Abstract
As an essential trace mineral in mammals and the second most abundant metal in the Earth’s crust, iron acts as a double-edged sword in humans. Iron plays important beneficial roles in numerous biological processes ranging from deoxyribonucleic acid biosynthesis and protein function to cell cycle progression. However, iron metabolism disruption leads to widespread tissue degeneration and organ dysfunction. An increasing number of studies have focused on iron regulation pathways and have explored the relationship between iron and cardiovascular diseases. Ferroptosis, an iron-dependent form of programmed cell death, was first described in cancer cells and has recently been linked to heart diseases, including cardiac ischemia–reperfusion injury and doxorubicin-induced myocardiopathy. Here, we summarize recent advances in our understanding of iron homeostasis and heart diseases and discuss potential relationships between ferroptosis and cardiac ischemia–reperfusion injury and cardiomyopathy.
Zusammenfassung
Als essenzielles Spurenelement bei Säugetieren und als zweithäufigstes Metall in der Erdkruste ist Eisen ein zweischneidiges Schwert für den Menschen. Eisen spielt eine wichtige nützliche Rolle in zahlreichen biologischen Prozessen von der Biosynthese der Desoxyribonukleinsäure und der Proteinfunktion bis zum Ablauf des Zellzyklus. Jedoch führt eine Störung des Eisenstoffwechsels zu einer ausgedehnten Gewebedegeneration und Organfunktionsstörungen. Eine zunehmende Zahl von Studien hat die Signalwege der Eisenregulation in den Fokus genommen und den Zusammenhang zwischen Eisen und Herz-Kreislauf-Erkrankungen untersucht. Ferroptose, eine eisenabhängige Form des programmierten Zelltods, wurde zuerst bei Krebszellen beschrieben und ist erst kürzlich mit Herzkrankheiten, einschließlich des kardialen Ischämie-Reperfusions-Schadens und der durch Doxorubicin induzierten Myokardiopathie, in Verbindung gebracht. Im vorliegenden Beitrag werden die aktuellen Fortschritte im Verständnis von Eisenhomöostase und Herzerkrankungen zusammengefasst sowie mögliche Zusammenhänge zwischen Ferroptose und kardialem Ischämie-Reperfusions-Schaden sowie Kardiomyopathie erörtert.
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This work was supported by Natural Science Foundation of Zhejiang Province, Grant No: LY16H020008
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H. Ying, Z. Shen, J. Wang and B. Zhou declare that they have no competing interests.
For this article no studies with human participants or animals were performed by any of the authors. All studies performed were in accordance with the ethical standards indicated in each case.
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Ying, H., Shen, Z., Wang, J. et al. Role of iron homeostasis in the heart. Herz 47, 141–149 (2022). https://doi.org/10.1007/s00059-021-05039-w
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DOI: https://doi.org/10.1007/s00059-021-05039-w