and solar UVR. J Invest Dermatol 139:974–976

    Article  PubMed  Google Scholar 

  12. Hüls A, Vierkötter A, Gao W et al (2016) Traffic-related air pollution contributes to development of facial lentigines: further epidemiological evidence from Caucasians and Asians. J Invest Dermatol 136:1053–1056

    Article  PubMed  Google Scholar 

  13. Iannacone MR, Hughes MC, Green AC (2014) Effects of sunscreen on skin cancer and photoaging. Photodermatol Photoimmunol Photomed 30:55–61

    Article  PubMed  Google Scholar 

  14. Kim HH, Lee MJ, Lee SR et al (2005) Augmentation of UV-induced skin wrinkling by infrared irradiation in hairless mice. Mech Ageing Dev 126:1170–1177

    Article  CAS  PubMed  Google Scholar 

  15. Kligman LH (1996) The hairless mouse model for photoaging. Clin Dermatol 14:183–195

    Article  CAS  PubMed  Google Scholar 

  16. Kligman LH, Kligman AM (1986) The nature of photoaging: its prevention and repair. Photodermatol 3:215–227

    CAS  PubMed  Google Scholar 

  17. Krutmann J, Bouloc A, Sore G et al (2017) The skin aging exposome. J Dermatol Sci 85:152–161

    Article  PubMed  Google Scholar 

  18. Krutmann J, Gilchrest BA (2006) Photoaging of skin. In: Gilchrest BA, Krutmann J (Hrsg) Skin Aging. Springer, Heidelberg, New York, S 33–43

    Chapter  Google Scholar 

  19. Krutmann J, Schikowski T, Morita A et al (2021) Environmentally-induced (extrinsic) skin aging: exposomal factors and underlying mechanisms. J Invest Dermatol 141:1096–1103

    Article  CAS  PubMed  Google Scholar 

  20. Krutmann J, Sondenheimer K, Grether-Beck S et al (2018) Combined, simultaneous exposure to radiation within and beyond the UV spectrum: a novel approach to better understand skin damage by natural sunlight. In: Krutmann J, Merk HF (Hrsg) Environment and skin. Springer, Cham, S 11–16

    Chapter  Google Scholar 

  21. Lefebvre MA, Pham DM, Boussouira B et al (2015) Evaluation of the impact of urban pollution on the quality of skin: a multicentre study in Mexico. Int J Cosmet Sci 37:329–338

    Article  CAS  PubMed  Google Scholar 

  22. Liebel F, Kaur S, Ruvolo E et al (2012) Irradiation of skin with visible light induces reactive oxygen species and matrix-degrading enzymes. J Invest Dermatol 132:1901–1907

    Article  CAS  PubMed  Google Scholar 

  23. Ge G, Wang Y, Xu Y et al (2023) Induced skin aging by blue-light irradiation in human skin fibroblasts via TGF‑β, JNK and EGFR pathways. J Dermatol Sci. https://doi.org/10.1016/j.jdermsci.2023.06.007

    Article  PubMed  Google Scholar 

  24. Parrado C, Mercado-Saenz S, Perez-Davo A et al (2019) Environmental stressors on skin aging. Mechanistic insights. Front Pharmacol 10:759

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Passeron T (2019) The key question of irradiance when it comes to the effects of visible light in the skin. J Dermatol Sci 93:69–70

    Article  PubMed  Google Scholar 

  26. Passeron T, Picardo M (2018) Melasma, a photoaging disorder. Pigment Cell Melanoma Res 31:461–465

    Article  PubMed  Google Scholar 

  27. Peng F, Xue CH, Hwang SK et al (2017) Exposure to fine particulate matter associated with senile lentigo in Chinese women: a cross-sectional study. J Eur Acad Dermatol Venereol 31:355–360

    Article  CAS  PubMed  Google Scholar 

  28. Scharffetter-Kochanek K, Brenneisen P, Wenk J et al (2000) Photoaging of the skin from phenotype to mechanisms. Exp Gerontol 35:307–316

    Article  CAS  PubMed  Google Scholar 

  29. Schieke SM, Ruwiedel K, Gers-Barlag H et al (2005) Molecular crosstalk of the ultraviolet A and ultraviolet B signaling responses at the level of mitogen-activated protein kinases. J Invest Dermatol 124:857–859

    Article  CAS  PubMed  Google Scholar 

  30. Schroeder P, Lademann J, Darvin ME et al (2008) Infrared radiation-induced matrix metalloproteinase in human skin: implications for protection. J Invest Dermatol 128:2491–2497

    Article  CAS  PubMed  Google Scholar 

  31. Singh N, Grether-Beck S, Schikowski T et al (2023) 445 Higher ambient temperature contributes to extrinsic skin aging. J Invest Dermatol 143:S77

    Article  Google Scholar 

  32. Tang X, Wilson SR, Solomon KR et al (2011) Changes in air quality and tropospheric composition due to depletion of stratospheric ozone and interactions with climate. Photochem Photobiol Sci 10:280–291

    Article  CAS  PubMed  Google Scholar 

  33. Tigges J, Krutmann J, Fritsche E et al (2014) The hallmarks of fibroblast ageing. Mech Ageing Dev 138:26–44

    Article  CAS  PubMed  Google Scholar 

  34. Vierkötter A, Schikowski T, Ranft U et al (2010) Airborne particle exposure and extrinsic skin aging. J Invest Dermatol 130:2719–2726

    Article  PubMed  Google Scholar 

  35. Wigmann C, Hüls A, Krutmann J et al (2019) 228 estimation of the relative contribution of environmental and genetic factors to facial skin aging: a step towards individualized cosmetics. J Invest Dermatol 139:S39

    Article  Google Scholar 

  36. Wild CP (2005) Complementing the genome with an “exposome”: the outstanding challenge of environmental exposure measurement in molecular epidemiology. Cancer Epidemiol Biomarkers Prev 14:1847–1850

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. IUF – Leibniz-Institut für umweltmedizinische Forschung, Auf’m Hennekamp 50, 40225, Düsseldorf, Deutschland

    Jean Krutmann, Susanne Grether-Beck & Tamara Schikowski

  2. Derma Zentrum Wildeshausen, Wildeshausen, Deutschland

    Eugenia Makrantonaki

  3. Klinik für Dermatologie und Allergologie, Universitätsmedizin Ulm, Ulm, Deutschland

    Eugenia Makrantonaki

  4. Medizinische Hochschule Brandenburg Theodor Fontane, Neuruppin, Deutschland

    Eugenia Makrantonaki

Authors
  1. Jean Krutmann
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Susanne Grether-Beck
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Eugenia Makrantonaki
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Tamara Schikowski
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jean Krutmann.

Ethics declarations

Interessenkonflikt

J. Krutmann, S. Grether-Beck, E. Makrantonaki und T. Schikowski geben an, dass kein Interessenkonflikt besteht.

Für diesen Beitrag wurden von den Autor/-innen keine Studien an Menschen oder Tieren durchgeführt. Für die aufgeführten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.

Additional information

figure qr

QR-Code scannen & Beitrag online lesen

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Krutmann, J., Grether-Beck, S., Makrantonaki, E. et al. Hautalterungsexposom. Dermatologie 74, 657–662 (2023). https://doi.org/10.1007/s00105-023-05210-w

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00105-023-05210-w

Schlüsselwörter

Keywords

Search

Navigation