Abstract
Efficient syntheses of a series of novel bisquinolines have been accomplished from 8-hydroxy quinolines under phase transfer catalyzed conditions using tetrabutylamoniumbromide as phase transfer catalyst. In vitro antibacterial and antifungal study of the synthesized analogues revealed six of them to show significant antibacterial and four to show significant antifungal activity. Among them 3c and 6c show most significant antibacterial activities with minimum inhibitory concentration value 32 μg/mL against four bacterial strains. Ultra structural studies of the microbes treated with 6c demonstrated deformation of cell wall and cell agglomeration. The bisquinolines exhibiting bacteriostatic or fungistatic activity may be developed as newer antimicrobial agents.
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Acknowledgments
The authors express their gratitude to the Director, IICB for laboratory facilities, the Council of Scientific and Industrial Research (CSIR) for providing the funding and fellowships to K. B. S., A. M., S. M., R. P., P. S., S. N. and A. H. We are indebted to Dr. B. Achari, Emeritus Scientist, CSIR, for his valuable suggestions.
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Sahu, K.B., Ghosh, S., Banerjee, M. et al. Synthesis and in vitro study of antibacterial, antifungal activities of some novel bisquinolines. Med Chem Res 22, 94–104 (2013). https://doi.org/10.1007/s00044-012-0011-4
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DOI: https://doi.org/10.1007/s00044-012-0011-4