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Changing Directions in Acute Stroke Diagnostics

Good-Bye “Mismatch”?

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References

  1. Heiss WD, Rosner G. Functional recovery of cortical neurons as related to degree and duration of ischemia. Ann Neurol 1983;14:294–301.

    Article  PubMed  CAS  Google Scholar 

  2. Jones TH, Morawetz RB, Crowell RM, Marcoux FW, FitzGibbon SJ, DeGirolami U, Ojemann RG. Thresholds of focal cerebral ischemia in awake monkeys. J Neurosurg 1981;54:773–82.

    Article  PubMed  CAS  Google Scholar 

  3. Astrup J, Siesjö BK, Symon L. Thresholds in cerebral ischemia – the ischemic penumbra. Stroke 1981;12:723–5.

    PubMed  CAS  Google Scholar 

  4. Jansen O, Schellinger P, Fiebach J, Hacke W, Sartor K. Early recanalisation in acute ischaemic stroke saves tissue at risk defined by MRI. Lancet 1999;353:2036–7.

    Article  PubMed  CAS  Google Scholar 

  5. Davis SM, Donnan GA, Parsons MW, Levi C, Butcher KS, Peeters A, Barber PA, Bladin C, De Silva DA, Byrnes G, Chalk JB, Fink JN, Kimber TE, Schultz D, Hand PJ, Frayne J, Hankey G, Muir K, Gerraty R, Tress BM, Desmond PM, EPITHET Investigators. Effects of alteplase beyond 3 h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET): a placebo-controlled randomised trial. Lancet Neurol 2008;7:299–309.

    Article  PubMed  Google Scholar 

  6. Schellinger PD. EPITHET: failed chance or new hope? Lancet Neurol 2008;7:286–7.

    Article  PubMed  Google Scholar 

  7. Kane I, Carpenter T, Chappell F, Rivers C, Armitage P, Sandercock P, Wardlaw J. Comparison of 10 different magnetic resonance perfusion imaging processing methods in acute ischemic stroke: effect on lesion size, proportion of patients with diffusion/perfusion mismatch, clinical scores, and radiologic outcomes. Stroke 2007;38:3158–64.

    Article  PubMed  Google Scholar 

  8. Fiehler J, Kucinski T, Knudsen K, Rosenkranz M, Thomalla G, Weiller C, Röther J, Zeumer H. Are there time-dependent differences in diffusion and perfusion within the first 6 hours after stroke onset? Stroke 2004;35:2099–104.

    Article  PubMed  Google Scholar 

  9. Hossmann KA, Schuier FJ. Experimental brain infarcts in cats. I. Pathophysiological observations. Stroke 1980;11:583–92.

    PubMed  CAS  Google Scholar 

  10. Lin W, Lee JM, Lee YZ, Vo KD, Pilgram T, Hsu CY. Temporal relationship between apparent diffusion coefficient and absolute measurements of cerebral blood flow in acute stroke patients. Stroke 2003;34:64–70.

    Article  PubMed  Google Scholar 

  11. Wang Y, Hu W, Perez-Trepichio AD, Ng TC, Furlan AJ, Majors AW, Jones SC. Brain tissue sodium is a ticking clock telling time after arterial occlusion in rat focal cerebral ischemia. Stroke 2000;31:1386–91.

    PubMed  CAS  Google Scholar 

  12. Muir KW, Baird-Gunning J, Walker L, Baird T, McCormick M, Coutts SB. Can the ischemic penumbra be identified on noncontrast CT of acute stroke? Stroke 2007;38:2485–90.

    Article  PubMed  Google Scholar 

  13. Simard JM, Kent TA, Chen M, Tarasov KV, Gerzanich V. Brain oedema in focal ischaemia: molecular pathophysiology and theoretical implications. Lancet Neurol 2007;6:258–68.

    Article  PubMed  CAS  Google Scholar 

  14. von Kummer R, Bourquain H, Bastianello S, Bozzao L, Manelfe C, Meier D, Hacke W. Early prediction of irreversible brain damage after ischemic stroke at CT. Radiology 2001;219:95–100.

    PubMed  CAS  Google Scholar 

  15. Darby DG, Barber PA, Gerraty RP, Desmond PM, Yang Q, Parsons M, Li T, Tress BM, Davis SM. Pathophysiological topography of acute ischemia by combined diffusion-weighted and perfusion MRI. Stroke 1999;30:2043–52.

