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Prurigo nodularis bei Dermatosen und systemischen Erkrankungen

Prurigo nodularis: its association with dermatoses and systemic disorders

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Zusammenfassung

Hintergrund

Prurigo wird bei vielen dermatologischen, aber auch systemischen und neurologischen Erkrankungen beobachtet.

Fragestellung

Welche Erkrankungen aus dem Bereich Dermatologie, innere Medizin und Neurologie sind mit einer Prurigo nodularis verknüpft?

Material und Methode

Beschreibung der verschiedenen Prurigo-assoziierten Krankheitsentitäten inklusive pathogenetischer und therapeutischer Aspekte.

Ergebnisse

Im Bereich der klassischen Hauterkrankungen wird eine Prurigo nodularis vor allem bei der atopischen Dermatitis, aber auch bei Lymphomen der Haut sowie kutanen mykobakteriellen Infektionen und bullösen Erkrankungen beobachtet. Generell tritt eine Prurigo nodularis ausschließlich in Verbindung mit chronischem Pruritus auf, oft im Zusammenhang mit fortgeschrittenen Nieren- oder Lebererkrankungen. Darüber hinaus können auch hämatologische und metabolische Krankheiten (solide Tumoren, Lymphome, Diabetes mellitus etc.) mit einer Prurigo nodularis verknüpft sein. Bezüglich der Pathophysiologie der Prurigo sind nur Teilaspekte bekannt. Die Behandlung der Prurigo nodularis ist schwierig und meist multimodal.

Schlussfolgerungen

Die Prurigo nodularis ist eine Hautmanifestation des chronischen Pruritus bei vielen verschiedenen Erkrankungen aus verschiedenen Bereichen der Medizin. Dies macht einen interdisziplinären diagnostischen und therapeutischen Ansatz erforderlich.

Abstract

Background

Prurigo is seen in various dermatological diseases, but also in systemic and neurological diseases.

Objectives

Which diseases in dermatology, internal medicine and neurology are linked to prurigo nodularis?

Material and methods

We describe the various entities that are associated with prurigo and discuss pathogenetic and therapeutic implications.

Results

In dermatology prurigo nodularis is most frequently seen in atopic dermatitis, but also in cutaneous lymphomas, mycobacterial skin infections and bullous diseases. Among systemic diseases, prurigo nodularis frequently is associated with pruritus of chronic renal or hepatic diseases. Prurigo nodularis is also seen in hematological and metabolic diseases (such as solid tumors, lymphoma, diabetes mellitus). The pathophysiology of prurigo is only partly understood. Treatment of prurigo nodularis is often challenging and a multimodal approach is advisable.

Conclusion

Prurigo nodularis is a skin manifestation of chronic pruritus caused by various diseases in dermatology, internal medicine and neurology. An interdisciplinary approach should be taken for diagnosis and therapy.

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- Einhaltung ethischer Richtlinien

Interessenkonflikt. T. Mettang, A. Vonend und Ulrike Raap geben an, dass kein Interessenkonflikt besteht. Der Beitrag enthält keine Studien an Menschen oder Tieren.

Author information

Authors and Affiliations

  1. Fachbereich Nephrologie, DKD Helios Kliniken Wiesbaden, Aukammallee 33, 65191, Wiesbaden, Deutschland

    T. Mettang

  2. Dermatologische Praxis, Mainz-Kastel, Deutschland

    A. Vonend

  3. Klinik für Dermatologie, Allergologie und Venerologie, Medizinische Hochschule Hannover, Hannover, Deutschland

    U. Raap

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  1. T. Mettang
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  2. A. Vonend
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  3. U. Raap
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Correspondence to T. Mettang.

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Mettang, T., Vonend, A. & Raap, U. Prurigo nodularis bei Dermatosen und systemischen Erkrankungen. Hautarzt 65, 697–703 (2014). https://doi.org/10.1007/s00105-014-2755-x

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