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Synthesis, characterization and biological evaluation of some novel fluoroquinolones

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Abstract

Different derivatives of fluoroquinolones were synthesized by combining it with different thiadiazoles. The synthesized compounds were characterized by infrared spectroscopy, proton nuclear magnetic resonance and mass spectral data. The compounds were screened for their antibacterial and antifungal activity. Ciprofloxacin derivatives with thiadiazoles 7c showed good antibacterial as well as antifungal activities, whereas 13c and 13e showed antibacterial and antifungal activity respectively. Sparfloxacin derivative 8c showed both antibacterial and antifungal activity. Sparfloxacin derivatives 14b and 14e showed antibacterial and antifungal activity respectively.

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Authors and Affiliations

  1. Institute of Pharmaceutical Research, GLA University, NH # 2, Delhi-Mathura Road, Post: Chaumuhan, Mathura, U.P., 281406, India

    Neelanjana Pandit, Kamal Shah, Neetu Agrawal & Pradeep Mishra

  2. School of Pharmacy and Research, Peoples University, Bhopal, M.P., 462037, India

    Neeraj Upmanyu

  3. Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi, U.P., 221005, India

    Sushant K. Shrivastava

Authors
  1. Neelanjana Pandit
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  2. Kamal Shah
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  3. Neetu Agrawal
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  4. Neeraj Upmanyu
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  5. Sushant K. Shrivastava
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  6. Pradeep Mishra
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Correspondence to Kamal Shah.

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Pandit, N., Shah, K., Agrawal, N. et al. Synthesis, characterization and biological evaluation of some novel fluoroquinolones. Med Chem Res 25, 843–851 (2016). https://doi.org/10.1007/s00044-016-1526-x

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  • DOI: https://doi.org/10.1007/s00044-016-1526-x

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