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Harnstoff plus Ceramide und Vitamine

Untersuchungen zur Verbesserung eines harnstoffhaltigen Externums durch Zusatz von Ceramiden und Vitaminen

Urea plus ceramides and vitamins

Improving the efficacy of a topical urea preparation by addition of ceramides and vitamins

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Zusammenfassung

Harnstoffhaltige Externa werden seit Längerem erfolgreich zur Verbesserung der Barrierefunktion der Haut eingesetzt. In der vorliegenden Studie sollte untersucht werden, ob die Wirksamkeit eines harnstoffhaltigen Externums durch den Zusatz von Vitaminen und Ceramiden verbessert werden kann. Hierzu wurde an 10 hautgesunden Probanden eine intraindividuelle Vergleichsuntersuchung durchgeführt. Es zeigte sich, dass nach einer 14-tägigen Applikation das Kombinationspräparat aus Harnstoff, Vitaminen und Ceramiden dem Harnstoffmonopräparat hinsichtlich einer Reduktion des transepidermalen Wasserverlustes und einer Erhöhung der Hautfeuchtigkeit signifikant überlegen war. Diese verbesserte Wirksamkeit war mit einer verstärkten transkriptionellen Expression von Keratinozytendifferenzierungsgenen in den behandelten Hautarealen assoziiert. So führte die Applikation beider Präparate zu einer vermehrten mRNS-Expression von Transglutaminase, Involucrin, Loricrin und Filaggrin, die vergleichend für die mit dem Kombinationspräparat behandelten Hautareale signifikant stärker ausfiel. Diese Untersuchung zeigt, dass die Wirksamkeit harnstoffhaltiger Externa durch die Zugabe von Ceramiden und Vitaminen gesteigert werden kann.

Abstract

Topical urea preparations containing urea have been used successfully to improve the barrier function of the skin. We investigated whether the efficacy of an urea-containing topical preparation could be improved by the addition of vitamins and ceramides. For this an intra-individual comparative study was conducted on 10 subjects with healthy skin. The application of the combination preparation containing urea, vitamins and ceramides for 2 weeks was significantly superior to the urea-only preparation in respect to reduction of transepidermal water loss and skin hydration levels. This improved efficacy was associated with a stronger up-regulation of the transcriptional expression of differentiation genes in keratinocytes in the treated skin areas. While both preparations caused an increased expression of the genes encoding transglutaminase-1, involucrin, loricrin and filaggrin, this increase was significantly greater in those skin areas treated with the combination preparation. This study indicates that the efficacy of topical preparations containing urea can be enhanced by the incorporation of ceramides and vitamins.

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Interessenkonflikt

Der korrespondierende Autor weist auf folgende Beziehung hin: Die Untersuchung wurde finanziell durch eine Förderung der Firma Apotheker Walter Bouhon GmbH, Nürnberg, unterstützt.

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Authors and Affiliations

  1. Institut für Umweltmedizinische Forschung (IUF) an der Heinrich-Heine-Universität Düsseldorf gGmbH, Auf’m Hennekamp 50, 40225, Düsseldorf, Deutschland

    S. Grether-Beck, K. Mühlberg, H. Brenden & J. Krutmann

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  1. S. Grether-Beck
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  2. K. Mühlberg
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  3. H. Brenden
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  4. J. Krutmann
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Correspondence to S. Grether-Beck.

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Gefördert durch das freie Hautforschungsinstitut.

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Grether-Beck, S., Mühlberg, K., Brenden, H. et al. Harnstoff plus Ceramide und Vitamine. Hautarzt 59, 717–723 (2008). https://doi.org/10.1007/s00105-008-1594-z

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