References
Howe FA, Opstad KS. 1H MR spectroscopy of brain tumours and masses. NMR Biomed. 2003;16(3):123–31.
Galanaud D, Nicoli F, Chinot O, Confort-Gouny S, Figarella-Branger D, Roche P, et al. Noninvasive diagnostic assessment of brain tumours using combined in vivo MR imaging and spectroscopy. Magn Reson Med. 2006;55(6):1236–45.
Law M. MR spectroscopy of brain tumours. Top Magn Reson Imaging. 2004;15(5):291–313.
Ishimaru H, Morikawa M, Iwanaga S, Kaminogo M, Ochi M, Hayashi K. Differentiation between high-grade glioma and metastatic brain tumour using single-voxel proton MR spectroscopy. Eur Radiol. 2001;11(9):1784–91.
Arvind C, Korath MP, Raveendranadhan K, Jagadeesan K. A retropective study of 1247 cases of intracranial tuberculomata diagnosed by computerised tomography. J Assoc Physicians India. 1993;41:559–61.
Mayers RB, Fredenburgh JL, Grizzle WE. Carbohydrates. In: Bancroft JD, Gamble M, editors. Theory and practice of histological techniques. 6th edition. Elsevier; 2008. pp. 166–9.
Barker PB. N-acetyl aspartate—a neuronal marker? Ann Neurol. 2001;49(4):423–4.
Urenjak J, Williams SR, Gadian D, Mark G. Noble. Specific expression of N-acetylaspartate in neurons, oligodendrocyte-type-2 astrocyte progenitors, and immature oligodendrocytes in vitro. J Neurochem. 1992;59(1):55–61.
Govindaraju V, Young K, Maudsley AA. Proton NMR chemical shifts and coupling constants for brain metabolites. NMR Biomed. 2000;13(3):129–53.
Baslow MH. Brain N-acetylaspartate as a molecular water pump and its role in the etiology of Canavan disease: a mechanistic explanation. J Mol Neurosci. 2003;21(3):185–90.
Burlina AP, Ferrari V, Facci L, Skaper SD, Burlina AB. Mast cells contain large quantities of secretagogue-sensitive N-acetylaspartate. J Neurochem. 1997;69:1314–7.
Kolwijck E, Engelke UF, van der Graaf M, Heerschap A, Blom HJ, Hadfoune M, et al. N-acetyl resonances in in vivo and in vitro NMR spectroscopy of cystic ovarian tumours. NMR Biomed. 2009;22:1093–9.
Ben Sellem D, Elbayed K, Neuville A, Moussallieh FM, Lang-Averous G, Piotto M, et al. Metabolomic characterization of ovarian epithelial carcinomas by HRMAS-NMR spectroscopy. J Oncol. 2011;2011:174019. Epub 2011 Apr 26.
Baslow MH, Shoji Y. Identification of N-acetylaspartate in the lens of the vertebrate Eye: a new model for the investigation of the function of N-acetylated amino acids in vertebrates. Exp Eye Res. 1997;64(2):283–6.
Keevil SF. Spatial localization in nuclear magnetic resonance spectroscopy. Phys Med Biol. 2006;51:R579–R636.
Andre E, Xu M, Yang D, Siow JK, Yeo TT, Xu Y, et al. Spectroscopy in sinus mucocele: N-acetyl mimickers of N-acetylaspartate. AJNR. 2006;27:2210–3.
Periakaruppan A, Kesavadas C, Radhakrishnan VV, Thomas B, Rao RM. Unique MR spectroscopic finding in colloid-like cyst. Neuroradiology. 2008;50:137–44.
Liu X, Germin BI, Ekholm S, Zhong J, Ekholm S. N-acetyl peak in MR spectra of the intracranial metastatic mucinous adenocarcinomas. Magn Reson Imaging. 2010;28(9):1390–4.
Björkman-Burtscher IM, Englund E, Skagerberg G. Proton MRS resonance at 2.05 ppm in mucin producing adenocarcinoma metastases in the brain. ISMRM. 2004;2080:394. Proceedings, 2004 (Abstract).
Opstad KS, Griffiths JR, Bell BA, Howe FA. Apparent T(2) relaxation times of lipid and macromolecules: a study of high-grade tumour spectra. J Magn Reson Imaging. 2008;27:178–84.
Hascalik S, Celik O, Sarac K, Alkan A, Mizrak B. Clinical significance of N-acetyl-L-aspartate resonance in ovarian mucinous cystadenoma. Int J Gynecol Cancer. 2006;16:423–6.
Fong MY, McDunn J, Kakar SS. Identification of metabolites in the normal ovary and their transformation in primary and metastatic ovarian cancer. PLoS One. 2011;6(5):e19963.
Kannath S, Santhosh K, Thomas B, Varma L, Sandhyamany S, Kesavadas C, Appukuttan PS, Radhakrishnan VV. Metabolite signature of developmental foregut cyst on in vivo and in vitro (1)H MR spectroscopy. J Magn Reson Imaging. 2008;28(2):493–6.
Guruprasad AS, Chandrashekar HS, Jayakumar PN, Srikanth SG, Shankar SK. Intracranial metastatic mucinous adenocarcinoma with characteristic features on diffusion-weighted imaging and in vivo magnetic resonance spectroscopy. Australas Radiol. 2004;48:129–32.
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Abdul Aziz, Z., Jethwani, D., G., A. et al. N-Acetyl peak in proton MR spectroscopy of metastatic mucinous adenocarcinoma of brain. Clin Neuroradiol 23, 153–156 (2013). https://doi.org/10.1007/s00062-012-0137-2
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DOI: https://doi.org/10.1007/s00062-012-0137-2