Abstract
In this article, we report herein the SAR studies of a series of (1H-indol-3-yl)alkyl-3-(1H-indol-3-yl)propanamide 10(a–j), 11(a–j). The synthesized compounds were evaluated for their preliminary in vitro antibacterial, antifungal activity and were screened for antitubercular activity against Mycobacterium tuberculosis H37Rv strain. The synthesized compounds displayed interesting antimicrobial activity.
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Acknowledgments
Authors are thankful to Head of the Department of Biochemistry, Justice K. S. Hegde Medical Academy, to carry out biological studies. They are also grateful to the Head, Chemistry Department and School of Chemical Sciences for providing necessary laboratory facilities for the research work and valuable support.
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Karuvalam, R.P., Pakkath, R., Haridas, K.R. et al. Synthesis, characterization, and SAR studies of new (1H-indol-3-yl)alkyl-3-(1H-indol-3-yl)propanamide derivatives as possible antimicrobial and antitubercular agents. Med Chem Res 22, 4437–4454 (2013). https://doi.org/10.1007/s00044-012-0451-x
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DOI: https://doi.org/10.1007/s00044-012-0451-x