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Pathophysiologie der chronischen Wunde

Pathogenesis of chronic wounds

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Zusammenfassung

Chronische Wunden und ihre Therapie sind nicht nur ein wichtiges medizinisches, sondern vor allem auch ein großes gesellschaftliches Problem, denn sie führen zu einer sozialen Isolierung der Patienten, zu lang andauernder Arbeitsunfähigkeit und sie beeinträchtigen die Lebensqualität der Betroffenen nachhaltig. Um suffiziente Therapiemöglichkeiten zu entwickeln, ist das Verständnis der Wundheilungsvorgänge sowie der Faktoren, die die physiologische Wundheilung stören, eine wichtige Grundvoraussetzung. Diese Arbeit soll einen Überblick über die wichtigsten intrinsischen und extrinsischen Faktoren geben, die eine physiologische Wundheilung stören können und so zur Entwicklung einer chronischen Wunde führen. Ansatzpunkte, die sich hieraus für eine molekulare Beeinflussung der Wundheilung ergeben, werden dargestellt.

Abstract

Chronic, nonhealing wounds and their therapy are not only a medical problem but a severe economic one as well. Such wounds have a great effect on quality of life. Basic research has enhanced our understanding of the stimulation and inhibition of wound healing and provides the basis for introducing new and innovative treatment methods. This paper reviews the most relevant in- and extrinsic factors that disturb physiologic wound healing to result in chronic nonhealing wounds. In addition, molecular intervention modalities targeting various aspects of wound repair are demonstrated.

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  1. Klinik für Hand-, Plastische und Rekonstruktive Chirurgie, Schwerbrandverletztenzentrum, BG-Unfallklinik Ludwigshafen, Plastische und Handchirurgie der Universität Heidelberg, Ludwig-Guttmann-Straße 13, 67071, Ludwigshafen, Deutschland

    K. Riedel, H. Ryssel, E. Koellensperger, G. Germann & T. Kremer

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  1. K. Riedel
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  2. H. Ryssel
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  3. E. Koellensperger
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  4. G. Germann
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Correspondence to K. Riedel.

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Riedel, K., Ryssel, H., Koellensperger, E. et al. Pathophysiologie der chronischen Wunde. Chirurg 79, 526–534 (2008). https://doi.org/10.1007/s00104-008-1501-2

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