Abstract
A series of novel hybrid 4-aminoquinoline-1,3,5-triazine derivatives were developed and subsequently tested against representative Gram-positive and Gram-negative microorganisms for determination of their antibacterial activity. Screening results indicate that, title molecule exhibit moderate to potent activity in comparison to standard. These hybrid derivatives were synthesized through a facile synthetic routes and structure of reaction intermediates as well as target molecules were recognised with the aid of various spectroscopic techniques viz., FTIR, NMR, mass and elemental analysis.
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Acknowledgments
Authors are gratified to SAIF, Central Drug Research Institute, Lucknow, India for providing spectral data of compounds synthesized herein and SHIATS for providing basic facilities to carry out the project.
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Bhat, H.R., Pandey, P.K., Ghosh, S.K. et al. Development of 4-aminoquinoline-1,3,5-triazine conjugates as potent antibacterial agent through facile synthetic route. Med Chem Res 22, 5056–5065 (2013). https://doi.org/10.1007/s00044-013-0521-8
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DOI: https://doi.org/10.1007/s00044-013-0521-8