    PubMed  CAS  Google Scholar 

  16. Copen WA, Rezai Gharai L, Barak ER, Schwamm LH, Wu O, Kamalian S, Gonzalez RG, Schaefer PW. Existence of the diffusion-perfusion mismatch within 24 hours after onset of acute stroke: dependence on proximal arterial occlusion. Radiology 2009;250:878–86.

    Article  PubMed  Google Scholar 

  17. Jovin TG, Yonas H, Gebel JM, Kanal E, Chang YF, Grahovac SZ, Goldstein S, Wechsler LR. The cortical ischemic core and not the consistently present penumbra is a determinant of clinical outcome in acute middle cerebral artery occlusion. Stroke 2003;34:2426–33.

    Article  PubMed  Google Scholar 

  18. Barber PA, Demchuk AM, Zhang J, Buchan AM. Validity and reliability of a quantitative computed tomography score in predicting outcome of hyperacute stroke before thrombolytic therapy. ASPECTS Study Group. Alberta Stroke Programme Early CT Score. Lancet 2000;355:1670–4.

    Article  PubMed  CAS  Google Scholar 

  19. Hill MD, Rowley HA, Adler F, Eliasziw M, Furlan A, Higashida RT, Wechsler LR, Roberts HC, Dillon WP, Fischbein NJ, Firszt CM, Schulz GA, Buchan AM, PROACT-II Investigators. Selection of acute ischemic stroke patients for intra-arterial thrombolysis with pro-urokinase by using ASPECTS. Stroke 2003;34:1925–31.

    Article  PubMed  Google Scholar 

  20. von Kummer R, Allen KL, Holle R, Bozzao L, Bastianello S, Manelfe C, Bluhmki E, Ringleb P, Meier DH, Hacke W. Acute stroke: usefulness of early CT findings before thrombolytic therapy. Radiology 1997;205:327–33.

    PubMed  CAS  Google Scholar 

  21. Albers GW, Thijs VN, Wechsler L, Kemp S, Schlaug G, Skalabrin E, Bammer R, Kakuda W, Lansberg MG, Shuaib A, Coplin W, Hamilton S, Moseley M, Marks MP, DEFUSE Investigators. Magnetic resonance imaging profiles predict clinical response to early reperfusion: the Diffusion and Perfusion Imaging Evaluation for Understanding Stroke Evolution (DEFUSE) study. Ann Neurol 2006;60:508–17.

    Article  PubMed  Google Scholar 

  22. Hacke W, Furlan AJ, Al-Rawi Y, Davalos A, Fiebach JB, Gruber F, Kaste M, Lipka LJ, Pedraza S, Ringleb PA, Rowley HA, Schneider D, Schwamm LH, Leal JS, Söhngen M, Teal PA, Wilhelm-Ogunbiyi K, Wintermark M, Warach S. Intravenous desmoteplase in patients with acute ischaemic stroke selected by MRI perfusion-diffusion weighted imaging or perfusion CT (DIAS-2): a prospective, randomised, double-blind, placebo-controlled study. Lancet Neurol 2009;8:141–50.

    Article  PubMed  CAS  Google Scholar 

  23. von Kummer R. Why is the treatment with intravenous rtPA ineffective in the majority of acute ischemic stroke patients? Clin Neuroradiol 2009;19:3–5.

    Google Scholar 

  24. Smith WS, Sung G, Saver J, Budzik R, Duckwiler G, Liebeskind DS, Lutsep HL, Rymer MM, Higashida RT, Starkman S, Gobin YP, for the Multi MERCI Investigators. Mechanical thrombectomy for acute ischemic stroke: final results of the Multi MERCI trial. Stroke 2008;39:1205–12.

    Article  PubMed  Google Scholar 

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  1. Dresden, Germany

    Rüdiger von Kummer

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  1. Rüdiger von Kummer
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von Kummer, R. Changing Directions in Acute Stroke Diagnostics. Clin Neuroradiol 19, 105–107 (2009). https://doi.org/10.1007/s00062-009-1002-9

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  • DOI: https://doi.org/10.1007/s00062-009-1002-9

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